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Caloric Restriction: A Key to Understanding and Modulating Aging: Volume 1(Volume 1 Research profiles in aging)

Caloric Restriction: A Key to Understanding and Modulating Aging: Volume 1(Volume 1 Research profiles in aging)


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About the Book

Caloric restriction has been proven to slow the aging process in rats and mice and is currently being studied in non-human primates. It is thought that if the biological mechanisms of the anti-aging action were uncovered, we would gain an understanding of the basic nature of the aging processes. This would, in turn, yield possible interventions in human aging. The question of how caloric restriction works is thus a major focus of research in biological gerontology. This title provides the growing number of researchers in this field with a detailed knowledge of what is known about caloric restriction within the frame of gerontology, as well as insights on the future of the field.

Table of Contents:
1. Overview. Historical Background of the CR Paradigm. Animal Taxa Studied. Study Designs. Anti-Aging Action. Dietary Factor. 2. Mortality Characteristics. Survival Curves and Related Data. Gompertzian Analyses. Age of Initiation and Duration of CR. Temporal Pattern of Food Intake. 3. Molecular and Cellular Biology. Stability of the Nuclear Genome. Gene Expression. Mitochondrial Function. Membrane Structure and Function. Protein Structure, Function, and Turnover. Cell Proliferation. Apoptosis. Cellular Signal Transduction. 4. Organismic Physiology. Body Composition. Nervous System. Locomotion and Skeletal Muscle. Cardiovascular System. Endocrines and Metabolism. Reproduction. Body Temperature Regulation. Immune Function. Wound Healing. 5. Age-Associated Diseases. Cancer. Kidney Disease. Cardiovascular Disease. Diabetes. Neurodegenerative Disease. Immune Disease. Cataracts and Glaucoma. Osteoarthritis. 6. Mechanisms of Anti-Aging Action of Caloric Restriction. Oxidative Damage Attenuation. Alteration of the Glucose-Insulin System. Alteration of the Growth Hormone-IGF-1 Axis. Hormesis. 7. Evolution of Anti-Aging Action of Caloric Restriction. Evolutionary Biology of Aging. The Female Reproductive Life Span Hypothesis. The Energy Apportionment Hypothesis. The Hibernation-Like Hypothesis. Computer Modeling. Testing Hypotheses. 8. Caloric Restriction Mimetics. Chemical Agents. Alteration of Physical Activity. Genetically Engineered Mice.


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Product Details
  • ISBN-13: 9780444511621
  • Publisher: Elsevier Science & Technology
  • Publisher Imprint: Elsevier Science Ltd
  • Height: 234 mm
  • No of Pages: 192
  • Sub Title: Volume 1
  • Width: 156 mm
  • ISBN-10: 0444511628
  • Publisher Date: 20 Dec 2002
  • Binding: Hardback
  • Language: English
  • Series Title: Volume 1 Research profiles in aging
  • Weight: 503 gr


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Caloric Restriction: A Key to Understanding and Modulating Aging: Volume 1(Volume 1 Research profiles in aging)
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