About the Book
The Scientific Basis of Monkeypox: Features, Prevention, and Treatments advances understanding of monkeypox and provides a framework for future research with evidence-based and forward-looking content. Content makes use of modeling systems and current experiences derived from case studies to provide material that is cross-disciplinary, bridging interdisciplinary divides. Furthermore, consideration is given to the behavioral response to monkeypox infection, including barriers to vaccination. Each chapter contains structured content, including policy and procedures, applications to new or emerging communicable diseases, a mini dictionary of terms, and summary points.
Chapter contributions are from leading national and international specialists, including those from world renowned institutions who provide a global perspective. The book is a perfect reference for specialists in infectious diseases, virologists, microbiologists, health scientists, public health workers, doctors, pharmacologists, and research scientists.
Table of Contents:
Preface
Section 1: Setting the Scene and Introductory Chapters
1. A synopsis of mpox
2. Monkeypox unveiled: understanding its impact on public health
3. Human mpox (monkeypox) virus and its evolution
4. Importance of emerging lineages of mpox (monkeypox) virus: an updated narrative
5. Bridging borders: the collective fight against monkeypox outbreaks
6. Social media and the response to mpox (monkeypox)
Section 2: The Biology And Transmission Of mpox (monkeypox)
7. Monkeypox virus: fundamental features of its particle, replication cycle, cytopathic effects and research models
8. Biology of the mpox virus and the cysteine protease structures and basis of in silico studies
9. The serial interval distributions of the mpox virus infection
10. Investigating mpox: linking web tools and genomic analysis
11. Mathematical Modelling of Mpox: A Review
Section 3: Detection And Confirmation
12. Development, validation, and use of assays within the clinical diagnostic and Emergency Use Authorization/Food and Drug Administration (EUA/FDA) contexts
13. Primers and Probes for the Diagnostics of mpox (monkeypox) Virus
14. Monkeypox and wastewater surveillance: tracing the spread of a viral outbreak through environmental monitoring
Section 4: Effects On the Body. Tissues And Organs Systems
15. Time related change in skin lesions and their progression
16. Atypical skin manifestations of mpox
17. Variations in clinical features and symptoms in mpox (monkeypox) infection: fever and beyond
18. Otolaryngological features of mpox: lymphadenopathy, pharyngeal and airways
19. Cardiac involvement of mpox (monkeypox)
Section 5: Vaccinations, Treatments And Alleviation Of Symptomology
20. The psychological responses of mpox (monkeypox) virus vaccination in health care workers: international aspects
21. Immunoinformatics and mpox (monkeypox) virus vaccines
22. Barriers to mass vaccination against monkeypox: an overview
23. Approved and experimental antivirals for mpox
24. Repurposing drugs for monkeypox using artificial intelligence
25. Monkey Pox clinical management-A Review
26. Treating pustular skin lesions in viral infection: mpox and beyond
27. Treating concomitant HIV and mpox virus infection
Section 6: Case Studies
28. Case Study: Mpox (monkeypox) and a typical scenario of clinical presentation, diagnosis and successful treatment
29. Case Study: Heterosexual transmission of mpox
30. Case Report: Simultaneous presentation of human monkeypox virus and sexually transmited diseases (STDs): a diagnostic and management challenge
31. Case study: Anatomopathological findings in different mpox cutaneous lesions
32. Case Study: Scaring and quality of life in mpox
Section 7: Resources
33. Resources for the study and investigation of mpox (monkeypox)
About the Author :
Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.
Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.
Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.
Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.
Vinood B. Patel, BSc, PhD, FRSC, is currently Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress in neurological disorders and iron dysregulation in diabetes. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to the use or investigation of active agents or components. These books include The Handbook of Nutrition, Diet, and Epigenetics, Branched Chain Amino Acids in Clinical Nutrition, Cancer: Oxidative Stress and Dietary Antioxidants, Toxicology: Oxidative Stress and Dietary Antioxidants, Molecular Nutrition: Vitamins, The Neuroscience of Pain, Cognitive Behavioural Therapy. He is Editor of the ten-volume series Biomarkers in Disease: Methods, Discoveries and Applications. Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.
