Over the last few years there have been huge advances made in our understanding of the interactions between the brain and the gut – the enteric nervous system. This book is particularly relevant in the understanding, diagnosis and management of irritable bowel syndrome – the most common functional disorder of the bowel.
IBS has been diagnosed in 10-20% of adults in the US, and symptoms of IBS are responsible for more than 3 million visits to the physician in the US.
This book is aimed at specialist gastroenterologists but also should be of interest for trainees and fellows in gastroenterology, as well as PCPs and GPs with an interest in this subject.
Table of Contents:
Contributors Preface
Section A: Basic Principals
Chapter 1 Functional Neuro-anatomy
Chapter 2 Neuro-physiology
Chapter 3 Brain to Gut Signalling - Sensory mechanisms
Chapter 4 Brain to Gut Signalling - Central Processing
Section B: Mechanisms of functional GI Disorders
Chapter 5 Developmental disorders of the enteric nervous system
Chapter 6 Inflammation
Chapter 7 Stress and the Gut - Central Influences
Chapter 8 Stress and the Gut - Peripheral Effects
Section C: Patho-physiology and Treatment of Human Diseases
Chapter 9 Oesophageal disorders
Chapter 10 Gastric disorders
Chapter 11 Small Bowel Disorders
Chapter 12 Colonic disorders
Chapter 13 Anorectal Disorders
Chapter 14 Central Nervous System Injury
Chapter 15 Diarrhoea - Predominant bowel disorders following inflammation and infection
Section D: Advances in Pharmaco Therapy.
Chapter 16 Functional targets for pharmaco therapy – An overview
Chapter 17 Neuro Kininin Receptor Modulators
Chapter 18 Serotonin Receptor Modulators
Chapter 19 Emerging Transmitters
Index
About the Author :
Robin Spiller is Professor of Gastroenterology in the Wolfson Digestive Diseases Centre, University Hospital, Nottingham. He has had a long-standing interest in the pathophysiology of funtional bowel diseases particularly those arising after bouts of gastrointestinal infections.
David Grundy is Professor of Biomedical Science at the Unversity of Sheffield. He has for many years pioneered the study of afferent signalling in the gut with particular interest in the mechanisms that mediate and modulate sensory signal transduction.
