Intracerebral Transplantation in Movement Disorders: Experimental Basis and Clinical Experiences - Proceedings of the 20th Fernstrom Symposium, Lund, Sweden, 20-22 June 1990(v. 4 Restorative Neurology)

The development of the clinical application of cell transplantation to the central nervous system is currently in a very dynamic phase. Nevertheless, it needs to be emphasized that neural grafting still constitutes an experimental approach and not a therapy. It is highly important to maintain a close contact and interaction between clinical and animal experimental research. Unfortunately, there is a risk that the clinical trials do not have a solid experimental base and that they are performed in a manner that does not permit a stringent scientific evaluation of the results. This book, as was the aim of the symposium on which it is based, creates a dialogue between representatives of basic neuroscience and clinical research in order to promote the further development of intracerebral transplantation into a therapy in movement disorders.

Table of Contents:
Part 1. Experimental Basis. 1. Grafting strategies in Parkinson's Disease: the chromaffin alternative (L. Olson et al.). 2. Adrenal medullary transplants in primates (D.M. Gash et al.). 3. Nigral transplants in primate models of parkinsonism (S.B. Dunnett and L.E. Annett). 4. What we have learned from primate research (R.A.E. Bakey). Part II. Clinical Results. 5. Fetal neural implants for Parkinson's disease: results at 15 months (C.R. Freed et al.). 6. Stereotactic implantation of foetal mesencephalon (E.R. Hitchcock et al.). 7. Can an analogy be drawn between the clinical evolution of Parkinson's patients who undergo autoimplantation of adrenal medulla and those of fetal ventral mesencephalon transplant recipients? (J.J. Lopez-Lozano et al.). 8. Transplantation of human fetal mesencephalic tissue in caudate nucleus as treatment for Parkinson's disease: the Cuban experience (H. Molina et al.). 9. Intracerebral transplantation of fetal dopamine neurons in Sweden: clinical experiences from four patients with idopathic Parkinson's disease (O. Lindvall). 10. Fetal ventral mesencephalon brain homotransplantation in Parkinson's disease: the Mexican experience (I. Madrazo et al.). 11. General Discussion. Part III. General Aspects on Intracerebral Transplantations in Movement Disorders. 12. Selection criteria for CNS grafting into Parkinson's disease patients (R.A.E. Bakey). 13. The stereotactic approach for transplantation to the human brain (E.-O. Backlund). 14. Transplantation techniques. Open microsurgery for human brain transplantation: experience in the treatment of Parkinson's disease (I. Madrazo et al.). 15. General Discussion. 16. Human cadaver embryonic substantia nigra grafts: effects of ontogeny, preoperative graft preparation and tissue storage (T.B. Freeman and J.H. Kordower). 17. Grafting of human fetal brain tissue: a practical guide (P. Brundin and H. Sauer). 18. The immunology of rejection (P.J. Morris). 19. Survival of human foetal grafts in a rat model of Parkinson's disease; Alternative methods of immunosuppression (D.J. Clarke et al.). 20. Assessment of function and survival of intracerebral transplants (R. Freedman et al.) 21. Intracerebral transplantation studied with positron emission tomography (G.V. Sawle et al.). 22. Round table discussion. Key issues in intracerebral transplantation in movement disorders (C.D. Marsden, Chairman). 23. Core assessment program for intracerebral transplantations, CAPIT (J.W. Langston et al.). Part IV. Free Communications. 24. The relationship between symptoms and functional anatomy in the chronic neurodegenerative diseases: from pharmacological to biological replacement therapy in Huntington's disease (O. Isacson et al.). 25. Genetically modified cells: potential therapeutic application to Parkinson's disease (F.H. Gage et al.). 26.