Genetic Analysis
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Genetic Analysis: An Integrated Approach

Genetic Analysis: An Integrated Approach


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&>ALERT: Before you purchase, check with your instructor or review your course syllabus to ensure that you select the correct ISBN. Several versions of Pearson's MyLab & Mastering products exist for each title, including customized versions for individual schools, and registrations are not transferable. In addition, you may need a CourseID, provided by your instructor, to register for and use Pearson's MyLab & Mastering products.   Packages Access codes for Pearson's MyLab & Mastering products may not be included when purchasing or renting from companies other than Pearson; check with the seller before completing your purchase.   Used or rental books If you rent or purchase a used book with an access code, the access code may have been redeemed previously and you may have to purchase a new access code.   Access codes Access codes that are purchased from sellers other than Pearson carry a higher risk of being either the wrong ISBN or a previously redeemed code. Check with the seller prior to purchase.   Informed by many years of genetics teaching and research expertise, authors Mark Sanders and John Bowman use an integrated approach that helps contextualize three core challenges of learning genetics: solving problems, understanding evolution, and understanding the connection between traditional genetics models and more modern approaches.   Genetic Analysis: An Integrated Approach, 2/e is extensively updated with relevant, cutting-edge coverage of modern genetics and is supported by MasteringGenetics, the most widely-used homework and assessment program in genetics. Featuring expanded assignment options, MasteringGenetics complements the book’s problem-solving approach, engages students, and improves results by helping them master concepts and problem-solving skills.

Table of Contents:
BRIEF CONTENTS 1 The Molecular Basis of Heredity, Variation, and Evolution   1.1 Modern Genetics Is in Its Second Century   1.2 The Structure of DNA Suggests a Mechanism for Replication   1.3 DNA Transcription and Messenger RNA Translation Express Genes   1.4 Evolution Has a Molecular Basis   Case Study The Modern Human Family Mystery   Summary • Keywords  • Problems   2 Transmission Genetics   2.1 Gregor Mendel Discovered the Basic Principles of Genetic Transmission 2.2 Monohybrid Crosses Reveal the Segregation of Alleles   2.3 Dihybrid and Trihybrid Crosses Reveal the Independent Assortment of    Alleles   2.4 Probability Theory Predicts Mendelian Ratios   2.5 Chi-Square Analysis Tests the Fit between Observed Values and    Expected Outcomes   2.6 Autosomal Inheritance and Molecular Genetics Parallel the Predictions    of Mendel’s Hereditary Principles   Case Study Inheritance of Sickle Cell Disease in Humans   Summary  • Keywords   • Problems   3 Cell Division and Chromosome Heredity   3.1 Mitosis Divides Somatic Cells   3.2 Meiosis Produces Gametes for Sexual Reproduction   3.3 The Chromosome Theory of Heredity Proposes That Genes Are    Carried on Chromosomes   3.4 Sex Determination Is Chromosomal and Genetic   3.5 Human Sex-Linked Transmission Follows Distinct Patterns   3.6 Dosage Compensation Equalizes the Expression of Sex-Linked        Genes   Case Study The (Degenerative) Evolution of the Mammalian Y Chromosome   Summary  • Keywords  • Problems   4 Inheritance Patterns of Single Genes and Gene Interaction   4.1 Interactions between Alleles Produce Dominance Relationships   4.2 Some Genes Produce Variable Phenotypes   4.3 Gene Interaction Modifies Mendelian Ratios   4.4 Complementation Analysis Distinguishes Mutations in the Same Gene    from Mutations in Different Genes   Case Study  Complementation Groups in a Human Cancer-Prone Disorder   Summary  • Keywords • Problems   5 Genetic Linkage and Mapping in Eukaryotes   5.1 Linked Genes Do Not Assort Independently   5.2 Genetic Linkage Mapping Is Based on Recombination Frequency    between Genes   5.3 Three-Point Test-Cross Analysis Maps Genes   5.4 Recombination Results from Crossing Over   5.5 Linked Human Genes Are Mapped Using Lod Score Analysis   5.6 Recombination Affects Evolution and Genetic Diversity   5.7 Genetic Linkage in Haploid Eukaryotes Is Identified by Tetrad Analysis     5.8 Mitotic Crossover Produces Distinctive Phenotypes Case Study Mapping the Gene for Cystic Fibrosis   Summary  • Keywords  • Problems   6 Genetic Analysis and Mapping in Bacteria and Bacteriophages   6.1 Bacteria Transfer Genes by Conjugation   6.2 Interrupted Mating Analysis Produces Time-of-Entry Maps   6.3 Conjugation with F¢ Strains Produces Partial Diploids   6.4 Bacterial Transformation Produces Genetic Recombination   6.5 Bacterial Transduction Is Mediated by Bacteriophages   6.6 Bacteriophage Chromosomes Are Mapped by Fine-Structure Analysis   6.7 Lateral Gene Transfer Alters Genomes Case Study The Evolution of Antibiotic Resistance and Change in Medical Practice   Summary   • Keywords   • Problems  7 DNA Structure and Replication   7.1 DNA Is the Hereditary Molecule of Life   7.2 The DNA Double Helix Consists of Two Complementary and    Antiparallel Strands   7.3 DNA Replication Is Semiconservative and Bidirectional   7.4 DNA Replication Precisely Duplicates the Genetic Material   7.5 Molecular Genetic Analytical Methods Make Use of DNA Replication    Processes   Case Study Use of PCR and DNA Sequencing to Analyze Huntington Disease Mutations   Summary  • Keywords  • Problems   8 Molecular Biology of Transcription and RNA Processing  8.1 RNA Transcripts Carry the Messages of Genes   8.2 Bacterial Transcription Is a Four-Stage Process  8.3 Archaeal and Eukaryotic Transcription Displays Structural Homology and Common Ancestry   8.4 Post-Transcriptional Processing Modifies RNA Molecules   Case Study Sexy Splicing: Alternative mRNA Splicing and Sex Determination in Drosophila   Summary  • Keywords   • Problems   9 The Molecular Biology of Translation   9.1 Polypeptides Are Composed of Amino Acid Chains That Are Assembled at Ribosomes   9.2 Translation Occurs in Three Phases   9.3 Translation Is Fast and Efficient   9.4 The Genetic Code Translates Messenger RNA into Polypeptide  9.5 Experiments Deciphered the Genetic Code   9.6   Translation Is Followed by Polypeptide Folding, Processing, and Protein Sorting   Case Study Antibiotics and Translation Interference   Summary  • Keywords  • Problems   10   The Integration of Genetic Approaches: Understanding Sickle Cell    Disease  10.1   An Inherited Hemoglobin Variant Causes Sickle Cell Disease   10.2   Genetic Variation Can Be Detected by Examining DNA, RNA, and    Proteins   10.3   Sickle Cell Disease Evolved by Natural Selection in Human Populations   Case Study Transmission and Molecular Genetic Analysis of Thalassemia   Summary   • Keywords • Problems   11   Chromosome Structure   11.1   Viruses Are Infectious Particles Containing Nucleic Acid Genomes   11.2   Bacterial Chromosomes Are Organized by Proteins   11.3   Eukaryotic Chromosomes Are Organized into Chromatin   11.4   Chromatin Compaction Varies along the Chromosome  11.5   Chromatin Organizes Archaeal Chromosomes   Case Study Fishing for Chromosome Abnormalities in Cancer Cells   Summary  • Keywords • Problems   12   Gene Mutation, DNA Repair, and Homologous Recombination   12.1   Mutations Are Rare and Occur at Random   12.2   Gene Mutations Modify DNA Sequence   12.3   Gene Mutations May Arise from Spontaneous Events   12.4   Mutations May Be Induced by Chemicals or Ionizing Radiation   12.5   Repair Systems Correct Some DNA Damage   12.6   Proteins Control Translesion DNA Synthesis and the Repair of    Double-Strand Breaks   12.7   DNA Double-Strand Breaks Initiate Homologous Recombination   12.8   Gene Conversion Is Directed Mismatch Repair in Heteroduplex    DNA   Case Study Li-Fraumeni Syndrome Is Caused by Inheritance of Mutations of p53   Summary • Keywords • Problems   13   Chromosome Aberrations and Transposition   13.1   Nondisjunction Leads to Changes in Chromosome Number   13.2   Changes in Euploidy Result in Various Kinds of Polyploidy   13.3   Chromosome Breakage Causes Mutation by Loss, Gain, and    Rearrangement of Chromosomes   13.4   Chromosome Breakage Leads to Inversion and Translocation of    Chromosomes   13.5   Transposable Genetic Elements Move throughout the Genome  13.6   Transposition Modifies Bacterial Genomes   13.7   Transposition Modifies Eukaryotic Genomes   Case Study Human Chromosome Evolution   Summary • Keywords • Problems   14   Regulation of Gene Expression in Bacteria and Bacteriophage   14.1   Transcriptional Control of Gene Expression Requires DNA—Protein    Interaction   14.2   The lac Operon Is an Inducible Operon System under Negative and    Positive Control   14.3   Mutational Analysis Deciphers Genetic Regulation of the lac Operon   14.4   Transcription from the Tryptophan Operon Is Repressible and    Attenuated   14.5   Bacteria Regulate the Transcription of Stress Response Genes and Translation and Archaea Regulate Transcription in a      Bacteria-like Manner       14.6   Antiterminators and Repressors Control Lambda Phage Infection of    E. coli   Case Study Vibrio cholerae–Stress Response Leads to Serious Infection   Summary • Keywords  • Problems   15   Regulation of Gene Expression in Eukaryotes   15.1   Cis-Acting Regulatory Sequences Bind Trans-Acting Regulatory    Proteins to Control Eukaryotic Transcription        Transcriptional Regulatory Interactions   15.2   Chromatin Remodeling and Modification Regulates Eukaryotic Transcription   15.3   RNA-Mediated Mechanisms Control Gene Expression   Case Study Environmental Epigenetics   Summary • Keywords  • Problems  16   Analysis of Gene Function via Forward Genetics and Reverse Genetics   16.1   Forward Genetic Screens Identify Genes by Their Mutant Phenotypes   16.2   Genes Identified by Mutant Phenotype Are Cloned Using Recombinant DNA Technology   16.3   Reverse Genetics Investigates Gene Action by Progressing from Gene Identification to Phenotype  16.4   Transgenes Provide a Means of Dissecting Gene Function    Case Study  Reverse Genetics and Genetic Redundancy in Flower Development   Summary • Keywords • Problems   17   Recombinant DNA Technology and Its Applications   17.1   Specific DNA Sequences Are Identified and Manipulated Using Recombinant DNA Technology   17.2   Introducing Foreign Genes into Genomes Creates Transgenic Organisms 17.3   Gene Therapy Uses Recombinant DNA Technology 17.4   Cloning of Plants and Animals Produces Genetically Identical    Individuals   Case Study Curing Sickle Cell Disease in Mice  Summary • Keywords  • Problems  18   Genomics: Genetics from a Whole-Genome Perspective   18.1   Structural Genomics Provides a Catalog of Genes in a Genome   18.2 Annotation Ascribes Biological Function to DNA Sequences   18.3   Evolutionary Genomics Traces the History of Genomes   18.4   Functional Genomics Aids in Elucidating Gene Function   Case Study Genomic Analysis of Insect Guts May Fuel the World   Summary  • Keywords • Problems   19   Organelle Inheritance and the Evolution of Organelle Genomes   19.1   Organelle Inheritance Transmits Genes Carried on Organelle Chromosomes   19.2   Modes of Organelle Inheritance Depend on the Organism   19.3   Mitochondria Are the Energy Factories of Eukaryotic Cells   19.4   Chloroplasts Are the Sites of Photosynthesis   19.5   The Endosymbiosis Theory Explains Mitochondrial and Chloroplast    Evolution   Case Study Ototoxic Deafness: A Mitochondrial Gene—Environment Interaction   Summary  • Keywords  • Problems   20   Developmental Genetics   20.1   Development Is the Building of a Multicellular Organism   20.2   Drosophila Development Is a Paradigm for Animal Development  20.3   Cellular Interactions Specify Cell Fate   20.4   “Evolution Behaves Like a Tinkerer”   20.5   Plants Represent an Independent Experiment in Multicellular Evolution   Case Study Cyclopia and Polydactyly–Different Shh Mutations with Distinctive Phenotypes   Summary • Keywords • Problems   21   Genetic Analysis of Quantitative Traits   21.1   Quantitative Traits Display Continuous Phenotype Variation  21.2   Quantitative Trait Analysis Is Statistical   21.3   Heritability Measures the Genetic Component of Phenotypic Variation   21.4   Quantitative Trait Loci Are the Genes That Contribute to Quantitative    Traits  Case Study  GWAS and Crohn’s Disease    Summary • Keywords • Problems   22   Population Genetics and Evolution at the Population, Species, and Molecular Levels   22.1   The Hardy—Weinberg Equilibrium Describes the Relationship of Allele    and Genotype Frequencies in Populations  22.2   Natural Selection Operates through Differential Reproductive Fitness    within a Population   22.3   Mutation Diversifies Gene Pools   22.4   Migration Is Movement of Organisms and Genes between    Populations   22.5   Genetic Drift Causes Allele Frequency Change by Sampling Error   22.6   Inbreeding Alters Genotype Frequencies  22.7   Species and Higher Taxonomic Groups Evolve by the Interplay of Four    Evolutionary Processes   22.8   Molecular Evolution Changes Genes and Genomes through Time Case Study CODIS–Using Population Genetics to Solve Crime and Identify Paternity   Summary  • Keywords • Problems        Selected References and Readings      Answers to Selected Problems      Glossary      Credits      Index   

About the Author :
<>Mark F. Sanders has been a faculty member in the Department of Molecular and Cellular Biology at the University of California, Davis for 27 years. In that time, he has taught more than 120 genetics courses to more than 30,000 undergraduate students. Specializing in teaching the genetics course for which this book is written, Dr. Sanders also teaches a genetics laboratory course, an advanced human genetics course for biology majors, and a human heredity course for non-science majors.  His teaching experience also includes introductory biology, and courses in population genetics and evolution.    Dr. Sanders received his Bachelors degree in Anthropology from San Francisco State University and his Master’s and Ph.D. degrees in Biological Anthropology from the University of California, Los Angeles.  Following graduation, he spent four years at the University of California, Berkeley as a post-doctoral researcher studying inherited susceptibility to human breast and ovarian cancer. At UC Berkeley he also taught his first genetics courses. Since coming to the University of California, Davis, Dr. Sanders has maintained a full-time teaching schedule and promotes academic achievement by undergraduate students in numerous ways, including as an active student advisor, through his on-going role as the director of a long-standing undergraduate student program, and by past service as the Associate Dean for Undergraduate Academic Programs in the College of Biological Sciences.   John L. Bowman is a Professor in the School of Biological Sciences at Monash University in Melbourne, Australia and an Adjunct Professor in the Department of Plant Biology at the University of California, Davis in the US. He received a B.S. in Biochemistry at the University of Illinois at Urbana-Champaign, Illinois in 1986 and a Ph.D. in Biology from the California Institute of Technology in Pasadena, California.  His Ph.D. research focused on how the identities floral organs are specified in Arabidopsis (described in Chapter 20).  He conducted postdoctoral research at Monash University on the regulation of floral development.  From 1996-2006 his laboratory at UC Davis focused on the developmental genetics of plant development, focusing on how leaves are patterned. From 2006-2011 he was a Federation Fellow at Monash University where his laboratory is studying land plant evolution using a developmental genetics approach.  At UC Davis he taught genetics, 'from Mendel to cancer', to undergraduate students, and continues to teach genetics courses at Monash University.


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Product Details
  • ISBN-13: 9780321948908
  • Publisher: Pearson Education (US)
  • Publisher Imprint: Pearson
  • Height: 276 mm
  • No of Pages: 880
  • Weight: 1882 gr
  • ISBN-10: 0321948904
  • Publisher Date: 11 Nov 2014
  • Binding: Paperback
  • Language: English
  • Sub Title: An Integrated Approach
  • Width: 216 mm


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