Genome Analysis: Principles and Methods

Genome Analysis: Principles and Methods provides recent and advanced information about genome analysis approaches and techniques to study and annotate the structure and function of the genome. It is a compendium of important topics such as NGS analysis, genome fragmentation and assembly, metagenomics, cloning and expression, physical marker analysis, transcriptome data analysis, sequence alignment and comparison, evolutionary analysis, SNP analysis, genome-based disease diagnosis and therapies, micro-RNAs, pharmacogenomics, genetic approaches to disease intervention, and challenges with opportunities in genome analysis and genomics, etc. The latest developments in the field are discussed, and key concepts are introduced to ensure readers understand advanced concepts and methodologies in the area. The book serves as a valuable guide to the present, emerging, and evolving research methodologies in the field.

Table of Contents:
1. Introduction to genome analysis and genomics approaches Preeti Sharma, Parvez Singh Slathia, Nitika Jamwal, Ridhima Singh, Timir Tripathi and Vijay Pratap Singh 2. Genome complexity and genome organization Shiv Narayan and Sandeep Kumar 3. Databases for genome and genomic information Atifa Hafeez, Upasna Srivastava and Manish Kumar Gupta 4. Recent techniques and strategies for sequencing Pawan Kumar, Harjeevan Kaur, Ritika Bishnoi and Deepak Singla 5. Gene cloning and protein expression systems Manvendra Sengar, Vinita Ahirwar, Madhubala Rathore, Ashutosh Gupta, Abha Sachan, Neelam Kashyap and Ashutosh Tiwari 6. Physical Markers and Related Techniques for Marker Development Brajendra Shukla 7. Gene Expression Analysis Sarika Sahu, Soumya Sharma, Sneha Murmu, Ritwika Das and Priyanka Jain 8. Computational Approaches for Transcriptome Data Analysis Swarna Kanchan 9. Metagenomics Approaches Pramod Katara 10. Sequence Alignment and Comparison Tools Pramodkumar Gupta 11. Gene Prediction Approaches Noopur Singh and Amit Prakash Raghuwanshi 12. Single Nucleotide Polymorphism Analysis and Related Genetic Disorders Sanjay Kumar Singh, Atifa Hafeez and Manish Kumar Gupta 13. Genome annotation approaches Prekshi Garg, Sanjana Mishra, Prachi Srivastava and Farrukh Jamal 14. Genome Sequencing Projects and Major Outcomes Priyanka Rattan and Shikha Mittal 15. Human Genome Project and Current Status Akshita Chaudhary, Kritika, Anuja Bharmaik and Shikha Mittal 16. Micro-RNA Prediction Tools and Target Analysis Anshul Tiwari and Rinku Sharma 17. Mechanisms for Genetic Variations Vijay Pratap Singh, Parvez Singh Slathia, Preeti Sharma and Pushpendra Singh 18. Genome-based approaches for disease diagnosis Prachi Tiwari, Harshita Katiyar, Rajani Singh and Anuj Shukla

About the Author :
Dr. Dev Bukhsh Singh is currently an Assistant Professor in the Department of Biotechnology at Siddharth University, Kapilvastu, Siddharth Nagar, India since 2021. He also served as Assistant Professor in the Department of Biotechnology at Chhatrapati Shahu Ji Maharaj University, Kanpur, India from 2009-2021. He received BSc (Biology) and MSc from the University of Allahabad, an MTech from the Indian Institute of Information Technology, Prayagraj India, and a PhD in Biotechnology from Gautam Buddha University, India. He has been actively involved in teaching BSc and MSc Biotechnology students since 2009. His areas of research are medicinal biology, lead compound search, and drug design. He published three edited books: Frontiers in Protein Structure, Function, and Dynamics Computer-Aided Drug Design and Bioinformatics: Methods and Applications. He is a member of various national and international academic bodies and is a reviewer for several international journals. Professor Timir Tripathi is a Professor of Molecular Biology, School of Life Sciences, North-Eastern Hill University, Shillong, India. Earlier, he served as the Regional Director of Indira Gandhi National Open University. His previous role was Senior Assistant Professor and Principal Investigator at the Department of Biochemistry, NEHU, Shillong. He holds a Ph.D. from Jawaharlal Nehru University, New Delhi. His primary research focus is studying the conformational dynamics, interaction, and stabilization of the complexes formed by intrinsically disordered neuropathological protein aggregates, their properties of liquid-liquid phase separation, interaction, and roles in nucleocytoplasmic transport in neurodegenerative diseases. Professor Tripathi is an Associate Fellow of the Indian National Science Academy, New Delhi, and an elected member of the National Academy of Sciences, India, the Royal Society of Chemistry, and the Royal Society of Biology, UK