Reconstructive Transplantation and Regenerative Surgery: Volume 3 The New Frontier(Volume 3 Regenerative and Transplant Medicine)

Reconstructive Transplantation and Regenerative Surgery: The New Frontier, Volume Three in the Regenerative and Transplant Medicine series—explores this transformative discipline. This integration aims to overcome the limitations of traditional vascularized organ and tissue transplantation, offering innovative solutions through cutting-edge techniques. As regenerative surgery continues to evolve, this volume serves as a comprehensive resource, highlighting the latest advancements in graft immunomodulation, neuroregeneration, gene editing, diagnostic imaging, ischemia mitigation, and graft preservation. Authored by leading experts, this volume delves into crucial topics such as cell therapies, immunobiologics, neurobiologics, and targeted therapeutic strategies like local immunosuppressive implants and immunocloaking. It also covers cutting-edge diagnostic approaches, including non-invasive molecular imaging, nanotheranostics, and multimodal surveillance techniques. By addressing critical challenges in transplantation and regeneration, this book is an essential reference for surgeons, clinicians, trainees, scientists, and academics dedicated to advancing the field.

Table of Contents:
TABLE OF CONTENTS RECONSTRUCTIVE TRANSPLANTATION Part I – The Cutting Edge 1. The World’s Largest Single Center Experience in Face Transplantation Viola Stögner, Alexzandra Zdrava, and Bohdan Pomahac 2. Laryngotracheal Transplantation—Evolution and Experience Benjamin Laitman, and Eric Genden Part II – Unique Considerations and Emerging Indications 3. Lower Limb Transplantation - Pre-Clinical Insights and Patient Considerations Naga Anvesh Kodali, Omer Faruk Dirican, and Yalcin Kulahci 4. Penile Transplantation - Experience and Emerging Indications Janarthanan Ramu, Bedreddin Sazoglu, and Fatih Zor 5. Whole Eye Transplantation - Knowns and Unknowns Mariana Mayorquin, Gabriela Nava Márquez, Gustavo A. Rebolloso González REGENERATIVE SURGERY Part III – Targeted Technologies and Therapies 6. In-Situ, Implantable and Locally Injectable Drug Delivery - State of the Art Mishal Khan, Amogh Gorantla, and Praveen Kumar Vemula 7. Smart Sensors for Graft Health Monitoring Atul Sharma Vijay Gorantla, and Sameer Sonkusale 8. Opportunities in Covalent Tissue Modification for Graft-localized Drug Release Robert Kane, Johann Karunananthan, Michael Nicosa, Yalcin Kulahci, and Anna Valujskikh Part IV – Cellular and Regenerative Therapies 9. Cell Therapy and Immune Tolerance: State of the Art and Potential Applications in Reconstructive Transplantation Vinay Itte and David Leonard 10. Gene Editing Strategies for Immunomodulation Fatih Zor, Zeynep Demir, Vijay Gorantla, and Yalcin Kulahci Part V– Graft Preservation 11. Novel Oxygen Carrier Perfusates for Transplant Applications Vidya Surti, Amit Chandra Das, and Jelena Janjic 12. Preservation Technologies in Reconstructive Transplantation: Lessons from Solid Organ Experience Ellie Cohen, Josh Copus, and Varun Kopparthy Part VI – Tissue Engineering and Regenerative Biomaterials 13. Tracheal Tissue Engineering Çağdaş Duru and Siba Haykal 14. Thymus Tissue Engineering Gauri Kulkarni, Fatih Zor, Yalcin Kulahci, and Vijay Gorantla 15. Customized Bioresorbable Implants for Bone Fixation in Reconstructive Transplantation Matthew Criado, John Ohodnicki, Nikhita Joy, Mayur Gaikwad, Vijay Gorantla, and Prashant Kumta Part VII – Special Populations in Reconstructive Transplantation Hand and Face Transplantation in Teens and Young Adults - Unique Considerations Aarnav Gorantla and Mary Brooks Hall

About the Author :
Dr. Gorantla is a tenured professor of surgery at Wake Forest University School of Medicine and the Wake Forest Institute for Regenerative Medicine. He is the director of the Vascularized Composite Allotransplantation (VCA) Program at Atrium Health Wake Forest Baptist. His research interests include biosensors and biosensing techniques, cellular therapies, nanomedicine, organ transplantations, reconstructive surgeries, regenerative medicine and its applications in transplantation and regenerative, pharmacology. Additionally, he studies the relationship between the immune system and the regenerative, oncogenic and autoimmune processes. Dr. Gorantla was a key member of the team that performed the nation’s first hand transplant at the University of Louisville in 1999. He co-founded the first national society for VCA, the American Society for Reconstructive Transplantation (ASRT). Dr. Gorantla has authored more than 100 scientific papers and 15 book chapters in the field of VCA and is currently co-editing a comprehensive book on the subject of regenerative surgery. Dr. Yalcin Kulahci is a Plastic and Reconstructive Surgeon with specific expertise in Reconstructive Surgery and Microsurgery. He is dual board-certified in Oral and Maxillofacial Surgery and Hand Surgery and was recruited as faculty in 2008 to the Gulhane Military Medical Academy (GMMA) in Istanbul, affiliated with NATO and USUHS. In 2011, Dr. Kulahci was appointed as an Associate Professor at the same institution. In 2012, he became a founding academic staff member for the Department of Hand and Upper Extremity Surgery in Ankara, Turkiye. In 2019, he was recruited to the Wake Forest Institute for Regenerative Medicine following 22 years of honorable service with the Military Health System in Turkey. Dr. Kulahci is currently a faculty member at the Wake Forest School of Medicine and has a comprehensive publication record in clinical reconstructive surgery and microsurgery, with decades of translational research experience in VCA. Dr. Zor is a Plastic and Reconstructive Surgeon with specific expertise in Reconstructive Surgery and Microsurgery. He served as assistant professor of Plastic Surgery and chief combat surgeon in Turkish Armed Forces for over 15 years. Dr. Zor established the first military VCA programs in Turkey and obtained approval for both hand and face transplantation in 2011. Given his field experience in battlefield medicine and expertise in complex reconstruction, tissue regeneration, and hand/face transplantation, he was recruited to Wake Forest Institute for Regenerative Medicine as a faculty in 2017. He participated on several collaborative multi-institutional RTRP and PRMRP awards in the area of reconstructive transplantation and tissue generation. Currently, he's working as Burn Surgery Fellow in Indiana University School of Medicine. My research focus is on immunomodulation, non-invasive VCA monitoring, peripheral and optic nerve regeneration, nanomedicine applications involving transplant and tissue regeneration indications and multimodality imaging strategies for VCA.