ATP: From Neurotransmission to Cancer Therapy(Molecular Mediators in Health and Disease: How Cells Communicate)

ATP: Extracellular Communication in Health And Disease delivers a comprehensive discussion of extracellular ATP biology and its communication role in both homeostasis and pathologic states. It explores the function of ATP across the nervous, sensory, musculoskeletal, cutaneous cardiovascular, pulmonary, gastrointestinal, urinary, reproductive, exocrine, haematopoietic and immune systems. The book considers ATP in the context of various disease states, including cardiovascular, respiratory, psychiatric, inflammatory and neurodegenerative disorders, as well as pain and sensory disorders, infectious diseases, and cancer. ATP in humans is explored alongside other species, including rodents, fish, and plants. This is the latest volume in the “Molecular Mediators in Health and Disease” series. With contributions from specialists across pharmacology, physiology, biophysics, biochemistry, immunology, anatomy, molecular biology, therapeutics, and other critical fields, this volume provides a broad and detailed overview of ATP which will be helpful to researchers working in these areas and beyond.

Table of Contents:
Part I - Introduction to extracellular ATP 1. History of ATP and purinergic signalling 2. Extracellular ATP in normal biology Part II – Molecular biology of extracellular ATP signalling 3. Extracellular ATP 4. P2X receptors 5. P2Y receptors 6. Regulation of extracellular ATP by ectonucleotidases Part III – Extracellular ATP in organ function 7. Extracellular ATP and the oral cavity 8. Extracellular ATP and blood vessels 9. Extracellular ATP and the heart and carotid body 10. Extracellular ATP and the lung 11. Extracellular ATP and metabolism 12. Extracellular ATP and the gastrointestinal tract 13. Extracellular ATP and the liver 14. Extracellular ATP and the pancreas 15. Extracellular ATP and the kidneys 16. Extracellular ATP and the bladder 17. Extracellular ATP and the central nervous system 18. Extracellular ATP and the peripheral nervous system 19. Extracellular ATP and the eye 20. Extracellular ATP and the ear 21. Extracellular ATP and the reproductive organs 22. Extracellular ATP and the skin 23. Extracellular ATP and the bone 24. Extracellular ATP and skeletal muscle 25. Extracellular ATP and haematopoietic stem and progenitor cells 26. Extracellular ATP and platelets 27. Extracellular ATP and red blood cells 28. Extracellular ATP and innate immune cells 29. Extracellular ATP and adaptive immune cells Part IV - Pharmacology of extracellular ATP signalling 30. Extracellular ATP and P2X receptors) 31. Extracellular ATP and P2Y receptors Part V - Extracellular ATP in non-mammalian biology 32. Extracellular ATP in fish 33. Extracellular ATP in primitive species 34. Extracellular ATP in plants Part VI - Extracellular ATP in Disease 35. Extracellular ATP in aged-related disorders 36. Extracellular ATP in cardiovascular disorders 37. Extracellular ATP in respiratory disorders 38. Extracellular ATP in gastrointestinal disorders 40. 39. Extracellular ATP in brain diseases 41. Extracellular ATP in neurodegenerative disorders 42. Extracellular ATP in psychiatric disorders 43. Extracellular ATP in pain 44. Extracellular ATP in other sensory disorders 45. Extracellular ATP in infectious disease 46. Extracellular ATP in inflammatory disorders 47. Extracellular ATP in cancer 48. Extracellular ATP and future directions

About the Author :
Professor Ronald Sluyter received training in biochemistry and immunology. After completing his BAppSc (University of Technology, Sydney, Australia) and PhD (University of Sydney), he worked as a Research Fellow (2000-2003) and Senior Research Fellow (2003-2007) with the late Professor James Wiley at Nepean Hospital. Since 2008 he has held a tenured Aacdemic position at the University of Wollongong, being promoted to Professor in 2020. He is the author of over 137 original articles and book chapters. He has graduated over 16 graduate students. Dr Jennie Cederholm received training in biomedical science, physiology and neuroscience. After completing her MSc (Linköping University, Sweden) and PhD (University of South Australia, Adelaide), she worked as a Research Officer (2007-2011) in what is today Neuroscience Research Australia (NeuRA). In 2011, she joined the laboratory of Professor Gary Housley as a Postdoctoral Fellow at UNSW Sydney. She holds a tenured Academic position since 2020 and was promoted to Senior Lecturer in 2021. She is the author of 26 refereed scientific publications. She has graduated 8 Honours students and is currently supervising 2 Honours students and a PhD student. Associate Professor Leanne Stokes received training in physiology and pharmacology. After completing her MRes and PhD in immunology (University of Birmingham, UK), she worked as a postdoctoral researcher officer (2003-2006) at the University of Sheffield. In 2007, she joined the laboratory of the late Professor James Wiley as a Postdoctoral Fellow at University of Sydney before gaining independence through an NHMRC new investigator award (2009). In 2013 she moved to RMIT to take a position as a Vice-Chancellors Research Fellow (2013-2015). She holds a tenured Academic position since 2015 at the University of East Anglia (UEA) and was promoted to Associate Professor in 2020. She is the author of 54 refereed scientific publications. She has graduated 3 PhD students and is currently supervising an MSci student and a PhD student. Prof. H Ulrich is Full Professor and Head of the Laboratory of Neuroscience at the Institute of Chemistry of the University of São Paulo, Brazil. He is a pioneer in the investigation of purinergic signaling in neuroinflammation, neurogenesis and neurodegeneration. He is a founding member of the Brazilian Purine Club (Brazilian Society of Purinergic Signaling), Vice-President (2010-2012) and President (2012-2018 and 2021-2024) of the society and has chaired many congresses of the Brazilian Purine Club. He is Associate Editor of several peer-reviewed journals, including Purinergic Signalling. He has published more than 260 peer-reviewed manuscripts (>10,000 citations, H index: 52), 31 book articles and 5 books and is inventor in various patents. He was recently awarded with the Brazil Fulbright Global Health Chair at Rutgers Medical School. Associate Professor Srdjan Vlajkovic received training in medicine, immunology, and neuroscience. He worked at the Department of Physiology, University of Auckland as a Research Fellow and Senior Research Fellow and now holds a tenured academic position at the University of Auckland. He authored 88 original articles and book chapters and supervised 38 graduate students to completion. Dr Vlajkovic guest-edited several Special Issues in international journals and is currently the Academic Editor of the International Journal of Molecular Sciences and Frontiers journals. Prof. Y Tang is a Full Professor and Dean of the School of Health and Rehabilitation of Chengdu University of Traditional Chinese Medicine. He is the founding member of the International Joint Research Center on Purinergic Signalling of Sichuan Province of China and the Co-chair of China Purine Club. He is Associate Editor of Purinergic Signalling. He is the author of over 157 publications and book chapters. He has graduated over 29 graduate students.