Firestein & Kelley's Textbook of Rheumatology, 2-Volume Set

**Selected for 2025 Doody’s Core Titles® with "Essential Purchase" designation in Rheumatology** With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, Firestein & Kelley’s Textbook of Rheumatology remains your reference of choice in this evolving field. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. New editors, new chapters, and new illustrations keep you fully up to date on recent advances in genetics and the microbiome, current therapies, and other rapid changes in the field. Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, physical examination, and disease pathogenesis, manifestations and treatment?including key data on outcomes to better inform clinical decision making Includes new or significantly revised chapters on Pre-Clinical Autoimmunity; The Microbiome in Health and Disease; Physical Therapy and Rehabilitation; Nutrition and Rheumatic Disease; Classification and Epidemiology of Spondyloarthritis; Etiology and Pathogenesis of Osteoarthritis; COVID and Rheumatic Disease; Vaccination in Rheumatic Disease; Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer; and many more Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs; many new illustrations highlight diseases among racially diverse patients Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editors Drs. Ted Mikuls and Tuhina Neogi Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date

Table of Contents:
PART 1 Structure and Function of Bone, Joints, and Connective Tissue 1 Developmental Biology, Organization, and Function of the Synovial Joints 2 Synovium 3 Cartilage and Chondrocytes 4 Development and Biology of Bone 5 Muscle Anatomy, Physiology, and Biochemistry 6 Biomechanics 7 Regenerative Medicine and Tissue Engineering 8 Proteinases and Matrix Degradation PART 2 Cells Involved in Autoimmune Diseases and Inflammation 9 Dendritic Cells 10 Mononuclear Phagocytes 11 Neutrophils 12 T Lymphocytes 13 B Cells 14 Fibroblasts andFibroblast-like Synoviocytes 15 Mast Cells and Basophils 16 Innate Lymphoid Cells and Natural Killer Cells 17 Platelets and Megakaryocytes PART 3 Effector Mechanisms in Autoimmunity and Inflammation 18 Principles of Signaling 19 Innate Immunity 20 Adaptive Immunity 21 Immune Tolerance and Autoimmunity 22 Pre-clinical Autoimmunity 23 The Microbiome in Rheumatic Diseases 24 Genetics of Rheumatic Diseases 25 Epigenetics of Rheumatic Diseases 26 Complement System 27 Prostaglandins, Leukotrienes, and Related Compounds 28 Angiogenesis 29 Cytokines and Chemokines 30 Neuronal Mechanisms of Pain and Inflammation PART 4 Broad Issues in the Approach to Rheumatic Disease 31 Clinical Research Methods in the Rheumatic Diseases 32 Epidemiology and Impact of Rheumatic Diseases 33 Assessment of Health Outcomes 34 Biomarkers in Rheumatology 35 Occupational, Environmental, and Recreational Musculoskeletal Disorders 36 Cardiovascular Risk in Inflammatory Rheumatic Disease 37 Cancer Risk in Rheumatic Diseases 38 Occupational Therapy, Physical Therapy, and Rehabilitation 39 General Principles of Pregnancy and Rheumatic Disease: Pre-pregnancy Assessment PART 5 Evaluation of Generalized and Localized Symptoms 40 History and Physical Examination of the Musculoskeletal System 41 Ultrasound in Rheumatology 42 Evaluation of Monoarticular and Polyarticular Arthritis 43 Skin and Rheumatic Diseases 44 The Eye and Rheumatic Diseases PART 6 Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain 45 Neck Pain 46 Shoulder Pain 47 Low Back Pain 48 Hip and Knee Pain 49 Foot and Ankle Pain 50 Hand and Wrist Pain 51 Temporomandibular Joint Disorders 52 Fibromyalgia PART 7 Diagnostic Tests and Procedures in Rheumatic Diseases 53 Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology 54 Arthrocentesis and Injection of Joints and Soft Tissues 55 Anti-nuclear Antibodies 56 Autoantibodies in Rheumatoid Arthritis 57 Acute Phase Reactants 58 Imaging in Rheumatic Diseases PART 8 Pharmacology of Anti-rheumatic Drugs 59 Therapeutic Targeting of Prostanoids 60 Glucocorticoid Therapy 61 Traditional DMARDs: Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies 62 Immunosuppressive Drugs 63 Anti-cytokine Biologics 64 Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics 65 Janus Kinase and Other Intra-cellular Targets 66 Urate-Lowering Therapy 67 Bisphosphonates 68 Analgesic Agents in Rheumatic Disease 69 Nutrition and Rheumatic Diseases PART 9 Rheumatoid Arthritis and Sjögren’s Syndrome 70 Etiology of Rheumatoid Arthritis 71 Pathogenesis of Rheumatoid Arthritis 72 Clinical Features of Rheumatoid Arthritis 73 Treatment of Rheumatoid Arthritis 74 Sjögren’s Syndrome PART 10 Spondyloarthritis 75 Classification and Epidemiology of Spondyloarthritis 76 Axial Spondyloarthritis 77 Reactive Arthritis 78 Psoriatic Arthritis 79 Inflammatory Bowel Disease-Associated Arthritis and Other Enteropathic Arthropathies PART 11 Systemic Lupus Erythematosus and Related Syndromes 80 Etiology and Pathogenesis of Systemic Lupus Erythematosus 81 Clinical Features of Systemic Lupus Erythematosus 82 Treatment of Systemic Lupus Erythematosus 83 Antiphospholipid Syndrome PART 12 Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes 84 Etiology and Pathogenesis of Systemic Sclerosis 85 Clinical Features and Treatment of Scleroderma 86 Inflammatory Diseases of Muscle and Other Myopathies 87 Overlap Syndromes PART 13 Vasculitis 88 Classification and Epidemiology of Systemic Vasculitis 89 Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s Arteritis 90 Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis 91 Polyarteritis Nodosa 92 Immune Complex-Mediated Small Vessel Vasculitis 93 Primary Central Nervous System Vasculitis 94 Behçet’s Disease PART 14 Crystal-Induced and Inflammasome-Mediated Inflammation 95 Pathogenesis of Inflammasome-Mediated Diseases 96 Etiology and Pathogenesis of Hyperuricemia and Gout 97 Clinical Features and Treatment of Gout 98 Calcium Crystal Disease: Calcium Pyrophosphate Deposition Disease and Basic Calcium Phosphate-Associated Syndromes 99 Familial and Nonfamilial Autoinflammatory Syndromes PART 15 Cartilage, Bone, and Heritable Connective Tissue Disorders 100 Etiology and Pathogenesis of Osteoarthritis 101 Clinical Features of Osteoarthritis 102 Treatment of Osteoarthritis 103 Metabolic Bone Disease 104 Proliferative Bone Diseases 105 Osteonecrosis 106 Relapsing Polychondritis 107 Heritable Diseases of Connective Tissues PART 16 Rheumatic Diseases of Childhood 108 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis 109 Clinical Features and Treatment of Juvenile Idiopathic Arthritis 110 Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children, and Neonatal Lupus 111 Juvenile Dermatomyositis, Scleroderma, and Vasculitis PART 17 Infections and Rheumatic Disease 112 Bacterial Arthritis 113 Lyme Disease 114 Mycobacterial Infections of Bones and Joints 115 Fungal Infections of Bones and Joints 116 Rheumatic Manifestations of Human Immunodeficiency Virus Infection 117 Viral Arthritis 118 Rheumatic Fever and Post-streptococcal Arthritis 119 COVID-19 and Rheumatic Disease 120 Vaccination in Rheumatic Disease PART 18 Arthritis Accompanying Systemic Disease 121 Amyloidosis 122 Sarcoidosis 123 Hemochromatosis 124 Hemophilic Arthropathy 125 Rheumatic Manifestations of Hemoglobinopathies 126 IgG4-Related Disease 127 Arthritis Accompanying Endocrine and Metabolic Disorders 128 Rheumatic Paraneoplastic Syndromes and Malignancies With Rheumatic Manifestations 129 Tumors and Tumor-like Lesions of Joints and Related Structures 130 Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer

About the Author :
Gary Firestein, MD, is a board-certified rheumatologist who diagnoses and treats patients with autoimmune conditions as well as diseases of the joints, muscles and bones. A professor at UC San Diego School of Medicine, Dr. Firestein is distinguished for his research and serves as director of the Altman Clinical and Translational Research Institute and the senior associate vice chancellor for health sciences. Dr. Firestein's research interest focuses on the pathogenesis and treatment of rheumatoid arthritis. Dr. Firestein is the recipient of many awards and honors, including the Arthritis Foundation's Jane Wyman Humanitarian Award in 2010 for his contributions to rheumatology; the Arthritis Foundation Lee C. Howley Sr. Prize for Arthritis Research; and the American College of Rheumatology Distinguished Investigator Award. He has been elected to the American Society for Clinical Investigation and the Association of American Physicians. He has served as an editor for the Textbook of Rheumatology for since the 7th edition (2004). Iain McInnes is Director of the Institute of Infection, Immunity and Inflammation at the University of Glasgow, UK. He has extensive experience in leading multicenter programs nationally and internationally. He is Director of the Scottish MRC Clinical Pharmacology and Pathology Clinical PhD Training Program, Chief Investigator for the Scottish Early RA Cohort (SERA) and the related SMS-IC biomarker discovery program (PROMISERA), and chief investigator of numerous global phase II and III clinical trials of novel immune therapies. He has served as member or chair of numerous national grant-funding panels and as chair of several European League Against Rheumatism (EULAR) scientific committees - he is now Treasurer and President Elect of EULAR serving on its Steering Committee. He is formerly Chairman of the Foundation for European Rheumatology Research (Foreum) Scientific Committee and leads the EULAR-supported European Roadmap Program that is defining the research agenda for rheumatology for the next decade. Gary Koretzky, MD, PhD is Professor of Medicine at Weill Cornell Graduate School. Dr. Koretzky's research aims to better understand the signal transduction events that occur following engagement of the T cell antigen receptor. He has been continuously funded by the National Institutes of Health since establishing his independent research group, as the laboratory has expanded its interests to study more globally the molecular events important for immune cell development, differentiation and function. Dr. Koretzky has published more than 200 research articles. He is a past President of the American Society of Clinical Investigation (2000) and Councilor of the Association of American Physicians (2008-2012), is a Fellow of the American Association for the Advancement of Science (2004), a member of the Institute of Medicine of the National Academies (2008), a Fellow of the American Academy of Arts & Sciences (2012) and serves as the Editor-in-Chief of Immunological Reviews (2002-present). Dr. Mikuls is a rheumatologist and epidemiologist with research interests focused on the epidemiology, pathogenesis, and outcomes of rheumatoid arthritis (RA) and gout. He is actively engaged in clinical/translational research activities and has received research funding from the NIH, U.S. Department of Defense, Veterans Affairs, the Rheumatology Research Foundation, and industry. He has extensive experience conducting multi-center / multidisciplinary trials, serving as the Principal Investigator (PI) for the multicenter Veterans Affairs Rheumatoid Arthritis (VARA) registry since its inception in 2003. He has served on multiple national study sections including those convened by the NIH, VA, and the Rheumatology Research Foundation. He previously chaired the American College of Rheumatology (ACR) Subcommittee for Practice Guidelines, served on the US FDA's Arthritis Advisory Committee, and was the Lead Editor for the textbook A Color Handbook - Rheumatology. Tuhina Neogi is a rheumatologist and epidemiologist whose research has focused primarily on risk factors for knee osteoarthritis and gout, pain mechanisms in knee osteoarthritis, as well as methodologic issues of relevance for rheumatic diseases. Dr. Neogi has had continuous peer-reviewed foundation and NIH funding since 2003 and has over 250 peer-reviewed publications to date. She is a past chair of the FDA Arthritis Advisory Committee, serve(d) on the boards of two international societies: Osteoarthritis Research Society International (OARSI) and Gout, Hyperuricemia, and Crystal-Associated Diseases Network (G-CAN), and on committees for the American College of Rheumatology (ACR) and International Association for the Study Pain (IASP), among others. Her work has been recognized with the prestigious 2014 ACR Henry Kunkel Young Investigator Award for outstanding and promising independent contributions to rheumatology research and she has also engaged in developing new classification criteria for a number of rheumatic diseases. James R. O'Dell, MD is the Stokes Shackleford Professor of Internal Medicine, Vice-Chairman of Internal Medicine and Chief of the Division of Rheumatology at the University of Nebraska Medical Center (UNMC) in Omaha. Dr. O'Dell founded and has directed the Rheumatoid Arthritis Investigational Network (RAIN) for the last 25 years. Dr. O'Dell is the PI of the large multinational RA research study based at the VA through their cooperative studies program. Dr. O'Dell has published extensively, mostly in the area of rheumatoid arthritis. He has presented frequently at national and international meetings and has more than 100 published articles in top-level rheumatology journals. He has served on numerous American College of Rheumatology (ACR) committees over the last 20 years, including time on both the ACR and REF BOD, as well as a two-year term as President of the Research and Education Foundation of the ACR and was President of the College (2011-2012). Additionally, he is Editor-in-Chief of Up To Date for Rheumatology.