Tic Disorders and Tourette Syndrome: (Handbook of Clinical Neurology)

Tic Disorders and Tourette Syndrome is an essential resource that delves into the clinical aspects, treatments, and ongoing research related to tic disorders and Tourette syndrome. It covers a range of topics from primary to secondary and functional tics, providing differential diagnosis. The book is designed to offer foundational knowledge to neurologists, psychiatrists, neuropsychiatrists, and psychologists, while also catering to the needs of advanced readers. In addition to clinical presentations, the book discusses the epidemiology, etiology, and pathophysiology of tics, along with common neuropsychiatric comorbidities such as obsessive-compulsive disorder, ADHD, mood disorders, and intermittent explosive disorder. The volume also includes treatment options and clinical scales to evaluate tics, illustrated with video accompaniments and animal models.

Table of Contents:
1. Introduction 2. Georges Gilles de la Tourette in the history of tics Section 1. Clinical Diagnosis of Tics 3. Clinical presentation of tics and Gilles de la Tourette syndrome 4. Secondary Tics: Etiology, presentation and management 5. Functional tics and tic-like behaviors 6. Repetitive and restricted behaviors, habits, body-focused repetitive behaviors and motor stereotypies Section 2. Comorbidities in Primary Tic Disorders 7. OCD in primary tic disorders and Tourette syndrome 8. Attention-deficit/hyperactivity disorder in primary tic disorders and Tourette Syndrome 9. Explosive outbursts and Tourette Syndrome/Chronic tic disorder 10. Sleep in tic disorders and Tourette Syndrome 11. Autism spectrum and other neurodevelopmental disorders 12. Sexuality and sexual health in primary tic disorders Section 3. Etiology and Pathophysiology 13. Epidemiology of Tourette Syndrome 14. Genetics of tic disorders and Tourette Syndrome 15. Neuroimmunology of tics and Gilles de la Tourette syndrome 16. Animal models of Gilles de la Tourette syndrome and other tic disorders 17. Clinical neurophysiology of tics 18. Neuroimaging of tic disorders 19. Dopamine and other neurotransmitters 20. Premonitory urges and other sensory phenomena in primary tic disorders 21. Inhibitory control and voluntary tic suppression Section 4. Treatments 22. Behavioral treatments of tic disorders 23. Pharmacological treatments 24. Deep brain stimulation for Gilles de la Tourette syndrome 25. Non-invasive brain stimulation for Gilles de la Tourette syndrome 26. Treatment of neuropsychiatric comorbidities in tic disorders Section 5. Overview of patient organizations and other useful resources 27. Overview of support associations and other useful resources Section 6. Closing Remarks and Future 28. Closing remarks and future scope of unmet needs

About the Author :
Dr. Christos Ganos is a staff neurologist at UHN’s Krembil Brain Institute, Toronto Western Hospital, and an Associate Professor in the Division of Neurology at the University of Toronto, where he also holds the Wolf Family Chair in Neurodevelopmental Psychiatry. Born in Thessaloniki, Greece, he completed his medical training at the University Medical Center Hamburg-Eppendorf in Germany, followed by a three-year fellowship at the National Hospital for Neurology and Neurosurgery in London, and from 2017 to 2023 was a consultant in the Movement Disorder Unit at Charité – Universitätsmedizin Berlin. He specializes in hyperkinetic, neuropsychiatric, and rare or unusual movement disorders, with a particular focus on tic disorders. His research centers on the detailed characterization of clinical phenomena, the elucidation of their underlying pathophysiology, and the development and implementation of novel treatments. He is the founding chair of both the Tic Disorders Study Group and the Task Force on Tic Disorders of the International Parkinson and Movement Disorder Society (MDS). Yulia Worbe is a tenured Professor of Clinical Neurophysiology at Sorbonne University and serves as a consultant neurophysiologist and neurologist at Sorbonne University Hospitals, primarily at Pitié-Salpêtrière and Saint-Antoine. She specializes in the neurophysiology of movement disorders and has a longstanding interest in Tourette syndrome. Dr. Worbe graduated from the Medical University of St. Petersburg, Russia, where she completed her general neurology training. She subsequently specialized in movement disorders at Pitié-Salpêtrière Hospital in Paris. Her research on Gilles de la Tourette syndrome led to a PhD in Neuroscience from Sorbonne University, where she developed animal models of Tourette disorder. She completed two post-doctoral fellowships: one at Sorbonne University, focusing on basal ganglia and network dysfunction in Tourette disorder using neuroimaging, and another at the University of Cambridge's Behavioural and Clinical Neuroscience Institute, exploring serotonergic regulation of behavior using brain imaging. Prof. Worbe’s research centers on the cognitive and behavioral aspects of movement disorders, with a focus on Gilles de la Tourette syndrome and genetic dystonia. She investigates brain function in these disorders using cognitive testing, neuroimaging, and non-invasive neurostimulation techniques.