This book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour therapy, antiantigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy, and tolerance during various autoimmune diseases.
Table of Contents:
Introduction (Mitchison). Mechanisms of peripheral T cell tolerance (L. Parijs, et al.).
B cell antigen receptor signalling in the balance of tolerance and immunity (Cirnall and FGoodnow).
General discussion I.
The study of self-tolerance using murine haemoglobin as a model self antigen (Williams and Allen).
Tolerance and determinant hierarchy (Schnieder et al).
Molecular genetic studies in lymphocyte apoptosis and human autoimmunity (Martin, et al.).
General discussion II.
A Role for CTLA-4-mediated inhibitory signals in peripheral T Cell tolerance? (Allison, et al).
Antigen-specific CD4+ Tcells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defect (pape et al).
Antigen-specific tolerance induction and the immunotherapy of experimental autoimmunity disease (Anderton, et al.).
Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes (Healy, et al.).
Tolerance induction with CD4 monoclonal antibodies (Waldmann et al).
Cross-presentation of self antigens to CD8+ Tcells: the balance between tolerance and autoimmunity (Kurts et al).
General discussion III.
Tolerance induction in mature T lymphocytes (Alferink, et al.).
T lymphocyte-mediated control of autoimmunity (E. Shevach, et al.).
Final General Discussion.
Indexes.
About the Author :
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
