Genetic Strategies in Epilepsy Research
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Genetic Strategies in Epilepsy Research: (v. 4 Epilepsy Research Supplements)

Genetic Strategies in Epilepsy Research: (v. 4 Epilepsy Research Supplements)


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About the Book

Research on the correlation between genetics and epilepsy is undergoing significant change. Advances in neurochemistry, cell biology, and molecular genetics are making hypotheses about the role of genetics in epileptogenesis more testable. In this book are reported the results of the third international conference held on genetics and epilepsy in June 1990 in Minnesota. Genetic Strategies in Epilepsy Research is divided into three sections: The first section deals with current knowledge of clinical and epidemiological studies; in particular, the relationship between underlying genetic entities and the present classification system for epilepsies and epileptic syndromes. The second section focuses on seven major databases which have helped formulate the hypotheses currently under test in family studies and genetic analysis, which are available for further analysis. One of the clearest advances made between two earlier workshops and this present conference was the mapping of two genetic loci for different types of epilepsy to specific chromosomes.

Table of Contents:
Acknowledgements/Preface. I. CLINICAL AND EPIDEMIOLOGICAL STUDIES 1. The challenging genetics of epilepsy (R.J. DeLorenzo). 2. The phenotype: Seizures and epilepsy syndromes (P. Wolf). 3. The use and role of EEG in the genetic analysis of epilepsy (T.A. Pedley). 4. Risk factors for epilepsy (W.A. Hauser and J.F. Annegers). 5. Epidemiological studies of epilepsy and their contribution to genetics (S. Shorvon). 6. Age specificity of seizure expression in genetic epilepsies (S. Shinnar and S.L. Moshe). II. FAMILY STUDIES AND GENETIC ANALYSIS 7. Family studies of epilepsy (V.E. Anderson, S.S. Rich, W.A. Hauser and K.J. Wilcox). 8. Syndrome-related genetics in generalized epilepsy (G. Beck-Mannagetta and D. Janz). 9. A genetically determined basic mechanism in benign partial epilepsies and related nonconvulsive conditions (H. Doose and W.K. Baier). 10. Genetic studies of febrile convulsions (T. Tsuboi). 11. Genetic studies in the epilepsies: The Montreal experience (E. Andermann). 12. The use of analytical epidemiologic methods in the family studies of epilepsy (J.F. Annegers). 13. The choice of epilepsy syndromes for genetic analysis (A.V. Delgado-Escueta, D.A. Greenberg, K. Weissbecker, A. Liu, L.J. Treiman, R. Sparkes, M.S. Park, A. Barbetti and P.I. Terasaki). 14. Genetic analysis of multivariate traits (R.C. Elston). 15. Epilepsy in mitochondrial encephalomyopathies (S. DiMauro, E. Ricci, M. Hirano and D.C. De Vivo). 16. The discovery of epilepsy genes by genetic linkage (M. Leppert, V.E. Anderson and R. White). 17. Recent advances in genetics (G.A. Evans). EXPERIMENTAL NEUROGENETICS 18. Mutational analysis of spike-wave epilepsy phenotypes (J.L. Noebels). 19. Molecular approaches to genes of the CNS (J.G. Sutcliffe, G.H. Travis, P.E. Danielson, K.K. Wong, H.P. Ottiger, F.H. Burton, K.W. Hasel, F.E. Bloom, S. Forss-Petter). 20. Seizures and the regulation of neurotrophic factor and neuropeptide expression in brain (C. Gall, J. Lauterborn, M. Bundman, K. Murray and P. Isackson). 21. Genetic analysis of ion channels in Drosophilia (B. Ganetzky). 22. Potassium channels and epilepsy: Evidence that the epileptogenic toxin, dendrotoxin, binds to potassium channel proteins (R.A. Newitt, K.M. Houamed, H. Rehm and B.L. Tempel). 23. Molecular characterization of the murine mutation myelin deficient (B. Popko). Subject index.


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Product Details
  • ISBN-13: 9780444812988
  • Publisher: Elsevier Science & Technology
  • Publisher Imprint: Elsevier Science Ltd
  • Height: 230 mm
  • Returnable: N
  • Weight: 936 gr
  • ISBN-10: 0444812989
  • Publisher Date: /12/1991
  • Binding: Hardback
  • Language: English
  • Series Title: v. 4 Epilepsy Research Supplements


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