Memory Concepts 1993: Basic and Clinical Aspects - Proceedings of the 7th Novo Nordisk Foundation Symposium, Copenhagen, Denmark, 28-30 June 1993(v. 1036 International Congress S.)

This book is based on a meeting attended by 60 leading neuroscientists focusing on memory research. Current theories on the biological basis for learning were examined in the light of recent experimental evidence. Which underlying mechanisms and molecular changes are behind the different types of learning? How are memories stored and retrieved? What are the basis for failing memory? These were some of the questions addressed. This authoritative overview by some of the best researchers in the field on experimental and clinical memory problems, covers aspects from the psychological analysis of teaming and memory types to molecular scientific studies of the underlying causes.

Table of Contents:
Memory - Descriptions and Definitions. Declarative and nondeclarative memory: Multiple brain systems supporting Teaming and memory (L.R. Squire). Human memory (E. Tulving). The need for a functional analysis of spatial and other kinds of memory to interpret lesion-induced dissociations (R.G.M. Morris). Molecular devices of teaming: Types and tokens (Y. Dudai). Discussion. Biological Memory Models. The switch from short- to long-term facilitation at the connections between sensory and motor neurons of the gill-withdrawal reflex in aplysia (E.R. Kandel). teaming and memory in Drosophila (E.M.C. Skoulakis, P.-L. Han, R.L. Davis). Auditory teaming in owls (M.S. Brainard, E.I. Knudsen). Cerebellar function in normal movement and in motor teaming (M. Glickstein). Discussion. Models for Cellular Memory in Mammals. The role of intercellular messengers in -term potentiation (T.V.P. Bliss,M.L Errington,M.S Fazeli, Y-G. Li, K.P.S.J. Murphy, J.H Williams). Postsynaptic changes in LTP (Z.A. Bortolotto, G.L. Collingridge). Associative properties of long-term potentiation (H. Wigstrom, F. Asztely, M.-Y.Xiao). The presynaptic nature of hippocampal mossy fiber long-term potentiation( R.A. Nicoll, M.G Weisskopf). Properties of long-term depression in the cerebellum ( M. Ito). Synaptic mechanisms of cerebellum long-term depresion ( F.Tempia, A. Konnerth). Discussion.Neocortical Substrates for Learning and Memory. Cortical representation of learned behaviors ( M.M Merzenich, W.M Jenkins). Strategies for the formation and remodelling of local circuits in visual cortex (L.C. Katz). Neocortical memory cells and circuits (P.S. Goldman-Rakic). Synapse growth as a mechanism for activity-dependent synaptic modification (0. Steward). Discussion. Memory - Disease Mechanisms and Remedies. Amyloid deposition as the central event in the aetiology and pathogenesis of Alzheimer's disease (J. Hardy, K. Duff). Neurodegeneration, memory loss and prion diseases (S.B. Prusiner). Amino acid neurotransmitters in Alzheimer's disease: Focus on AMPA and GABA receptors (P.Krogsgaard-Larsen, P. Wahl, A. Schousboe, J.J. Hansen). Update on memory disorders (A.R. Damasio, D. Tranel, H. Damasio). Reafferentation of the subcortically denervated hippocampus: A model for transplant-induced functional recovery in the CNS (A. Bjorklund, O.G. Nilsson, P. Kalen). Discussion. Epilogue. A critical view of neuronal models of Teaming and memory (J.-P. Changeux). Author index. Subject index.