Handbook of PAF and PAF Antagonists
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Handbook of PAF and PAF Antagonists: (Routledge Revivals)

Handbook of PAF and PAF Antagonists: (Routledge Revivals)


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About the Book

Published in 1991: Since its characterization in the 1970s from antigen-stimulated rabbit basophils, platelet-activating factor (PAF) has been demonstrated to be produced by, and act upon, a variety of cell types. PAF antagonists, which have been obtained from both natural sources and chemical synthesis, now represent a new class of therapeutic agents and may provide new prospects for treating several major pathologies, particularly shock, ischemia and asthma. This book provides a unique overview of the chemistry, molecular modeling, pharmacology, and clinical potential of the major classes of natural and synthetic PAF antagonists. Compounds reviewed include the ginkgolides, diketopiperazines, neolignans, hetrazepines, cyclic and 1,3-dioxolan derived PAF analogs, pyrrolo[1,2-c]thiazoles, imidazo[2,1-a]isoquinolines and pyridoquinazoline carboxamides. Consisting of 12 chapters written by leading experts in PAF antagonist research, this book is essential reading for students, researchers, clinicians, and medical practitioners involved in this rapidly developing field of biomedical research.

Table of Contents:
Part 1: Natural PAF Antagonists 1. Recent Progress in PAF Antagonist Research 2. PAF Antagonists From Microbial Origin: Structure-Activity Relationship of Diketopiperazine Derivatives 3. Kadsurenone Type Neolignans, Potential PAF Antagonists: Chemistry and Distribution Part 2: Synthetic PAF Antagonists 4. Structure Activity Relationships CV-3988 and CV-6209 PAF Antagonists Series 5. Aminoacylates and Aminocarbamates of 2-Substituted 4-Hydroxymethyl 1,3-Dioxolans: Structure Activity Relationships and Biological Activity as PAF-Antagonists 6. GS 1065-180 and Related PAF Antagonists: Chemistry and Pharmacology 7. Structure Activity Relationships in Cyclic Analogs of PAF with PAF Antagonist Properties 8. Pharmacology of Hetrazepines as PAF-Antagonists 9. Structure-Activity Relationships in Pyrrolo [1,2-c] Thiazoles PAF Receptor 10. Structure Activity Relationships in 5-Aryl-2,3-Dihydroimidazo[2,la]Isoquinoline PAF Antagonists 11. N-[w-(Heteroaryl)Alkyl]Carboxamide Derivatives as Platelet Activating Factor Antagonists: Structure-Activity Relationships and Biological Data Part 3: Molecular Modeling 12. Structure Activities in PAF Acether Antagonist Series Using Molecular Lipophilic Potential Studies

About the Author :
Pierre Braquet Ph.D., D.Sc. is Director and General Manager of the Ipsen‐Beaufour pharmaceutical group at the Institut Henri Beaufour, Le Plessis Robinson, France and Professor at Louisiana State University, New Orleans, Louisiana.


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Product Details
  • ISBN-13: 9780429556449
  • Publisher: Taylor & Francis Ltd
  • Binding: Digital (delivered electronically)
  • No of Pages: 282
  • Series Title: Routledge Revivals
  • ISBN-10: 0429556446
  • Publisher Date: 13 Jun 2019
  • Language: English
  • No of Pages: 282


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