Architecture of Eukaryotic Genes

Twenty-eight articles by leading international researchers survey the statics and dynamics of chromatin architecture and highlight their current research in the field. The collection provides the first synopsis of all aspects of eukaryotic gene architecture and covers animal, human, and plant genes. Among the topics covered are the structure and topology of DNA, the architecture of genes in their normal and transgenic environments, the structure and role of various nuclear proteins, and chromatic architecture and chromosome topology. Extended, up-to-date bibilographies allow the reader to pursue specific topics in greater depth. The book is based on papers presented at the First International Symposium on the Chromatin Structure of Genes held in Frankfurt am Main in 1986.

Table of Contents:
DNA STRUCTURE AND GENE STRUCTURE. Structural and Topological Polymorphism of DNA (A. Nordheim, et al.). The Molecular Architecture of Plant Genes: A Phylogenetic Perspective (K. Elliston & J. Messing). Transfer, Structure and Expression of Foreign Genes in Plants (K. Weising, et al.). Enhancers and Trans-acting Factors (H. Scholer, et al.). DNA-AFFINE PROTEINS AND THEIR GENES. Histones, Histone Variants and Postsynthetic Histone Modifications (D. Doenecke). Histones and HMG Proteins of Higher Plants (S. Spiker). The Role of Histone H1 in Nucleosomes and Chromatin Fibers (F. Thoma). The HMG Proteins and Their Genes (G. Goodwin & M. Bustin). Recent Progress in the Study of Nonhistone Chromosomal Proteins (T. James, et al.). Histone Genes in Higher Plants (C. Gigot). DNA - PROTEIN INTERACTIONS. Nucleosomes and Transcription (Y. Lorch, et al.). Nucleosome Positioning in vivo and in vitro (B. Neubauer, et al.). Mechanisms of Nucleosome Positioning Tested in Minichromosomes of Yeast Saccaromyces cerevisiae (F. Thoma). CHROMATIN. Chromatin of Active and Inactive Genes (I. Cartwright & S. Elgin). Chromatin Structure of Plant Genes (G. Kahl, et al.). Chromatin Domains and Gene Expression - Different Chromatin Conformations Characterize the Various Functional States of the Chicken Lysozymer Gene (H. Fritton, et al.). Regulatory Function and Molecular Structure of DNase I- Hypersensitive Elements in the Chromatin Domain of a Gene (A. Sippel, et al.). Organization and Length Heterogeneity of Plant Ribosomal RNA Genes (V. Hemleben, et al.). Chromatin Structure and Expression of Plant Ribosomal RNA Genes (W. Thompson, et al.). Architecture of the 5'Flanking Regions of the Maize Adh Genes (A.-L. Paul, et al.). DNA METHYLATION AND TRANSCRIPTION. Eukaryotic Gene Inactivation by Sequence-specific Promoter Methylation and the Release of the Transcription Block (W. Doerfler, et al.). DNA Methylation and Its Effect on Transformed Gene Expression (A. Hepburn). Enzymology of DNA Methylation in Mammalian Cells (D. Drahovsky & G. Pfeifer). NUCLEAR MATRIX. Nuclear Matrix (D. Werner, et al.). Nuclear Scaffold and the Higher-order Folding of Eukaryotic DNA (S. Gasser). CHROMOSOMES. Three-dimensional Organization of Interphase Chromosomes in Polytene Nuclei of Drosophila melanogaster (M. Hochstrasser, et al.). Phased Approaches to Mapping the Physical Structure of Entire Chromosomes (C. Smith, et al.). PERSPECTIVES. Perspectives of Chromatin Research: Plant and Animal (J. Bonner). Index.

About the Author :
Guenter Kahl is the author of Architecture of Eukaryotic Genes, published by Wiley.