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Comparative Pharmacokinetics – Principles, Techniques and Applications 3e

Comparative Pharmacokinetics – Principles, Techniques and Applications 3e


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About the Book

Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.

Table of Contents:
Introduction; Principles of drug movement in the body; Absorption; Distribution; Renal Elimination; Hepatic biotransformation and biliary excretion; Compartmental models; Noncompartmental models; Nonlinear models; Physiological models; Dosage regimens; Simultaneous pharmacokinetics-pharmacodynamics modeling; Study design and data analysis; Population pharmacokinetics models and Bayesian forecasting applied to clinical pharmacokinetics; Dosage adjustment in renal diseases; Interspecies extrapolations; Tissue residues and withdrawal times, Index.

About the Author :
Jim E. Riviere , D.V.M., Ph.D. is the Burroughs Wellcome Fund Distinguished Professor of Veterinary Pharmacology and Director, Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, N.C. .

Review :
"This book is helpful in understanding and designing pharmacokinetic studies, illustrating basic concepts and noting the species differences. . . The book does a good job of explaining a concept and then expands with more specific examples. It provides a good base for pharmacokinetic modeling and illustrates the pitfalls with interspecies extrapolation." (Doody's, 21 October 2011)


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Product Details
  • ISBN-13: 9780470959916
  • Publisher: John Wiley and Sons Ltd
  • Publisher Imprint: Wiley-Blackwell
  • Height: 250 mm
  • No of Pages: 376
  • Weight: 666 gr
  • ISBN-10: 0470959916
  • Publisher Date: 25 Mar 2011
  • Binding: Other digital
  • Language: English
  • Spine Width: 15 mm
  • Width: 150 mm


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