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Home > Mathematics and Science Textbooks > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > Chromosomes: The Complex Code
Chromosomes: The Complex Code

Chromosomes: The Complex Code


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About the Book

This text presents a concise account of modern cytogenetics. Basic facts are presented together with illustrative examples from plant, animal and medical cytogenetics. Selected references guide the reader to recent literature. The book emphasizes the revitalization of cytogenetics resulting from research into the human genome and the subject's integration with molecular biology. Classic cytogenetics is also discussed to give context to more recent studies. This book should be of interest to geneticists, cell biologists, molecular biologists, and students on undergraduate courses in a range of disciplines, medical and life science courses.

Table of Contents:
1 Chromatin structure and replication.- 1.1 Chromosome structure.- 1.2 Evidence that DNA is the genetic material.- 1.3 The double helix.- 1.4 The genetic code.- 1.5 DNA constitution.- 1.6 Higher order structure of DNA.- 1.7 Chromosome replication.- 2 Chromosome form and function.- 2.1 Structures in a chromosome.- 2.2 Heterochromatin.- 2.3 Telomeres.- 2.4 Centromeres and kinetochores.- 2.5 Nucleolar organizing regions.- 2.6 Lampbrush and polytene chromosomes.- 2.7 Double minutes and homogeneously staining regions.- 2.8 B chromosomes.- 2.9 Supernumerary segments.- 2.10 Artificial chromosomes.- 3 Chromosome identification.- 3.1 The karyotype.- 3.2 Chromosome banding.- 4 Nuclear division.- 4.1 Mitosis.- 4.2 The spindle apparatus.- 4.3 Meiosis.- 4.4 Chromosome pairing.- 4.5 Synaptonemal complex formation.- 4.6 Recombination nodules.- 4.7 Recombination and gene conversion.- 4.8 Meiosis in polyploids and structural rearrangements.- 4.9 Structural changes.- 5 Gene control by position and origin.- 5.1 Chromosome organization within the nucleus.- 5.2 Chromosomal imprinting.- 6 Mutagenesis.- 6.1 General ideas about mutagenesis.- 6.2 Changes associated with the environment.- 6.3 Chromosomal aberrations.- 6.4 Aneuploidies.- 6.5 Mutations affecting cell proliferation.- 6.6 Translocations.- 6.7 Fragile sites.- 6.8 Transposable elements.- 7 Chromosome mapping.- 7.1 Introduction.- 7.2 Genetic maps.- 7.3 Cytological maps.- 7.4 Correlation between genetic and cytological/physical maps.- 7.5 Mapping strategies.- 8 Sex chromosome systems.- 8.1 Heteromorphic sex chromosome systems.- 8.2 Mammalian sex chromosome systems.- 8.3 X inactivation.- 8.4 Mammalian sex chromosome evolution.- 8.5 Other sex chromosome systems.- 9 Evolution and speciation.- 9.1 Hybrids and cultivars.- 9.2 Speciation by karyotype changes.- 9.3 Speciation in an ancient mammalian group.- 9.4 Evolution of the hominids.- 10 Artificial manipulation of genomes.- 10.1 Manipulation of whole chromosome sets.- 10.2 Manipulationof single chromosomes.- 10.3 Manipulation producing variable genome changes.- 10.4 Single-gene transfer.- 11 Historical aspects of cytogenetics.

Review :
...an excellent introduction to cytogenetics covering chromosome structure and function, cell division, evolution, mutation, sex chromosome systems, and the artificial manipulation of genomes, with the emphasis on eukaryotes. - Aslib Book Guide; ...clear written style...accessible for the student audience...recommended as a reference... - The Biologist


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Product Details
  • ISBN-13: 9780412752100
  • Publisher: Chapman and Hall
  • Publisher Imprint: Chapman and Hall
  • Height: 297 mm
  • No of Pages: 346
  • Sub Title: The Complex Code
  • ISBN-10: 0412752107
  • Publisher Date: 30 Jun 1996
  • Binding: Hardback
  • Language: English
  • Returnable: Y
  • Width: 210 mm


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