This practical, well-organized reference delves deeply into functional group transformations, to provide all the detailed information that researchers need. - Topics are organized into the following sections: oxidation, reduction, asymmetric synthesis, and functional group manipulations
- Each section includes a description of the functional group transformation, the historical perspective, mechanisms, variations and improvements on the reaction, synthetic utilities and applications for the reaction, experimental details, and references to the primary literature
- Contributors are well-known and respected for their work on the specific name reactions.
Table of Contents:
Foreword vii Preface viii
Contributing Authors ix
Chapter 1. Asymmetric Synthesis 1
Chapter 2. Reduction 85
Chapter 3. Oxidation 159
Chapter 4. Olefination 333
Chapter 5. Amine Synthesis 423
Chapter 6. Carboxylic Acid Derivatives Synthesis 457
Chapter 7. Miscellaneous Functional Group Manipulations 551
Appendixes 697
Appendix 1. Table of Contents for Volume 1: Name Reactions in Heterocyclic Chemistry 697
Appendix 2. Table of Contents for Volume 3: Name Reactions for Chain Extension 700
Appendix 3. Table of Contents for Volume 4: Name Reactions for Ring Formation 703
Appendix 4. Table of Contents for Volume 5: Name Reactions in Heterocyclic Chemistry-2 705
Subject Index 709
About the Author :
Jie Jack Li is a medicinal chemist at Pfizer Global Research and Development in Ann Arbor, Michigan. He is coauthor of Contemporary Drug Synthesis and editor of Name Reactions in Heterocyclic Chemistry (both from Wiley). E. J. Corey, Professor Emeritus at Harvard University, is scientific editorial advisor for this book. Dr. Corey won the Nobel Prize in Chemistry in 1990 for his development of the theory and methodology of organic synthesis, and was awarded the Priestley Medal in 2004.
Review :
"Unlike many previous books on name reactions, which present many reactions but treat them superficially, this book provides an excellent selection of useful name reactions, which have been given in depth, well-illustrated, instructional, and well-referenced accounts." (Journal of Medicinal Chemistry, February 2008) "Helps you explore how you think, communicate and react, allowing you to change your behaviours and become a more expert professional practitioner." (Journal of Perioperative Practice, April 2008)
"Reading this book has been enjoyable experience. Again and again, one comes across surprising reaction possibilities of well-known reagents, or some lesser known variants of common transformations." (Angewandte Chemie)
"This book provides an excellent selection of useful name reactions, which have been given in depth, well-illustrated, instructional, and well-referenced accounts." (Journal of Medicinal Chemistry, January 11, 2008)
