Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients

The first book focusing specifically on frequent and frequently disabling side effects involving the skin, hair and nails in cancer patients According to the World Health Organization, there are approximately thirty million people living with a diagnosis of cancer – the majority of whom will receive surgery, systemic therapy, and/or radiation, and who will suffer from dermatologic adverse events. Dermatologists and oncologists are only beginning to grapple with these events, which pose serious quality-of-life issues with so many patients, and will become more prevalent as survival rates improve, thanks in part to new cancer treatments and drug regimens. Concentrating on a topic that has only been briefly touched upon by other texts, this book offers a focused perspective on the clinical presentation, underlying pathophysiologic mechanisms, and management of skin, hair, and nail conditions for oncologists, dermatologists, and allied practitioners. Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients: • Covers in detail the dermatologic adverse events of oncologic therapies, clinical presentations, and treatment recommendations • Enables dermatologists and other practitioners to significantly improve the care of patients with cancer • Addresses the dermatologic adverse events of cancer therapies used globally, of which a large number are found in developing countries • Emphasizes prophylactic measures – based on treatments used and type of cancer – to prevent the appearance of adverse events • Provides built-in discussions on patient education for practical counseling during therapies • Offers rapid-reference sections on topical dermatology drugs The first book to present dermatologic conditions in cancer patients and survivors in a uniform and in-depth manner, Dermatologic Principles and Practice in Oncology is ideal for oncologists, oncology nurses, and dermatologists who wish to take better care of those with adverse skin, hair, and nail conditions.

Table of Contents:
List of Contributors vii Preface x Section 1 Dermatology and Oncology 1 Epidemiology and Burden of Disease 3 Beth N. McLellan, Devika Patel and Mario E. Lacouture 2 The History of Supportive Oncodermatology 17 Yevgeniy Balagula, Steven T. Rosen and Mario E. Lacouture 3 Structure and Function of the Integumentary System and the Dermatology Lexicon 24 Emmy Graber and Amit Garg 4 Types of Dermatologic Reactions 33 Raed O. Alhusayen, Sandra R. Knowles and Neil H. Shear 5 Grading Dermatologic Adverse Events in Clinical Trials Using CTCAE v4.0 47 Alice Chen, Asha Acharya and Ann Setser 6 Psychosocial Issues in Oncology: Clinical Management of Psychosocial Distress, Health-Related Quality of Life, and Special Considerations in Dermatologic Oncology 60 Lynne I. Wagner and David Cella 7 Dermatopathology 69 Molly A. Hinshaw and James L. Troy Section 2 Cancer-Related Dermatologic Disorders 8 Paraneoplastic, Inherited Cancer Syndrome, and Environmental Carcinogen-Related Dermatoses 77 Cindy England Owen and Jeffrey P. Callen Section 3 Dermatologic Conditions During Cancer Therapy 9 Oral Mucosal Complications of Cancer Therapy 89 Stephen T. Sonis 10 Hair Disorders Associated with Anticancer Agents 100 Caroline Yeager and Elise A. Olsen 11 Nail Abnormalities in Oncology Practice 115 Robert Baran, Bernard Fouilloux and Caroline Robert 12 Pruritus 122 Tejesh Patel and Gil Yosipovitch 13 Management Options for Hot Flashes in Cancer Patients 131 Amanda R. Moraska and Charles L. Loprinzi Section 4 Skin Toxicities to Chemotherapy 14 Alkylating Agents 147 Elisabeth Livingstone, Lisa Zimmer, Larissa Leister and Dirk Schadendorf 15 Antimetabolite Reactions 160 Emily Y. Chu and Heidi H. Kong 16 Topoisomerase-Interacting Agents 170 Tomas Skacel, Roger von Moos and Reinhard Dummer 17 Epidermal Growth Factor Receptor Inhibitor Reactions 184 Yevgeniy Balagula and Mario E. Lacouture 18 Small Molecule Multikinase Inhibitors 196 Caroline Robert, Vincent Sibaud and Christine Mateus 19 Antimicrotubule Agents 208 Claus Garbe 20 Histone Deacetylase Inhibitors, Proteasome Inhibitors, Demethylating Agents, Arsenicals, and Retinoids 215 Najla Al-Dawsari, Shannon C. Trotter and Francine Foss 21 Miscellaneous Reactions 224 Katharina C. Kaehler, Christine B. Boers-Doets, Mario E. Lacouture and Axel Hauschild 22 Skin Toxicities due to Biotherapy 233 Kathryn T. Ciccolini, Katharina C. Kaehler, Mario E. Lacouture and Axel Hauschild 23 Monoclonal Antibodies 241 Caroline Robert 24 Endocrine Agents 248 Katherine Szyfelbein Masterpol, Maura Dickler and Mario E. Lacouture 25 Agents for the Management of Hematologic Reactions 257 Mee-young Lee and Caroline C. Kim 26 Radiation-Induced Skin Reactions 264 Rebecca K.S. Wong and Zahra Kassam 27 Hematopoietic Stem Cell Transplantation and Graft Versus Host Disease 281 Stephanie W. Hu and Jonathan Cotliar 28 Extravasation Reactions 295 Seppo W. Langer 29 Topical Anticancer Therapies 301 Patricia L. Myskowski 30 Life-threatening (Serious) Dermatologic Adverse Events 310 Milan J. Anadkat 31 Dermatologic Infections 319 Yevgeniy Balagula, Mario E. Lacouture and James I. Ito Section 5 Late Cutaneous Events from Cancer Treatment 32 Late Dermatologic Conditions 339 Jennifer Nam Choi Section 6 Dermatologic Practice in Oncology 33 Management Algorithms for Dermatologic Adverse Events 367 Alyx Rosen, Iris Amitay-Laish and Mario E. Lacouture 34 Dermatologic Therapeutics and Formulations 384 Judy H. Borovicka, Jennifer R.S. Gordon, Ann Cameron Haley, Nicole E. Larsen and Dennis P. West 35 Dermatologic Techniques and Procedures 401 Robert Eilers Jr., Kishwer S. Nehal and Erica H. Lee 36 Appearance-Related Concerns in the Cancer Patient 410 Amy J. Derick Index 417  

About the Author :
Mario E. Lacouture, MD, is Associate Attending Dermatologist in the Department of Medicine at the Memorial Sloan-Kettering Cancer Center in New York City. He is a well recognized international authority on skin conditions in cancer patients, His clinical focus is the recognition and management of the side effects and conditions of the skin, hair, and nails that may arise in cancer patients and survivors as a consequence of surgery, chemotherapy, radiation, or transplantation. In 2012 published a well-received book for patients on this subject, Dr. Lacouture's Skin Care Guide for People Living With Cancer (Harborside Press).