Cell-surface Aminopeptidases: Basic and Clinical Aspects: Proceedings of the International Conference on Cell-Surface Aminopeptidases, Nagoya, Japan, 15-17 August 2000(v. 1218 International Congress S.)

This book offers unique content for both basic and clinical scientists around the world with an interest in cell-surface peptidases. The book focuses on five cell-surface peptidases, namely neutral endopeptidase (NEP)/CD10, aminopeptidase N (APN)/CD13, aminopeptidase A (APA)/BP1, dipeptidyl peptidase IV (DPPIV)/CD26, and placental leucine aminopeptidase (PLAP)/insulin-regulated aminopeptidase (IRAP), which are members of the type II membrane-bound peptidase family. It reviews the recent progress in these peptidases as well as their peptide substrates, and explores their physiological and pathological significance. Key features include: a new insight into the regulation of blood pressure and peripheral vascular systems; research into a new mechanism for insulin-responsive glucose transport and its application for the treatment of diabetes; and understanding of the new mechanisms of cell-survival peptidase involvement in human tumor progression.

Table of Contents:
Preface. Editorial Review. Placental cell surface-aminipeptidases as a feto-maternal barrier (S. Mizutani). Cell-surface peptidases in health and disease: old enzymes and new developments (A.J. Turner). Aminopeptidase in cardiovascular systems. Importance of aminopeptidase A in the central control of arterial blood pressure (X. Iturrioz et al.). Physiological significance of conversion of angiotensin II to III by aminopeptidase A (J.W. Wright, J.W. Harding, S. Mizutani). Regulation of aminopeptidase A activity by Angiotensin II: possible role in animal models of hypertension (D.P. Healy). Expression of dipeptidyl peptidase IV in capillary endothelial cells and angiogenesis in rat heart (T. Koyama). Aminopeptidase in the immune system. Aminopeptidase A(APA/BP-1): an immunological overview (J. Wang et al.). Pipetidyl Peptidase IV/CD 26 and Aminopeptidase N/C13 in Regulation of Immune Response (S. Ansorge et al.). Molecular basis for CD26 mediated T cell costimulation (C. Morimoto et al.). CD13/aminopeptidase N: a novel chemoattractant for T lymphocytes in pulmonary sarcoidosis (K. Tani et al.). Cell-surface peptidases in cancer and apoptosis. Neutral endopeptidase and other peptidases such as aminopeptidase A and dipeptidyl peptidase IV in the development and progression of cancer (D.M. Nanus et al.). Transcriptional regulation of CD13/APN in myeloid cells and angiogenic endothelium (S.P. Hegde et al.). Expression of aminopeptidase A and neutral endopeptidase in human gestational trophoblastic neoplasms (K. Ino et al.). Inhibitory effect of ubenimex on the invasion of uterine cervical carcinoma cells and their production and activation of gelatinase A (MMP-2) (M. Ueda et al.). Bestatin, an inhibitor of aminopeptidases; preclinical and clinical studies (F. Abe et al.). Expression of dipeptidylpeptidase IV (DPPIV/CD26) in human mesothelial cells (H. Kajiyama et al.). A cell motility inhibiting monoclonal antibody MH7-5, which recognizes aminopeptidase N: its expression in colon cancer (H. Hashida et al.). Effects of zinc on physiology activity of aminopeptidase N overexpressed in human cancerous prostate tissues (K. Ishii et al.). CD13 is resistance mechanism for endothelial interleukin - 8 inducing apoptosis (Y. Mishima et al.). Induction of apoptosis by aminopeptidase inhibitors including bestatin in human tumor cell lines (K. Sekine et al.). Damage induced neuronal endopeptidase is a unique metallopepatidase involved in nerve injury (S. Kiryu-Seo et al.). Adrenal gland tumors are associated with altered enkephalinase activity of neutrophils and lipid peroxidation content in the plasma (T. Balog et al.). Cell-surface peptidase in reproductive medicine. Aminopeptidase A / angiotensinase: a new cell surface peptidase in human endometrium (H. Ando et al.). Bestatin, an inhibitor of aminopeptide N, enhanced follicular growth in mice (H. Fujiwara et al.). Dipeptidyl peptidase IV activity is involved in the mediation of stress-induced murine abortion (M. Hildebrant et al.). Is endothelin converting enzyme-1 the new regulator of corpora lutea? (S. Yoshioka et al.). Aminopeptidase A/angiotensinase induction by progesterone in choriocarcinoma cells (Y. Katsumata et al.). Neutral endopeptidase acts as a differentiation marker of human choriocarcinoma cells (C. Uehara et al.). Insulin-regulated aminopeptidase (IRAP)/oxytocinase and glucose transport. The insulin-regulated membrane aminopeptidase (S.R. Keller). Compartmentalization of the insulin - responsive aminopeptidase in PC12 cells (G. Thoidis, K.V. Kandror). Proteins associated with insulin-regulated aminopeptidase in insulin sensitive tissues: a possible role in anchoring GLUT4 (Y. Oka, T. Yamada). Biochemical characterization of placental leucine aminopeptidase/oxytocinase and its related enzyme, adipocyte-derived leucine aminopeptidase (M. Tsujimoto, H. Matsumoto, A. Hattori). Insulin-regulated aminopeptidase (EC 3.4.11.3), a gluzincin aminopeptidase (T. Kristensen et al.). Structural organization of the 5'-end of human placental leucine aminopeptidase (T. Ito et al.). Oxytocin regulates oxytocinase of human vascular endothelial cells (H. Nakamura et al.). Cleavage of peptide hormones by placental leucine aminopeptidase/oxytocinase (H. Matsumoto et al.). Structural and gene expression studies of cell-surface peptidases. DPPIV/CD26: Structural and biological characteristics of asparagine and cysteine mutants (H. Fan, J. Dobers, W. Reutter). Molecular biology of aminopeptidase N - structural predictions and tissue-specific transcriptional regulation (J. Olsen, A. Kehlen). Alternate promoters control tissue specific and development expression of the gamma glutamyl transpeptidase gene (Y. Laperche). Molecular cloning and characterization of adipocyte-derived leucine aminopeptidase (A. Hattori et al.). A HNF-3 binding element in the APN promoter is required for high - level lung expression (J.H. Heidecker, U.K. Nair, J.D. Funkhouser). Molecular cloning and expression of the silkworm aminopeptidase N isozymes as receptors for cry toxins (K. Tsukamoto et al.). Regulation of the human dipeptiyl peptidase IV gene by HNF-1alpha and beta during Caco-2 cell differentiation (Y.S. Kim, R.H. Erickson, R.S. Lai). Cell and medical biology of cell-surface peptidases. Aminopeptidase B: cellular localisation, biochemical and molecular properties (S. Cadel T. Foulon et al.). Radioautographic localization of APN in rat using a125I labelled selective inhibitor (H. Chen et al.). Comparison of plasma membrane - cleaving sites of human serum DPP IV and APN (S. Iwaki-Egawa, Y. Watanabe). DPPIV-inhibition as treatment of type II diabetes (T. Hoffmann et al.). Enhancement of brush border peptides activity in rat jejunum during starvation (T. Ihara et al.). Some properties of bacterial dipeptidyle peptidase IV (M. Ryo). Amyloid precursor protein is secreted by membrane-anchored metalloprtease ADAM9 (N. Hotoda et al.). Blood plasma total enkephalinase activity depends on human personality (O.Y. Sokolov et al.). Index of authors. Keyword Index.