About the Book
Transgenic and knockout mutations provide an important means for understanding gene function, as well as for developing therapies for genetic diseases. This engaging and informative book discusses the many advances in the field of transgenic technology that have enabled researchers to bring about various changes in the mouse genome. Equal emphasis is given to both the principles of transgenic and knockout methods and their applications. A clear and concise format provides researchers with a comprehensive review of the behavioral paradigms appropriate for analyzing mouse phenotypes. What's Wrong with My Mouse? explains the differences between transgenic knockout mice and their wild-type controls, while providing critical information about gene function and expression. This volume recognizes that newly identified genes can provide useful insights into brain functioning, including brain malfunctioning in disease states. Written by a world-renowned expert in the field, the material also covers: How to generate a transgenic or knockout mouse functions (open field, holeboard, rotarod, balance, grip, circadian activity, etc.)
Sensory abilities (olfaction, vision, hearing, taste, touch, nociception) Reproductive behavior, social behavior, and emotional behavior Researchers in neuroscience, pharmacology, genetics, developmental biology, and cell biology will all find this book essential reading.
Table of Contents:
Designer Mice: Scope and Sourcebooks. Of Unicorns and Chimeras: How to Generate a Transgenic or Knockout Mouse General Health: Give Your Mouse a Physical; Neurological Reflexes. Motor Functions: Open Field, Holeboard, Rotarod, Balance, Grip, Circadian Activity, Circling, Stereotypy, Ataxic Gait, Seizures. Sensory Abilities: Olfaction, Vision, Hearing, Taste, Touch, Nociception. Learning and Memory: Morris Swim Task, Spatial Mazes, Cued and Contextual Conditioning, Conditioned Taste Aversion, Conditioned Eye Blink, Olfactory Discrimination, Social Recognition, Passive Avoidance, Schedule Controlled Operant Tasks, Motor Learning. Feeding and Drinking: Daily Consumption, Restricted Access, Choice Tests, Microstructural Analysis. Reproductive Behaviors: Sexual and Parental Behaviors. Social Behaviors: Social Interaction, Nesting, Grooming, Juvenile Play, Aggression. Emotional Behaviors: Animal Models of Psychiatric Disorders: Fear, Anxiety, Depression, Schizophrenia. Reward: Self-Administration of Additive Drugs, Conditioned Place Preference. The Next Generation: Conditional and Inducible Mutations, Quantitative Trait Loci Analysis, Chemical Mutagenesis, Gene Therapy, Ethical Issues. Bibliography. Index.
Review :
"...this valuable book is currently the most complete overview of behavioral procedures available...it is a must have and a must read book..." (Genes, Brain, and Behavior, 2002)
