Psoriasis: Diagnosis and Management

Practical and user-friendly, this is the ideal guide to the diagnosis and treatment of psoriasis, helping you navigate a logical management pathway through a complex maze of possibilities. Psoriasis is a cruel disease that can seriously affect the sufferer’s quality and length of life. It is also highly idiosyncratic, with features that vary greatly from patient to patient; this being mirrored in the highly variable response to treatment. It is increasingly recognized that psoriasis is not a discrete disease and that many patients suffer two or three comorbid conditions that can complicate the efforts of doctors treating patients. Psoriasis: Diagnosis and Management will provide dermatologists of all levels with a practical, well-illustrated approach to fully understanding the disease, including clear, clinical guidance to enable best-practice and effective management of patients. In full color throughout and excellently illustrated, key highlights include: easily understandable description of the psoriasis pathogenesis; a strong emphasis on the clinical features of psoriasis; careful consideration of comorbid conditions as part of the psoriatic spectrum to be managed; coverage of both traditional and contemporary management approaches; plenty of diagnostic algorithms and management protocols to aid the daily practical care of patients. Brought to you by several of the world’s leading authorities on the subject, Psoriasis: Diagnosis and Management is an essential purchase for the dermatologist.

Table of Contents:
List of contributors, vii Preface, ix Part I: Epidemiology and economic aspects 1 Epidemiology and economic aspects, 3 Luigi Naldi, Simone Cazzaniga, and Giovanna Rao 2 Cost-effective psoriasis management, 11 Luigi Naldi, Simone Cazzaniga, and Giovanna Rao Part II: Etiology and pathogenesis 3 Microscopic skin alterations, 21 Kerstin Wolk, Hans-Joachim Röwert-Huber, and Robert Sabat 4 Pathogenesis of psoriasis, 28 Robert Sabat and Kerstin Wolk 5 Genetics of psoriasis, 49 Ellen Witte and Robert Sabat Part III: Clinical features/diagnostic procedure 6 Plaque psoriasis, 57 Wolfram Sterry 7 Gutatte psoriasis, 76 Wolfram Sterry and Frank Bachmann 8 Erythrodermic psoriasis, 81 Wolfram Sterry 9 Pustular psoriasis, 84 Sandra Philipp 10 Nail psoriasis, 93 Sandra Philipp 11 Psoriatic arthritis, 98 Marina Backhaus 12 Mucosal presentation of psoriasis, 108 Georgios Kokolakis 13 Psoriasis in different life situations, 112 Sandra Philipp Part IV: Evaluation of disease severity 14 Evaluation of disease severity—clinical scores and questionnaires, 129 Frank Bachmann Part V: Psoriasis and associated diseases 15 Psoriasis and associated diseases, 143 Steven M. Nwe and Kenneth B. Gordon Part VI: Therapeutic management 16 Therapeutic aim of psoriasis therapy, 161 Sandra Philipp 17 Treatment of plaque psoriasis, 163 Topical therapy of psoriasis, 163 Knud Kragballe Phototherapy and photochemotherapy, 175 Erhard Hölzle Classical systemic treatments, 184 Peter C.M. van de Kerkhof Biologics, 197 Sandra Philipp 18 Special therapeutic aspects, 214 Wolfram Sterry 19 Combination treatments, 221 Peter C.M. van de Kerkhof 20 Optimizing adherence to treatment, 228 Frank Bachmann 21 Psoriasis therapy in children, 233 Sandra Philipp 22 Therapy of psoriasis during pregnancy, 241 Sandra Philipp 23 Recent and future developments in targeted therapy, 249 Caitriona Ryan and Alan Menter Index, 268

About the Author :
Wolfram Sterry, MD, Professor of Dermatology, Venereology and Allergy, University Hospital Charité, Berlin, Germany. Robert Sabat, MD, Head of Psoriasis Research and Treatment Center, Department of Dermatology and Allergy/Institute of Medical Immunology, University Hospital Charité, Berlin, Germany. Sandra Philipp, MD, Senior Physician, Psoriasis Research and Treatment Center, Department of Dermatology and Allergy/Institute of Medical Immunology, University Hospital Charité, Berlin, Germany