About the Book
Vaccinology and Methods in Vaccine Research is a combination of cutting-edge methodologies, experimental approaches and literature reviews. The book covers all aspects of vaccine development, including basic immunology (focusing on the stimulation of adaptive immunity, which is required for vaccine efficacy), approaches to vaccine design and target validation, vaccine biomanufacturer and clinical development. Existing vaccinology resources are theoretical reference books, whereas this book provides a practical handbook for use in the research lab and classroom by those working in vaccinology and training others in the field.
It is authored and edited by scientists actively engaged in vaccine research and development for day-to-day teaching/methodological advice.
Table of Contents:
1. Immunology and the Concept of Vaccination
Rebecca Chukwuanukwu, A. Ehiaghe, A. Rowaiye and Angus Nnamdi Oli
2. Vaccine Types and Reverse Vaccinology
A. Rowaiye and Angus Nnamdi Oli
3. Dendritic Cells as Vaccine Targets
P. Aondona, F. Iseghohi, A. Rowaiye and Angus Nnamdi Oli
4. Vaccine Development: From the Laboratory to the Field
Nana Efua Andoh and Linda Onyeka Anagu
5. Immunopeptidomics for the Identification of T cell Vaccine Targets
P. Bettencourt and C. Barbosa
6. Virus Like Particle Vaccines
Ahmed M. Salman, Ekta Mukhopadhyay and Adrian Hill
7. Approaches to Cancer Vaccination
Ezinne Janefrances Nwonu
8. Vaccines against SARS-CoV-2
K. Ewer and Andrés Noé
9. Adjuvants, Immunomodulators and Adaptogens
Anita Milicic, M. Ugwu, Sabina Górska, Agnieszka Razim, M. Luchner, Slavcho Mrenoshki, H. Kefei, G. Corby, A. Thakur, Sveinbjorn Gizurarson, J. Fergusson, Dennis Christensen, S. Ercelen, S. Longet, B. Morein, E. Lindblad and S. Reinke
10. GMP Manufacture and Quality Control Chapter
Rebecca Ashfield
11. Testing Vaccines: Essential Steps in Clinical Trial Design
Julia Marshall
About the Author :
Rebecca Ashfield Jenner Institute, University of Oxford (ORCRB Roosevelt Drive Oxford OX3 7DQ). BA (1st class) Oxford, DPhil Oxford, over 20 years working in field of immunotherapy and vaccine development. Currently CSO of Ducentis Biotherapeutics Ltd and Senior Project Manager at the Jenner Institute. Organiser/co-leader of several vaccinology courses in Oxford and Leiden. Edited most recent Jenner Institute triennial report. Expertise in vaccine GMP manufacture, led successful application to Innovate UK for £75M vaccine innovation and manufacturing centre, currently being built at Harwell in Oxfordshire. H=20 Angus Nnamdi Oli Pharmaceutical Microbiology and Biotechnology, Nnamdi Azikiwe University (NAU), Agulu Campus (Post code 422001, Agulu, Anambra State, Nigeria). BPharm. and MPharm. UNN, DPhil NAU and a DPharm. University of Benin, Nigeria. Currently a Senior Lecturer with over 8 years’ experience. Author of several articles in peer-reviewed journals indexed in Pubmed, Web of Science and Scopus. Current research interests/career goals are Infection and immunology of infectious diseases with emphasis of viral and bacterial infections, development of effective vaccines with strong antibody and T lymphocytes effect or responses against the infections, Pharmaceutical Quality Systems and Clinical vaccinology. H: 5 Charles Okechukwu Esimone Pharmaceutical Microbiology and Biotechnology, Nnamdi Azikiwe University (NAU, Main Campus, PMB 5025, Awka, Anambra State, Nigeria). BPharm., MPharm. and PhD in Pharmaceutics, University of Nigeria, Nsukka (UNN). With over 20 years’ experience as a lecturer and research scientist and over 12 years’ experience in vaccinology/immunology research. Currently a Professor and VC of Nnamdi Azikiwe University, Editor-in-Chief of the Journal of Current Biomedical Research and the Biomedical Research Committee, currently chaired by me, focuses on the development of biotechnological products such as vaccines for tropical diseases, amongst other interest. H: 18 Linda Onyeka Anagu Pharmaceutical Microbiology and Biotechnology, Nnamdi Azikiwe University (NAU), Agulu Campus (Post code 422001, Agulu, Anambra State, Nigeria). BPharm. and MPharm. UNN, DPhil Keele University. With over 8 years’ experience as a lecturer and research scientist. She has interest in vaccine design/development processes that borders on her expertise in molecular cloning and Plasmodium epigenetics. Recently, attended the Vaccinology Summer School organized by Dr. Rebecca Ashfield and the late Dr. Sahid Khan in Leiden. Edited the recent, 2015 edition of LABORATORY HANDBOOK OF PHARMACEUTICAL MICROBIOLOGY AND BIOTECHNOLOGY, used by undergraduate and postgraduate students at Nnamdi Azikiwe University. ERC H: 5
