Middleton's Allergy 2-Volume Set: Principles and Practice (Expert Consult Premium Edition - Enhanced Online Features and Print)

Boasting a worldwide reputation as the leading text in allergy and immunology, Middleton's Allergy continues its steadfast tradition of providing comprehensive coverage of state-of-the-art basic science, as well as authoritative guidance on the clinical concepts of day-to-day diagnosis and management of allergic disorders. Offering timely information that’s suited for clinicians and researchers alike, Middleton’s is a user-friendly and versatile source for the knowledge you need to provide optimal care to your patients! "A valuable source of reference and pre-sifted information ...the editors are to be commending in keeping the book up-to-date and clinically valuable." Reviewed by: Imnunology News, March 2015 Stay on top of continuous new developments in clinical allergy and immunology through online access to the Expert Consult site, which will feature regular updates as well as the fully searchable contents. Find all of the information you need quickly and easily with a glossary of allergy and immunology terms; highlighted key points for each chapter; hundreds of crystal-clear images with a full-color format, and access to relevant websites. Apply the latest scientific knowledge and clinical applications with new chapters on Innate and Adaptive Immunity, Immune Tolerance, Immunobiology of IgE and Its Receptors, Resolution of Allergic Inflammation, and Particulate and Allergen Interactions, plus sweeping updates throughout. Take full advantage of the major advances in asthma pathogenesis and management with significant updates on diagnosis, treatment, and special aspects of asthma. Obtain the best results from the newest therapeutics for allergic and immunologic diseases through an expanded discussion of immunotherapy that includes new chapters on Sublingual Immunotherapy, Biologics and Immunosuppressives in Asthma, and Alternative and Complementary Therapies.

Table of Contents:
Volume 1 SECTION A Basic Sciences Underlying Allergy and Immunology 1 Innate Immunity 2 Adaptive Immunity 3 Immunoglobulin Structure and Function 4 Immune Tolerance 5 Cytokines in Allergic Inflammation 6 Cellular Adhesion in Inflammation 7 Chemokines 8 The Complement System 9 Lipid Mediators of Hypersensitivity and Inflammation 10 Molecular Biology and Genetic Engineering 11 Signal Transduction 12 Biology of Lymphocytes 13 Antigen-Presenting Dendritic Cells 14 Biology of Mast Cells and Their Mediators 15 Biology of Basophils 16 Biology of Eosinophils 17 Biology of Neutrophils 18 Biology of Monocytes and Macrophages 19 Airway Epithelial Cells 20 Noncontractile Functions of Airway Smooth Muscle 21 Pathophysiology of Allergic Inflammation 22 Genetics and Epigenetics in Allergic Diseases and Asthma 23 Immunobiology of IgE and IgE Receptors 24 Neuronal Control of Airway Function in Allergy 25 Resolution of Allergic Inflammation SECTION B Aerobiology and Allergens 26 The Structure and Function of Allergens 27 Aerobiology of Outdoor Allergens 28 Indoor Allergens 29 Preparation and Standardization of Allergen Extracts 30 Air Pollution: Indoor and Outdoor 31 Particulate and Pollen Interactions 32 Effect of the Food Matrix and Processing on the Allergenic Activity of Foods SECTION C The Skin 33 Structure of the Skin and Cutaneous Immunology 34 Atopic Dermatitis 35 Contact Dermatitis 36 Urticaria and Angioedema 37 Hereditary Angioedema and Bradykinin- Mediated Angioedema 38 Immune Complex-Mediated Diseases SECTION D The Eye 39 Allergic and Immunologic Diseases of the Eye SECTION E Respiratory Tract 40 The Nose and Control of Nasal Airflow 41 Nasal Provocation Testing 42 Allergic and Nonallergic Rhinitis 43 Rhinosinusitis and Nasal Polyps 44 Development, Structure, and Physiology in Normal Lung and in Asthma 45 Respiratory Tract Mucosal Immunology 46 Airway Smooth Muscle Function in Asthma: Extracellular Matrix and Airway Remodeling 47 Airway Mucus and the Mucociliary System 48 Epidemiology of Asthma and Allergic Airway Diseases 49 Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma 50 Asthma Pathogenesis 51 Mouse Models of Allergic Airways Disease 52 Diagnosis of Asthma in Infants and Children 53 Management of Asthma in Infants and Children 54 Diagnosis of Asthma in Adults 55 Management of Asthma in Adolescents and Adults 56 Emergency Treatment and Approach to the Patient with Acute Asthma 57 Approach to the Patient with Exercise- Induced Bronchoconstriction 58 Asthma and Allergic Diseases during Pregnancy 59 Occupational Allergy and Asthma 60 Pathology of Asthma 61 Allergic Bronchopulmonary Aspergillosis and Hypersensitivity Pneumonitis 62 Immunologic Nonasthmatic Diseases of the Lung 63 Approach to the Patient with Chronic Cough 64 Bronchial Challenge Testing 65 Lung Imaging 66 Aerosols and Aerosol Drug Delivery Systems Volume 2 SECTION F Gastrointestinal Tract 67 Gastrointestinal Mucosal Immunology 68 Eosinophilic Gastrointestinal Disorders SECTION G Systemic Disease 69 Clinical Significance of Immunoglobulin E 70 In Vivo Methods for the Study and Diagnosis of Allergy 71 Approach to the Patient with Recurrent Infections 72 Primary Immunodeficiency Diseases 73 Human Immunodeficiency Virus and Allergic Disease 74 Laboratory Tests for Allergic and Immunodeficiency Diseases 75 Eosinophilia and Eosinophil-Related Disorders 76 Mastocytosis 77 Anaphylaxis 78 Insect Allergy 79 Drug Allergy 80 Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs 81 Reactions to Foods 82 Reactions to Food and Drug Additives 83 Oral Food Challenge Testing 84 Food Allergy Management 85 Adverse Reactions to Vaccines for Infectious Diseases SECTION H Therapeutics 86 Allergen Control for Prevention and Management of Allergic Diseases 87 Injection Immunotherapy for Inhalant Allergens 88 Sublingual Immunotherapy for Inhalant Allergens 89 Principles of Pharmacotherapeutics 90 Pharmacogenomics of Asthma Therapies 91 Adherence 92 Anti-Immunoglobulin E Therapy 93 Cytokine-Specific Therapy in Asthma 94 Histamine and H1 Antihistamines 95 Inhaled ß2-Agonists 96 Theophylline and Phosphodiesterase Inhibitors 97 Anticholinergic Therapies 98 The Chromones: Cromolyn Sodium and Nedocromil Sodium 99 Glucocorticosteroids 100 Antileukotriene Therapy in Asthma 101 Unconventional Theories and Unproven Methods in Allergy 102 Complementary and Alternative Medicine Appendixes APPENDIX A CD Molecules APPENDIX B Internet Resources for Allergy and Immunology Professionals

Review :
"The chapter on anaphylaxis is an excellent summary, particularly Box 77-7 covering the differential diagnosis. As usual, the chapter on unconventional theories is a masterpiece of debunking nonsense allergy, with a robust approach to looking for supportive scientific studies. This is a must-read chapter for all practicing allergists. Equally the following chapter on complementary and alternative medicine gives a useful summary of philosophies of the main complementary therapies." Reviewed by Imnunology News, Mar 2015