Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases: 2-Volume Set

**Selected for 2025 Doody’s Core Titles® in Infectious Disease** Offering more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 10th Edition, remains your #1 choice for authoritative, comprehensive information in this challenging field. Meticulously updated by a new editorial team led by Drs. Martin J. Blaser, Jeffrey I. Cohen, and Steven M. Holland, this two-volume masterwork brings together the knowledge and expertise of more than 650 contributing authors who are outstanding scholars and experts in their fields. For ID specialists and general practitioners alike, PPID provides a balanced, detailed perspective for any patient you encounter with a complex or difficult-to-treat infectious disease. Encyclopedic in its depth, contents, and referencing, PPID-10 is the one infectious disease book that needs to be on every practitioner’s shelf and in every medical library. Organizes content both by individual pathogens and by important clinical syndromes, broadening the context to clearly present relevant, complex clinical information. Contains multiple new chapters on both SARS-CoV-2 and anti-fungal therapy, as well as new chapters on bacteriophages and related agents, infections following traumatic injuries, communication to the public about infectious diseases, and the effects of climate change on infectious diseases. Provides up-to-date coverage of recent advances in the field: an increasing understanding of the agents, immune responses, and the growing armamentarium of diagnostics (such as nucleic acid amplification and next-generation sequencing); new treatments (such as monoclonal antibodies, new antifungals, antivirals, and phage therapy); and emerging preventive measures (such as new vaccines being developed for RSV), and our relationship with the human microbiome. Features more than 1,500 high-quality, full-color photographs?with many new to this edition. Shares the extensive experience of new editors Drs. Jeffrey I. Cohen and Steven M. Holland, both from Bethesda, MD, as well as a new team of expert associate editors Drs. Yohei Doi, Wendy S. Garrett, Ann R. Falsey, Eleanor Wilson, Kieren Marr, and Edward Mitre-each a leading authority in their field. Includes perspectives from hundreds of leading experts from a truly global community, including authors from Australia, Canada, and countries in Europe, Asia, and South America. Includes regular updates online for the life of the edition. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date.

Table of Contents:
I Basic Principles in the Diagnosis and Management of Infectious Diseases A Microbial Pathogenesis 1 A Molecular Perspective of Microbial Pathogenicity 2 The Human Microbiome 3 Prebiotics, Probiotics, and Synbiotics B Host Defense Mechanisms 4 Innate (General or Nonspecific) Host Defense Mechanisms 5 Adaptive Immunity: Antibodies and Immunodeficiencies 6 Cell-Mediated Defense Against Infection 7 Mucosal Immunity 8 Granulocytic Phagocytes 9 Complement and Deficiencies 10 Human Genetics and Infection 11 Nutrition, Immunity, and Infection 12 Evaluation of the Patient With Suspected Immunodeficiency C Epidemiology of Infectious Disease 13 Principles of Applied Epidemiology for the Practice of Infectious Diseases 14 Emerging and Reemerging Infectious Disease Threats 15 Bioterrorism: An Overview D Clinical Microbiology 16 The Clinician and the Microbiology Laboratory: Test Ordering, Specimen Collection, and Result Interpretation E Anti-infective Therapy 17 Principles of Anti-infective Therapy 18 Molecular Mechanisms of Antibiotic Resistance in Bacteria 19 Pharmacokinetics and Pharmacodynamics of Anti-infective Agents 20 Penicillins and ?-Lactamase Inhibitors 21 Cephalosporins and Cephalosporin/ ?-Lactamase Inhibitor Combinations 22 Carbapenems, Carbapenem/ ?-Lactamase Inhibitor Combinations, and Aztreonam 23 Antibiotic Allergy 24 Aminoglycosides 25 Tetracyclines, Tetracycline Derivatives, and Chloramphenicol 26 Rifamycins 27 Metronidazole 28 Macrolides and Clindamycin 29 Glycopeptides (Vancomycin and Teicoplanin) and Lipoglycopeptides (Telavancin, Oritavancin, and Dalbavancin) 30 Streptogramins (Quinupristin-Dalfopristin) and Lipopeptides (Daptomycin) 31 Polymyxins (Polymyxin B and Colistin) 32 Linezolid, Tedizolid, and Other Oxazolidinones 33 Sulfonamides and Trimethoprim; Trimethoprim-Sulfamethoxazole 34 Quinolones 35 Antibiotics in Advanced Development and Other Agents 36 Urinary Tract Agents: Nitrofurantoin, Fosfomycin, and Methenamine 37 Topical Antibacterials 38 Antimycobacterial Agents 39 Bacteriophage Therapy, Endolysin Therapy, and Antimicrobial Peptide Therapy 40 Antifungal Agents: Polyene Antifungals 41 Antifungal Drugs: Azole 42 Antifungal Drugs: Echinocandins and Other Beta-d-Glucan Inhibitors 43 Antifungal Drugs: Flucytosine 44 Antimalarial Drugs 45 Drugs for Protozoal Infections Other Than Malaria 46 Drugs for Helminths 47 Antiviral Agents: General Principles 48 Antiviral Drugs for Influenza and Other Respiratory Virus Infections Except for SARS-CoV-2 49 Antivirals Against Herpesviruses 50 Antiviral Drugs Against Hepatitis Viruses 51 Miscellaneous Antiviral Agents (Interferons, Tecovirimat, Imiquimod, Pocapavir) 52 Immunomodulators 53 Hyperbaric Oxygen 54 Antibiotic Stewardship 55 Designing and Interpreting Clinical Studies in Infectious Diseases 56 Outpatient Parenteral Antimicrobial Therapy II Major Clinical Syndromes A Fever 57 Temperature Regulation and the Pathogenesis of Fever 58 Fever of Unknown Origin 59 The Acutely Ill Patient With Fever and Rash B Upper Respiratory Tract Infections 60 The Common Cold 61 Pharyngitis 62 Acute Laryngitis 63 Otitis Externa, Otitis Media, and Mastoiditis 64 Sinusitis 65 Epiglottitis 66 Infections of the Oral Cavity, Neck, and Head C Pleuropulmonary and Bronchial Infections 67 Acute Bronchitis 68 Acute Exacerbations of Chronic Obstructive Pulmonary Disease 69 Acute Pneumonia 70 Pleural Effusion and Empyema 71 Bacterial Lung Abscess 72 Chronic Pneumonia 73 Cystic Fibrosis D Urinary Tract Infections 74 Urinary Tract Infections E Sepsis 75 Sepsis and Septic Shock F Intraabdominal Infections 76 Peritonitis and Intraperitoneal Abscesses 77 Infections of the Liver and Biliary System (Liver Abscess, Cholangitis, Cholecystitis) 78 Pancreatic Infection 79 Splenic Abscess 80 Appendicitis 81 Diverticulitis and Neutropenic Enterocolitis G Cardiovascular Infections 82 Endocarditis and Intravascular Infections 83 Prosthetic Valve Endocarditis 84 Infections of Nonvalvular Cardiovascular Devices 85 Prevention of Infective Endocarditis 86 Myocarditis and Pericarditis 87 Mediastinitis H Central Nervous System Infections 88 Approach to the Patient With Central Nervous System Infection 89 Acute Meningitis 90 Chronic Meningitis 91 Encephalitis 92 Brain Abscess 93 Subdural Empyema, Epidural Abscess, and Suppurative Intracranial Thrombophlebitis 94 Cerebrospinal Fluid Shunt and Drain Infections I Skin and Soft Tissue Infections 95 Cellulitis, Necrotizing Fasciitis, and Subcutaneous Tissue Infections 96 Myositis and Myonecrosis 97 Lymphadenitis and Lymphangitis J Gastrointestinal Infections and Food Poisoning 98 Syndromes of Enteric Infection 99 Esophagitis 100 Diarrhea With Little or No Fever 101 Acute Dysentery Syndromes (Diarrhea With Fever) 102 Typhoid Fever, Paratyphoid Fever, and Typhoidal Fevers 103 Foodborne Disease (Food Poisoning) 104 Tropical Sprue and Environmental Enteric Dysfunction K Bone and Joint Infections 105 Infectious Arthritis of Native Joints 106 Osteomyelitis 107 Orthopedic Implant-Associated Infections L Diseases of the Reproductive Organs and Sexually Transmitted Diseases 108 Anogenital Skin and Mucous Membrane Lesions 109 Urethritis 110 Vulvovaginitis and Cervicitis 111 Infections of the Female Pelvis 112 Prostatitis, Epididymitis, and Orchitis M Eye Infections 113 Introduction to Eye Infections 114 Microbial Conjunctivitis 115 Microbial Keratitis 116 Endophthalmitis 117 Infectious Causes of Uveitis 118 Periocular Infections N Hepatitis 119 Viral Hepatitis O Acquired Immunodeficiency Syndrome 120 Human Immunodeficiency Viruses 121 Global Perspectives on Human Immunodeficiency Virus Infection and AIDS 122 Epidemiology and Prevention of AIDS and HIV Infection, Including Preexposure Prophylaxis and HIV Vaccine Development 123 Diagnosis of Human Immunodeficiency Virus Infection 124 The Immunology of HIV-1 Infection, Mechanisms of Viral Persistence, and Prospects for Cure 125 General Clinical Manifestations of Human Immunodeficiency Virus Infection 126 Pulmonary Manifestations of Human Immunodeficiency Virus Infection 127 Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of Human Immunodeficiency Virus Infection 128 Neurologic Diseases Caused by Human Immunodeficiency Virus Type 1 and Opportunistic Infections 129 Pediatric Human Immunodeficiency Virus Infection 130 Antiretroviral Therapy for Human Immunodeficiency Virus Infection 131 Management of Opportunistic Infections Associated With Human Immunodeficiency Virus Infection P COVID-19 132 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Virology 133 Global Perspective and Epidemiology of COVID-19 134 Immunology and Diagnosis of SARS-CoV-2 and COVID-19 135 Clinical Manifestations of COVID-19 in Adults and Children 136 Treatment and Prevention of SARS-CoV-2 (COVID-19) Q Miscellaneous Syndromes 137 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome III Infectious Diseases and Their Etiologic Agents A Viral Diseases 138 Biology of Viruses and Viral Diseases 139 Orthopoxviruses: Vaccinia (Smallpox Vaccine), Variola (Smallpox), Mpox, and Cowpox 140 Other Poxviruses That Infect Humans: Parapoxviruses (Including Orf Virus), Molluscum Contagiosum, and Yatapoxviruses 141 Introduction to Herpesviridae 142 Herpes Simplex Virus 143 Chickenpox and Herpes Zoster (Varicella-Zoster Virus) 144 Cytomegalovirus 145 Epstein-Barr Virus (Infectious Mononucleosis, EBV-Associated Malignant Diseases, and Other Diseases) 146 Human Herpesvirus Types 6 and 7 (Exanthem Subitum) 147 Kaposi Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) 148 Herpes B Virus 149 Adenoviruses 150 Papillomaviruses 151 JC, BK, and Other Polyomaviruses: Progressive Multifocal Leukoencephalopathy, BK Nephropathy, and Merkel Cell Carcinoma 152 Hepatitis B Virus 153 Hepatitis D Virus 154 Human Parvoviruses, Including Parvovirus B19, Human Bocaviruses, and Adeno-Associated Viruses (AAVs) 155 Orthoreoviruses and Orbiviruses 156 Coltiviruses (Colorado Tick Fever Virus) and Seadornaviruses 157 Rotaviruses 158 Alphaviruses 159 Rubella Virus (German Measles) 160 Flaviviruses 161 Hepatitis C 162 Coronaviruses, Including SARS and MERS 163 Parainfluenza Viruses 164 Mumps Virus 165 Respiratory Syncytial Virus 166 Human Metapneumovirus 167 Measles Virus (Rubeola) 168 Zoonotic Paramyxoviruses: Nipah, Hendra, and Pararubulaviruses 169 Vesicular Stomatitis Virus and Related Vesiculoviruses (Chandipura Virus) 170 Rabies (Rhabdoviruses) 171 Marburg and Ebola Virus Diseases 172 Influenza Viruses, Including Avian and Swine Influenza 173 Bunyavirus Infections: Hantavirus Syndromes, La Crosse Encephalitis, Rift Valley Fever, Crimean-Congo Hemorrhagic Fever, and Others 174 Lymphocytic Choriomeningitis Virus, Lassa Virus, Lujo Virus, and Other Hemorrhagic Fever Viruses (Arenaviruses) 175 Human T-Lymphotropic Virus 176 Introduction to Human Enteroviruses and Parechoviruses 177 Poliovirus 178 Coxsackieviruses, Echoviruses, and Other Enteroviruses (EV-D68, EV-D70, EV-A71) 179 The Human Parechoviruses 180 Hepatitis A Virus 181 Rhinovirus 182 Noroviruses and Sapoviruses (Caliciviruses) 183 Astroviruses and Picobirnaviruses 184 Hepatitis E Virus B Prion Diseases 185 Prions and Prion Diseases of the CNS (Transmissible Neurodegenerative Diseases) C Chlamydial Diseases 186 Chlamydia trachomatis 187 Psittacosis (Due to Chlamydia psittaci) 188 Chlamydia pneumoniae D Mycoplasma Diseases 189 Mycoplasmoides (Mycoplasma) pneumoniae 190 Genital Mycoplasmas (Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma Species) E Rickettsioses, Ehrlichioses, and Anaplasmoses 191 Introduction to Rickettsioses, Ehrlichioses, and Anaplasmoses 192 Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae 193 Coxiella burnetii (Q Fever) 194 Rickettsia prowazekii (Epidemic Typhus) 195 Rickettsia typhi (Murine Typhus) 196 Orientia tsutsugamushi (Scrub TYphus) 197 Ehrlichia chaffeensis, Anaplasma phagocytophilum, and Other Anaplasmataceae F Bacterial Diseases 198 Introduction to Bacteria and Bacterial Diseases i. Infections Due to Gram-Positive Bacteria 199 Staphylococcus aureus 200 Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci 201 Classification of Streptococci 202 Streptococcus pyogenes (Group A Streptococcus) 203 Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis 204 Streptococcus pneumoniae 205 Enterococcus Species, Streptococcus gallolyticus Group, and Leuconostoc Species 206 Streptococcus agalactiae (Group B Streptococci) 207 Viridans Streptococci, Nutritionally Variant Streptococci, and Groups C and G Streptococci 208 Streptococcus anginosus Group 209 Corynebacterium diphtheriae (Diphtheria) 210 Other Coryneform Bacteria and Rhodococci 211 Listeria monocytogenes 212 Bacillus anthracis (Anthrax) 213 Bacillus Species and Related Genera Other Than Bacillus anthracis 214 Erysipelothrix rhusiopathiae 215 Whipple Disease ii. Infections Due to Gram-Negative Bacteria 216 Neisseria meningitidis 217 Neisseria gonorrhoeae (Gonorrhea) 218 Moraxella catarrhalis, Kingella, and Other Gram-Negative Cocci 219 Vibrio cholerae 220 Other Pathogenic Vibrios 221 Campylobacter jejuni and Related Species 222 Helicobacter pylori and Other Gastric Helicobacter Species 223 Enterobacterales (Enterobacteriaceae) 224 Pseudomonas aeruginosa and Other Pseudomonas Species 225 Stenotrophomonas maltophilia and Burkholderia cepacia Complex 226 Burkholderia pseudomallei and Burkholderia mallei (Melioidosis, Glanders) 227 Acinetobacter Species 228 Salmonella Species 229 Bacillary Dysentery: Shigella and Enteroinvasive Escherichia coli 230 Haemophilus Species, Including H. influenzae and H. ducreyi (Chancroid) 231 Brucellosis (Brucella Species) 232 Francisella tularensis (Tularemia) 233 Pasteurella Species 234 Plague (Yersinia pestis) 235 Yersinia enterocolitica and Yersinia pseudotuberculosis 236 Bordetella pertussis 237 Rat-Bite Fever: Streptobacillus moniliformis and Spirillum minus 238 Legionnaires’ Disease and Pontiac Fever 239 Capnocytophaga Species 240 Bartonella, Including Cat-Scratch Disease 241 Klebsiella granulomatis (Donovanosis, Granuloma Inguinale) 242 Other Gram-Negative and Gram-Variable Bacilli iii. Infections Due to Spirochetal Bacteria 243 Syphilis (Treponema pallidum) 244 Endemic Treponematoses 245 Leptospira Species (Leptospirosis) 246 Relapsing Fever Caused by Borrelia Species 247 Lyme Disease (Lyme Borreliosis) Due to Borrelia burgdorferi iv. Infections Due to Anaerobic Bacteria 248 Anaerobic Infections: General Concepts 249 Clostridioides (Clostridium) difficile Infection 250 Tetanus (Clostridium tetani) 251 Botulism (Clostridium botulinum) 252 Diseases Caused by Clostridium 253 Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species (and Other Medically Important Anaerobic Gram-Negative Bacilli) 254 Anaerobic Cocci and Anaerobic Gram-Positive Nonsporulating Bacilli v. Infections Due to Acid-Fast Organisms 255 Mycobacterium tuberculosis 256 Leprosy (Mycobacterium leprae) 257 Mycobacterium avium Complex 258 Infections Caused by Nontuberculous Mycobacteria Other Than Mycobacterium avium Complex 259 Nocardia Species 260 Agents of Actinomycosis G Mycoses 261 Introduction to Mycoses 262 Candida Species 263 Aspergillus Species 264 Agents of Mucormycosis and Entomophthoramycosis 265 Sporothrix schenckii 266 Chromoblastomycosis 267 Mycetoma 268 Cryptococcosis (Cryptococcus neoformans and Cryptococcus gattii) 269 Histoplasma capsulatum (Histoplasmosis) 270 Blastomyces 271 Coccidioides Species 272 Dermatophytosis (Ringworm) and Other Superficial Mycoses 273 Paracoccidioides 274 Uncommon Fungi and Related Species 275 Pneumocystis Species 276 Microsporidiosis H Protozoal Diseases 277 Introduction to Protozoal Diseases 278 Entamoeba Species, Including Amebic Colitis and Liver Abscess 279 Free-Living Amebae 280 Malaria (Plasmodium Species) 281 Leishmania Species: Visceral, Cutaneous, and Mucosal Leishmaniasis 282 Trypanosoma Species (American Trypanosomiasis, Chagas Disease) 283 Agents of African Trypanosomiasis (Sleeping Sickness) 284 Toxoplasma gondii 285 Giardia lamblia 286 Trichomonas vaginalis 287 Babesia Species 288 Cryptosporidiosis (Cryptosporidium Species) 289 Cyclospora cayetanensis, Cystoisospora belli, Sarcocystis Species, Balantidium coli, and Blastocystis Species I Diseases Due to Toxic Algae 290 Human Illness Associated With Cyanobacteria and Harmful Algal Blooms, Including Fish and Shellfish Poisoning Syndromes J Diseases Due to Helminths 291 Introduction to Helminth Infections 292 Intestinal Nematodes (Roundworms) 293 Tissue Nematodes, Including Trichinellosis, Dracunculiasis, and the Filariases 294 Trematodes (Schistosomes and Liver, Intestinal, and Lung Flukes) 295 Tapeworms (Cestodes) 296 Visceral Larva Migrans and Other Uncommon Helminth Infections K Ectoparasitic Diseases 297 Introduction to Ectoparasitic Diseases 298 Lice (Pediculosis) 299 Scabies 300 Myiasis and Tungiasis 301 Mites, Including Chiggers 302 Ticks, Including Tick Paralysis L Diseases of Unknown Etiology 303 Kawasaki Disease IV. Special Problems A Nosocomial Infections 304 Infection Prevention and Control in Healthcare 305 Disinfection, Sterilization, and Hospital Waste 306 Infections Caused by Percutaneous Intravascular Devices 307 Nosocomial Pneumonia 308 Catheter-Associated Urinary Tract Infection (CAUTI) and CA-AB 309 Transfusion- and Transplant-Transmitted Infections B Infections in Special Hosts 310 Infections in the Immunocompromised Host: Principles 311 Prophylaxis and Empirical Therapy in Cancer Patients 312 Infections in Hematopoietic Cell Transplantation 313 Infections in Solid Organ Transplant Recipients 314 Infections in Older Adults 315 Infections in Asplenic Patients 316 Infections in Persons Who Inject Drugs C Surgical- and Trauma-Related Infections 317 Surgical Site Infections and Prophylaxis 318 Burns 319 Infections Following Trauma 320 Bites D Immunization 321 Principles of Immunization for Public Health 322 Immunizations for Specific Infections 323 Protection of Travelers 324 Infections in Returning Travelers E Emerging Issues in Infectious Diseases 325 Zoonoses 326 Communicating About Infectious Diseases to the Public 327 Basic Principles in Climate Change and Infectious Diseases

About the Author :
Martin J. Blaser is the Henry Rutgers Chair of the Human Microbiome at Rutgers University, where he also holds professorships in Medicine and Pathology & Laboratory Medicine, and directs the Center for Advanced Biotechnology and Medicine. Prior to this, he was Chair of the Department of Medicine at New York University. As both a physician and microbiologist, Dr. Blaser has dedicated over three decades to exploring the complex relationships between humans and their long-term bacterial colonizers. His research initially centered on Campylobacter species and Helicobacter pylori, which serve as key models for studying host-microbe interactions. In the past 20 years, his focus has expanded to investigating how the human microbiome influences health and contributes to diseases such as asthma, allergies, obesity, diabetes, neurological disorders, and cancer. Dr. Blaser has mentored numerous students, postdoctoral fellows, and junior faculty members throughout his career. He holds 28 U.S. patents and has published more than 600 original scientific articles. Additionally, he is the author of the widely acclaimed book Missing Microbes, aimed at general readers and translated into 20 languages.