Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies

Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology’s potential in revolutionizing drug delivery for colon-related ailments. Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges. Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein–peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system. Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors.

Table of Contents:
An Overview on Colonic Diseases Colonic disease – targeting strategies Nanocarriers for the colonic diseases Applications of nanocarriers in colon targeting Polymeric nanoparticles in colon targeting Polymersomes in colon targeting Polymeric micelles in colon targeting Solid lipid nanoparticles in colon targeting Nanostructured lipid carriers in colon targeting Liposomes in colon targeting Carbon-based nanomaterials in colon targeting Gold nanoparticles in colon targeting Supramagnetic iron oxide nanoparticles for colon targeting Magnetic triblock copolymer nanoparticles in colon targeting Dendrimer nanoparticles for colon targeting Mesoporous silica nanoparticles in colon targeting Redox nanoparticles in colon drug targeting Protein and peptides-based nanoparticles in colon targeting Hybrid nanoparticles in colon targeting Polysaccharides Based nanocarriers in colon targeting Nanocrystals based approach in colon targeting Nano-based enema’s for colon targeting Exosomes in colon targeting Nano carriers in Inflammatory Bowel Disease and Colorectal Cancer Self-Nano Emulsifying Drug Delivery Systems in Colon Targeting Pre-clinical and clinical status of different nanocarriers for colon targeting Regulatory issues and toxicological concerns related to nanocarriers

About the Author :
Lalit Kumar is an Assistant Professor in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education and Research, Hajipur, Vaishali, Bihar, India. His area of research includes the development of nanocarriers for drug-targeting tumor cells in the colon, brain, breast, and lungs. Yashwant Pathak is a Professor and Associate Dean for faculty affairs at the Taneja College of Pharmacy at the University of South Florida, Tampa, USA. Prof. Pathak is also an Adjunct Professor at the Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia. His area of research is in health care education, nanotechnology, drug delivery systems, and nutraceuticals.