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Molecular Analysis and Genome Discovery

Molecular Analysis and Genome Discovery


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About the Book

This advanced level textbook provides a comprehensive overview of recent developments in the area of molecular based diagnostics (including nucleic acids, biosensors and immunoessays) of disease markers. It also covers the impact of techniques such as in vitro nucleic acid amplifications (e.g. PCR) and other amplification methods, as well as gene and biochip production and automated techniques such as fluorescent sequencing. The book discusses key concepts where new and merging areas, including pharmacogenomics, proteomics and functional genomics, are being researched and developed. In addition, examples are given where this new area of bioscience has or may be successfully applied.

Table of Contents:
List of Contributors 1. Pharmacogenetics and Pharmacogenomics: An Overview (W. Kalow). 2. Quantitative TaqMan Real-time PCR: Diagnostic and Scientific Applications (Jörg Dötsch, Ellen Schoof and Wolfgang Rascher). 3. Hybridization Probes for Quantitative PCR (Elaine Lyon). 4. An Overview of Genotyping and Single Nucleotide Polymorphisms (SNP) (Ivo Glynne Gut). 5. High-throughput Mutation Screening (Paal Skytt Andersen and Lars Allan Larsen). 6. Determination of Nucleic Acid Sequence by Pyrosequencing (Elaine Elahi and Mostafa Ronaghi). 7. An Introduction to DNA Chips (Magdalena Gabig-Ciminska and Andrzej Ciminski). 8. Overview of Microarrays in Genomic Analysis (Janette K Burgess). 9. Overview of Differential Gene Expression by High-throughput Analysis (Kin-Ying To). 10. Aptamers: Powerful Molecular Tools for Therapeutics and Diagnostics (Eva Baldrich i Rubio, Mònica Campàs i Homs and Ciara K. O'Sullivan). 11. Chip-based Proteomics Technology (Mikhail Soloviev, Richard Barry and Jon Terrett). 12. Infectomics Overview: Holistic and Integrative Studies of Infectious Diseases (Sheng-He Huang and Ambrose Jong). 13. The Drug Discovery Process (Roberto Solari). 14. Structure-based Drug Discovery (Chen-Chen Kan, Kevin Hambly and Derek A. Debe). 15. Protein interaction-targeted Drug Discovery (Gary Hudes, Sanjay Menon and Erica A. Golemis). 16. Overview of Quantitative Structure–activity Relationships (QSAR) (David A. Winkler). Index.

About the Author :
Ralph Rapley, Ph.D. Department of Biosciences, University of Hertfordshire, Hatfield, UK Electrical Engineers, Mechanical Engineers, Automation Engineers, Optical Industry, Students in Electrical Engineering, Students in Physics, Robotics Engineers, Automation Industry, Sensor Industry, Automobile Industry, Aircraft and Space Industry, Company Libraries, University Institutes and Libraries, Industry. Stuart Harbron is the editor of Molecular Analysis and Genome Discovery, published by Wiley.

Review :
"This is a highly recommended book for graduate students and professionals in the field of pharmacology, molecular biology and genetics." (E-STREAMS, March 2005)


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Product Details
  • ISBN-13: 9780470668269
  • Publisher: John Wiley & Sons Inc
  • Publisher Imprint: John Wiley & Sons Inc
  • Language: English
  • ISBN-10: 0470668261
  • Publisher Date: 15 Jan 2010
  • Binding: Digital (delivered electronically)
  • No of Pages: 388


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