Drug Discovery and Development, Volume 1: Drug Discovery

From first principles to real-world applications -- here is the first comprehensive guide to drug discovery and development


Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines--from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process.

The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and development--from initial conceptualization to commercialization to clinicians and medical practitioners. Volume 1: Drug Discovery describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary. Volume 2: Drug Development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing--including drug coloring and delivery methods.

Featuring contributions from a world-class team of experts, Drug Discovery and Development:
* Features fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil)
* Discusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer
* Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics

Drug Discovery and Development is an indispensable working resource for industrialchemists, biologists, biochemists, and executives who work in the pharmaceutical industry.

Table of Contents:
Contributors.

Preface.

1. From Patent to Prescription: Paving the Perilous Path to Profit (Richard J. Pariza).

2. Medicinal Chemistry in the New Millennium: A Glance into the Future (Paul W. Erhardt).

ADMET-Related Synergies, 59

3. Contemporary Drug Discovery (Lester A. Mitscher and Apurba Dutta).

4. Combinatorial Chemistry in the Drug Discovery Process (Ian Hughes).

5. Parallel Solution-Phase Synthesis (Norton P. Peet and Hwa-Ok Kim).

6. Timing of Analog Research in Medicinal Chemistry (János Fischer and Anikó Gere).

7. Possible Alternatives to High-Throughput Screening (Camille G. Wermuth).

8. Proteomics and Drug Discovery (Susan Dana Jones and Peter G. Warren).

Appendix: Public-Domain Software Tools and Databases.

9. Using Drug Metabolism Databases During Drug Design and Development (Paul W. Erhardt).

10. Discovery of the Antiulcer Drug Tagamet (C. Robin Ganellin).

11. Discovery of Potent Nonpeptide Vasopressin Receptor Antagonists (Bruce E. Maryanoff).

12. Discovery and Development of the Ultrashort-Acting Analgesic Remifentanil (Paul L. Feldman).

13. Discovery and Development of Nevirapine (Karl Grozinger, John Proudfoot, and Karl Hargrave).

14. Applications of Nuclear Imaging in Drug Discovery and Development (John W. Babich and William C. Eckelman).

15. Polymeric Sequestrants as Nonabsorbed Human Therapeutics (Pradeep K. Dhal, Chad C. Huval, and S. Randall Holmes-Farley).

16. Botanical Immunomodulators and Chemoprotectants in Cancer Therapy (Bhushan Patwardhan, Sham Diwanay, and Manish Gautam).

Index.

About the Author :
Mukund S. Chorghade, PHD, is President of Chorghade Enterprises, Inc., a firm based in Natick, Massachusetts that provides consultations to major pharmaceutical companieson collaborations with worldwide academic, government, and industrial laboratories; European technology-based companies; process reengineering; and project management of technology transfer.

Review :
"...provides a nice survey of most of the key topics facing discovery houses today." (Doody's Health Services)

"This reasonably priced book is well-written and produced. It has a useful 32-page index, and it may be considered for acquisition by individuals and libraries." (Journal of Medicinial Chemistry, October 5, 2006)