Multipoint Mapping and Linkage Based Upon Affected Pedigree Members: Genetic Analysis Workshop(Vol 329 Progress in Clinical & Biological Research)

Using both empirical and simulated data, this study examines selected computational approaches and algorithms for analyzing the genetic etiology of a disease. It compares a wide variety of analytical methods and highlights areas of substantive interest to geneticists investigating human disease. Its methodologic emphasis provides useful guidance for the design of future studies to map disease susceptibility loci. In the first section, a group of experts investigate a multipoint mapping problem by analyzing data that encompass chromosome marker 7 information on cystic fibrosis families. Existing methodologies and computer programs for multipoint mapping are compared and contrasted under the constraints imposed by real human data. In assessing alternative approaches to complex mapping problems, theoretical as well as empirical contributions are considered. The remainder of the volume examines simulated data that comprise two distinct problem sets in which disease and marker loci both are segregating. Here, experts compare methods of linkage analysis that rely only upon data collected on affected individuals.

Table of Contents:
Partial table of contents:; MULTIPOINT LINKAGE ANALYSIS; Genetic Analysis Workshop 6: Multipoint Mapping of Loci in the Region of Cystic Fibrosis (M. Spence, et al.); Multipoint Analysis by Simplifying General Expressions of Likelihood (J. Clayton & M.- P. Roth); A Simple Scheme for Preliminary Ordering of Multiple Loci: Application to 45 CF Families (C. Falk); Linkage Map of Anonymous Loci Near the CF Gene (J. Haines, et al.); Pairwise Permutation Algorithm for Ordering Loci (S. Hazout, et al.); Preliminary Ordering of Multipoint Linkage Data (M. Knapp, et al.); Multipoint Linkage Analysis of the Cystic Fibrosis Region (E. Lander & M. Daly); LINKAGE ANALYSIS OF AFFECTED PEDIGREE MEMBERS; Genetic Analysis Workshop 6: Linkage Analysis Based on Affected Pedigree Members (R. Elston, et al.); A Linkage Test with Identity-by-Descent Marker Data from Pairs of Affected Relatives (R. Cantor); Analysis of Affected Sib Pairs Using Information from Extended Families (L. Sandkuyl); Comparison of the Affected-Pedigree-Member and Lod-Score Methods (A. Goldstein, et al.); Linkage Analysis for a Disease with a Complex Mode of Inheritance in a Simulated Data Set (T. Lehner, et al.); Index.