Ageing Vulnerability
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Home > Medicine & Health Science textbooks > Medical specialties, branches of medicine > Geriatric medicine > Ageing Vulnerability: Causes and Interventions(Novartis Foundation Symposia)
Ageing Vulnerability: Causes and Interventions(Novartis Foundation Symposia)

Ageing Vulnerability: Causes and Interventions(Novartis Foundation Symposia)


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About the Book

With the ever-increasing rise in life expectancy, there is an urgent need to improve our understanding of the relationship between ageing and the pathogenesis of age-related diseases in order to identify more effective means of prevention, amelioration and management of such diseases. In addition, there is a need to reduce the social and economic impact of the ageing population. Age-related morbidity and mortality vary dramatically among individuals; this book focusses on individual differences in susceptibility to age-related disorders. It contains contributions from leading experts in the field on topics such as: age-related pathology in the brain, age-related processes in stem cells, and age-related effects on the immune system and in bone, muscle and cardiovascular tissue. For all those with an interest in the biology of ageing, this is compulsory reading.

Table of Contents:
Symposium on Ageing vulnerability: causes and interventions, held at the Novartis Foundation, London, 29 February^3 March 2000 Editors: Gregory Bock (Organizer) and Jamie A. Goode This symposium is based on a proposal made by Gary Andrews. It was organized as a key component and in support of the United Nations Project ‘A Research Agenda on Ageing for the 21st Century’ Thomas B. L. Kirkwood Introduction 1 Gary R. Andrews The priority of basic research on ageing vulnerability in a comprehensive research agenda on ageing for the 21st century 4 Discussion 9 Julie K. Andersen Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson’s disease? 11 Discussion 20 Ashley I. Bush and Lee E. Goldstein Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer’s disease and age-related cataracts 26 Discussion 38 General discussion I The role of glial cells in the ageing brain 44 R.N. Kalaria, C.G. Ballard, P.G. Ince, R.A. Kenny, I.G. McKeith, C.M. Morris, J.T. O’Brien, E. K. Perry, R.H. Perry and J. A. Edwardson Multiple substrates of late-onset dementia: implications for brain protection 49 Discussion 60 C. S. Potten, K. Martin and T. B. L. Kirkwood Ageing of murine small intestinal stem cells 66 Discussion 79 Amiela Globerson Haematopoietic stem cell ageing 85 Discussion 96 General discussion II 101 James K. Leung and Olivia M. Pereira-Smith Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing 105 Discussion 110 Jerry W. Shay and Woodring E.Wright Ageing and cancer: the telomere and telomerase connection 116 Discussion 125 Rita B. E¡ros Ageing and the immune system 130 Discussion 139 General discussion III 146 Lis Mosekilde Mechanisms of age-related bone loss 150 Discussion 166 Edward G. Lakatta, Steven J. Sollott and Salvatore Pepe The old heart: operating on the edge 172 Discussion 196 Anthony Cerami and Peter Ulrich Pharmaceutical intervention of advanced glycation end products 202 Discussion 212 General discussion IV 217 Holly Van Remmen, Zhongmao Guo and Arlan Richardson The anti-ageing action of dietary restriction 221 Discussion 230 D. A. Cottrell, E. L. Blakely, M. A. Johnson, G.M. Borthwick, P. I. Ince and D. M. Turnbull Mitochondrial DNA mutations in disease and ageing 234 Discussion 243 Douglas C. Wallace A mitochondrial paradigm for degenerative diseases and ageing 247 Discussion 263 Final discussion 267 Index of contributors 273 Subject index 275

About the Author :
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.


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Product Details
  • ISBN-13: 9780471494386
  • Publisher: John Wiley & Sons Inc
  • Publisher Imprint: John Wiley & Sons Inc
  • Height: 238 mm
  • No of Pages: 300
  • Returnable: N
  • Spine Width: 19 mm
  • Weight: 567 gr
  • ISBN-10: 0471494380
  • Publisher Date: 19 Feb 2001
  • Binding: Hardback
  • Language: English
  • Returnable: N
  • Series Title: Novartis Foundation Symposia
  • Sub Title: Causes and Interventions
  • Width: 158 mm


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