About the Book
This book is the published proceedings of the Sixth International Symposium on Trace Element Metabolism in Man and Animals. The Symposium was held at the Asilomar Conference Center in Pacific Grove, California, U.S.A. from May 31 through June 5, 1987. The decision to hold TEMA-6 at Asilomar was made at TEMA-5 in 1985. The International Guidance Committee decided to hold the meeting in California in part to recognize the significant cont~i- butions made to the field of trace element metabolism by Professor Lucille S. Hurley. As such, she was the obvious choice as chair of the local organ- izing committee. One of the principal goals of Professor Hurley was that TEMA-6 serve as a forum for discussing the use and application of newer methodologies, such as molecular biology, computer modelling and stable isotopes, in studies of trace element metabolism. Based on the comments which the local organizing committee has received, this goal was achieved. The Symposium was attended by 275 scientists from 32 countries covering 6 continents. Twenty-five speakers were chosen for our plenary sessions.
Table of Contents:
Selenium.- The Global Selenium Agenda.- The Predicament — How Should Selenoproteins be Hydrolyzed and Bioavailability Studies with Selenium Conducted?.- Bioavailability of Selenium in Wheat and Mushrooms as Assessed by a Short-term and a Long-term Experiment.- Selenium Status During Recovery from Malnutrition: Effect of Selenium Supplementation.- Selenium and Glutathione Peroxidase in Mothers Experiencing Sudden Infant Death Syndrome.- Selenium Responsive Conditions and the Concentrations of Selenium in Skeletal Muscle in Young Sheep.- Selenium Status Improved Among Elderly Due to Selenium-Enrichment of Fertilizers in Finland.- Apparent Proteolytic Modification of Glutathione Peroxidase.- Electron Transport and Metalloproteins.- Long-Range Electron Transfer in Ruthenium-Modified Proteins.- Factors Controlling the Rates of Electron Transfer in Proteins.- Kinetic Lability of Zn Bound to Metallothionein (Mt) in Ehrlich Cells.- The Cu-Thiolate Cluster in Mutants of Yeast Metallothionein.- Accumulation of Hepatic Zn7 and Zn/Cu Metallothionein in Copper-Loaded Chicks: Isolation and Characterization.- Factors Influencing the Accumulation of Metallothionein in Rat Blood Cells.- Trace Elements and Endocrine/Exocrine Function: Mn, Zn, Se.- Regulation of Pancreatic Exocrine Function by Manganese.- Effect of Manganese Deficiency on Glucose Transport and Insulin Binding in Rat Adipocytes.- Zinc Absorption in Pancreatic Insufficiency.- Identification of Abnormal Sites of Zn Transport and Metabolism in Patients with Sensory and Endocrine Disorders.- Selenium and Selenoproteins in Tissues with Endocrine Functions.- The Effect of Selenium Deficiency on Plasma Thyroid Hormone Concentrations and on Hepatic Tri-Iodothyronine Production.- Chelation and Other Vehicles for Therapy.- Pyridoxal Isonicotinoyl Hydrazone (PIH) and its Analogues: A New Group of Effective Chelators.- Iron Toxicity and Chelating Therapy.- Toxic and Essential Metal Loss During Chelation Therapy of Lead-Poisoned Children.- Use of Metal Chelating Agents to Modulate Ehrlich Cell Growth Multiple Metal-Ligand Interactions.- Effects of Chelating Compounds Formed on Food Processing on Zinc Metabolism in the Rat.- Changes in Zinc Metabolism During the Use of EDTA.- Trace Elements and Immune Function.- Trace Element Deficiencies and Immune Responsiveness.- Immune Responses as Parametres for Selenium Tolerance Determination in Sheep.- The Mobilization of Storage Iron as a Determinant of Refeeding Infection.- Inflammation-Related Changes in Trace Elements, GSH-Metabolism, Prostaglandins, and Sialic Acid in Bovine Mastitis.- The Effects of Dietary Mo on Ovine Host and Intestinal Parasite.- Trace Elements and Endocrine/Exocrine Function: Cu, Ca, I.- Influence of Hormones on Copper Metalloprotein Levels.- Norepinephrine and Dopamine Distribution in Copper-Deficient Mice.- Effect of Copper Deficiency on Enzyme Secretion from Isolated Pancreatic Acini.- Differential Effect of Copper Deficiency on Plasma Atrial Natriuretic Peptides in Male and Female Rats.- Sexual Differences in Copper Deficiency.- Calmodulin Concentration in Tissues of Zinc and Calcium Deficient Rats.- Effects of Calmodulin Inhibitors on the Cellular Metabolism of 45Ca and 210Pb.- Effect of Moderate Environmental Iodine Deficiency on Adolescent Girls.- Mechanisms of Trace Element Transport.- Transport, Subcellular Distribution and Export of Mn(II) in Rat Liver and Hepatocytes.- Extracellular Transport of Trace Elements.- Incorporation of Copper into Superoxide Dismutase in Culture.- The Role of Albumin in Copper Uptake by Hepatocytes and Fibroblasts.- Structure and Function of Transcuprein, in Transport of Copper by Mammalian Blood Plasma.- Differences in Cu-Transport by Hepatocytes and Fibroblasts.- Neonatal and Adult 64Copper Metabolism in the Pig and Its Relationship to Copper Metabolism in Wilson’s Disease.- Epidemiological Studies of Trace Element Nutrition in Man and Animals.- The Role of Selenium in Special Endemic Diseases and Cancer in China.- Wildlife as Indicators of Enzootic Selenium Deficiency.- An Epidemiological Study of a Defined Area of N. Ireland: Serum Zn and Cu.- Zinc, Iron and Copper in the Nutrition of Australian Aboriginal Children.- A Re-Appraisal of the Recommended Zinc Requirements for Grazing Livestock.- The Utilization of Hens’ Eggs as a Selenium Monitor in Epidemiological Studies.- Mineral and Trace Element Nutrition of Sheep in Gansu Province, Northern China.- Trace Element Interactions 1.- The Epistemology of Trace Element Balance and Interaction.- Subcellular Changes and Metal Mobilisation in the Livers of Copper-Loaded Rats.- The Interactions among Fe, Zn and Cu Affecting Liver Cu and Femur Zn Concentrations in the Rat.- Interactions between Zinc and Vitamin A Metabolism in Rats and Swine.- Zinc, Copper and Iron Concentrations in Tissues of Anencephalic and Control Fetuses.- Effects of Dietary Boron, Aluminum and Magnesium on Serum Alkaline Phosphatase, Calcium and Phosphorus, and Plasma Cholesterol in Postmenopausal Women.- Trace Elements in Infancy: a Supply/Demand Perspective.- Trace Elements and Development.- Trace Elements in Malnourished Populations.- The Role of Zinc in Prenatal and Postnatal Development.- Teratogenesis as a Function of Maternal Age in Zinc-Deficient Rats.- Zinc Supplements in Infants with Failure to Thrive: Effects on Growth.- Zinc Retention in Relationship to Fat-Free Body and Calcium Accretion in Early and Late Pregnancy.- Zinc (Zn) Absorption in Premature Infants.- Zinc Balance in Premature infants Fed Their Mothers’ Milk: Effect of Postnatal Age.- Trace Element Interactions 2.- Trace Mineral and Calcium Interactions.- Dietary Phytate:Zinc and Phytate x Calcium:Zinc Ratios of Lacto-Ovo Vegetarian Trappist Monks.- Zinc, Iron and Copper Interactions in Humans, Rats and Chicks.- Inhibition of Iron Absorption in Man by Manganese and Zinc.- Lipid Parameters in Wilson’s Disease Patients on Zinc Therapy.- Effects of Modest Amounts of Wheat Bran and Dietary Protein on Mineral Metabolism of Humans.- Trace Elements and Free Radicals.- First Description of a Variant of E. coli Lacking Superoxide Dismutase Activity Yet Able to Grow Efficiently on Minimal, Oxygenated Medium.- Effect of Selenium (Se) on Peroxidation and Glutathione (GSH) Levels in Murine Mammary Cells.- The Relationship Between Manganese Intake and the Activity of Manganese Superoxide Dismutase in Tissues of Sheep.- Effects of Selenium Intake on the Activity of Superoxide Dismutase and Glutathione Peroxidase and on Malondialdehyde Excretion During the Development of Rat Mammary Carcinogenesis.- Trace Elements, Free Radicals and Lipoperoxidation in Rats.- Contrasting Effects of Selenium and Vitamin E Deficiency on the Anti-Malarial Action of Qinghaosu in Mice.- The Effect of Selenium and Vitamin E Deficiencies on the Spin Trapping of Free Radicals in Homogenates of Rat Heart.- Trace Elements in Calcified Tissues and Matrix Biology.- Trace Elements in Calcified Tissues and Matrix Biology.- The Extracellular Matrix.- The Role of Trace Elements in the Development of Cartilage Matrix.- Enhanced Maternal Transfer of Fluoride in the Magnesium-Deficient Rat.- Dietary Boron Affects Bone Calcification in Magnesium and Cholecalciferol Deficient Chicks.- The Role of Copper and Cross-Linking in Elastin Accumulation.- A Silicon and Aluminum Interaction in the Rat.- Molecular Biology of Trace Element Function and Metabolism.- Coordinate Regulation of Zinc Metabolism and Metallothionein Gene Expression by cAMP, Interleukin-1 and Dietary Copper and Zinc.- Metallothionein and Ceruloplasmin Genes.- Metallothionein mRNA Levels in Normal and Mottled Mouse Mutants During Development.- Age Dependence of Metallothionein Inducibility in Mouse Liver.- Cytosolic Cu-Binding Components and the Brindled Mouse Defect.- 5S Ribosomal RNA Synthesis in Zinc-Deficient Rats.- Regulation of the Genes Involved in the Utilization of Molybdenum.- Trace Element Interactions 3.- Mechanisms and Nutritional Importance of Trace Element Interactions.- Effects of Dietary Molybdenum and Iron on Copper Metabolism in Calves.- Accumulation of Cu and Mo by the Foetus(es) and Conceptus of Single and Twin Bearing Ewes.- Influence of Breed and Dietary Cu, Mo and S Levels on Biliary Cu Excretion in Cattle.- Interactions Between Proteins, Thiomolybdates and Copper.- Antagonistic Effects of a High Sulphur, Molybdenum and Cadmium Content of Diets on Copper Metabolism and Deficiency Symptoms in Cattle and Pigs.- Heliotrope Alkaloids and Copper.- Interrelationships Between Molybdenum and Copper in Female Rats.- Posters: Selenium.- Effects of Transsulfuration Defects on Selenium Status.- Antioxidant Supplementation for Elderly Living at a Nursing Home: A Double-Blind Randomized One Year Clinical Trial.- Evidence of Selenium Deficiency in Mice Fed a Soy-Based Diet.- Determination of Selenium and Multiple Stable Isotope Enrichment of Selenium in Biological Materials by Inductively Coupled Plasma Mass Spectrometry.- Glutathione Peroxidase, Vitamin E and Polyunsaturated Fatty Acid Content of Tissues of Pigs with Dietetic Microangiopathy.- Identification of Selenium Containing Proteins from Soybeans.- Influence of Dietary Methionine on Selenomethionine Metabolism in Rats.- Purification and Properties of the Human Plasma Selenoenzyme, Glutathione Peroxidase.- Effect of a Shipment of High-Selenium Wheat on Selenium Status of Otago (N.Z.) Residents.- Transfer of Selenium from Different Dietary Sources into Plasma and Milk of Dairy Cow.- Erythrocyte and Plasma Glutathione Peroxidase: Two Distinct Selenium Containing Proteins.- GSH-Px Activity in the in Tissues After Selenium Blood Compared with Selenium Concentration Supplementation of Inorganic or Organic Selenium.- Selenium and Glutathione Peroxidase Status in Term Infants Fed Human Milk, Whey-Predominant, or Soy-Based Infant Formula.- Influence of Cysteine on Mucosal Uptake of 75-Se-Selenite by Sheep Jejunum.- Distribution of Selenium and Glutathione Peroxidase in Plasma from Healthy Subjects and Patients with Rheumatoid Arthritis.- Plasma Selenium and Glutathione Peroxidase in Relation to Cancer, Angina Pectoris and Short-Term Mortality in 68 Year Old Men.- Biological Functions of Silicon, Selenium, and Glutathione Peroxidase (GSH-Px) Explained in Terms of Semiconduction.- Influence of Glutathione Depletion on Hepatic Copper Uptake and Biliary Copper Excretion in the Rat.- Trace Elements and Lipid Metabolism.- Effect of Zinc Deficiency on Lipid and Protein Profiles of the Rat Erythrocyte Membrane.- Effects of Lead Deficiency on Lipid Metabolism.- An Association of Zinc with Omega-6-Fatty Acid and cAMP Synthesis in Melanoma Cells.- Effect of Non-Steroidal Anti-Inflammatory Drugs and Prostaglandin E2 on Zinc Absorption in Humans.- Zinc Decreases Lipid and Long Chain Fatty Acid Release from the Rat Mesenteric Vascular Bed Perfused In Vitro.- Rat Heart Performance and Lipid Metabolism is Affected by Copper Intake.- Tissue Fatty Acid Responses to Selenium and Vitamin E Deficiency and Oral C18:3,n-3 in Cattle.- Trace Elements and Endocrine/Exocrine Function.- Pancreatic Superoxide Dismutase Activity in the Copper-Depleted Rat.- Controlled Exercise Effects on Chromium, Copper and Zinc in the Urine of Trained and Untrained Runners Consuming a Constant Diet.- The Role of Zinc on the Trophic Growth Factors, Nerve Growth Factor and Gustin.- The Effects of High and Low Chromium Yeast Supplementation on Glucose Metabolism of Noninsulin Dependent Diabetic Patients.- Stress Induced Changes in Indices of Zinc, Copper, and Iron Status in U.S. Navy SEAL Trainees.- Zinc-dependent Failure of Thymic Hormone in Human Pathologies.- Trace Elements and Immune Function/Bacteriology.- Effect of Cobalt Deficiency on the Immune Function of Ruminants.- The Effect of Excess Zinc on cAMP Synthesis as a Regulatory Factor in Tumour Cell Proliferation.- Zinc and the Bacteriostatic Quality of Human Milk.- Trace Element and Macro Electrolyte Behaviour During Inflammatory Diseases in Cattle and Sheep.- Trace Element Transport.- Genetic and Biochemical Analysis of Copper Transport in Escherichia coli.- Effect of Prior Luminal Washing on Iron Absorption from Duodenum and Jejunum in Mice: Do Luminal Factors Mediate the Absorption of Iron?.- Pathobiochemical Aspects to the Mechanism of Zinc Absorption.- The Effect of Saponins on Mineral Availability.- Rate of Passage of Chromium III Thru the Small Intestine.- Cd-Binding Proteins Anchoring to Mucosal Brush Border Membrane from Rat Small Intestinal Tract.- Zinc Accumulation by Hepatocytes Isolated from Male Rats of Different Zinc Nutritional Status.- Identification of Five Sites of Regulation of Human Zn Metabolism.- Saturable Zinc Uptake by Syncytiotrophoblast Microvillous Plasma Membrane Vesicles from Human Placenta.- Nickel Absorption and Elimination in Human Volunteers.- Influence of Feed Components in Semisynthetic Diets on Cadmium Retention in Chicks.- The Effect of Dietary Fiber and Different Concentrations of Zinc on the Intestinal Absorption of Cadmium in Rats.- Transferrin Receptors and Iron Uptake of Rat Mammary Gland Membranes During Lactation.- Trace Element Deficiencies and Their Assessment.- Prediction of Disorder in Cu-Deficient Lambs from Different Genotypes.- Metal Analysis of Human Liver as an Aid to Diagnosis.- The Use of Multivariate Analysis to Identify Limiting Trace Elements in Sheep.- Concentration and Distribution of Zinc, Copper and Iron in “Zinc Deficient” Human Milk.- Effects of Heat Treatment of Defatted Soy Flour Fed to Young Japanese Quail.- Comparison of Indices of Copper Status in Men and Women Fed Diets Marginal in Copper.- Beer Increases the Longevity of Rats Fed a Diet Deficient in Copper.- The Influence of Zinc Deficiency on the Storage of Zinc in Bone.- Evaluation of Some Factors That May Affect Plasma or Serum Zinc Concentrations.- Ceruloplasmin and Glutathione Peroxidase as Copper and Selenium Indicators in Mink.- Copper and Iron Status of Calves in Relation to Plasma Protein Polymorphism.- Further Data on the Biological Essentiality of Nickel.- Altered Glucuronyl Transferase Activity in Magnesium Depleted Rats.- The Prediction of Impaired Growth Due to Cu, Co and Se Deficiencies in Lambs on Improved Hill Pastures in Scotland.- Zn Deficiency in the Rat: Relationship between Growth and Metal Content and Distribution.- Activation of Rat Erythrocyte Superoxide Dismutase by Copper.- Trace Elements and Clinical Nutrition.- Kinetics of Chromium in Patients on Continuous Ambulatory Peritoneal Dialysis.- The Influence of Body Mass Index and Hypoglycaemic Drugs on the Circulating and Excreted Levels of Chromium Following an Oral Glucose Challenge, in Subjects With and Without Diabetes Mellitus.- Serum Aluminum Levels in Dialysis Patients.- Dietary Intakes and Serum Levels of Selected Trace Elements in Institutionalized Elderly.- Mineral Status of Adults Given a Fiber Supplement.- Daily Variations in Plasma Zinc in Normal Adult Women.- Urinary Excretion (24 Hours) of Zinc and Copper in Normal Vegetarian and Non-Vegetarian Female Subjects During the Different Seasons: A Preliminary Studies.- Hepatic Trace Elements in Kwashiorkor.- Trace Element Bioavailability.- Improved Zinc Bioavailability from Colloidal Calcium Phosphate-Free Cow’s Milk.- Effects of Soybean Trypsin Inhibitor on Tissue Zinc in Weanling Male Long-Evans Rats.- Calcium and Zinc Absorption from Human Milk, Soy Formula and Dephytinized Soy Formula.- Distribution of Zinc in Human Milk and Cow’s Milk after In Vitro Proteolysis.- The Availability of Zinc, Cadmium and Iron from Different Grains Measured as Isotope Absorption and Mineral Accumulation in Rats.- Bioavailability of Iron Fortification Compounds Assessed by a Rat Model.- Manganese Absorption from Human Milk, Cow’s Milk and Infant Formulas.- Influence of Calcium and Phosphorus on the Absorption of Manganese as Determined by Plasma Uptake Tests.- Tissue Uptake of Manganese as a Measure of Its Bioavailability for Chicks.- Trace Element Epidemiology.- An Epidemiological Study of a Defined Area of N. Ireland: Whole Blood Glutathione Peroxidase (EC 1.11.1.9).- Hair Chromium as an Index of Chromium Status of Tannery Workers.- Familial Trends in Heavy Trace Metal Body Burdens in a Small Rural Community.- Cadmium, Zinc and Calcium in Human Kidneys.- Ante Mortem v. Post Mortem Changes in Chronic Cadmium Poisoning.- Accurate Assessment of the Intake of Dietary Components by Human Subjects.- Reference Values for Trace Element Concentrations in Whole Blood, Serum, Hair, Liver, Milk, and Urine Specimens from Human Subjects.- Trace Elements in Human Milk: An Australian Study.- Trace Element Interactions.- Copper and Molybdenum Levels in Tissues of Hypercuprotic Sheep During and After Being Fed Different Levels of Molybdenum.- Increased Sulfide Concentration in the Rumen Fluid of Sheep Does Not Decrease the Solubility of Copper.- Effect of High Dietary Iron and Ascorbic Acid on Copper and Iron Utilization During Copper Deficiency.- Interaction of Gold and Selenium after Injection to Mice.- Effects of Arsenic on the Intestinal Absorption of 75Se Compounds in Chicks.- Chromium and Vanadate Supplementation of Obese and Lean Mice.- The Effect of Parenteral Iron Administration upon Manganese Metabolism.- The Effect of Age and Sex upon Iron-Manganese Interaction in Different Segments of the Rat’s Intestine.- Mineral-Zinc and Protein-Zinc Interactions in Man.- Mineral Balance Study of Rats Fed Maillard Reaction Products.- Binding of Zinc to Colloidal Calcium Phosphate.- Iron-Zinc Interactions in Relation to Infant Weaning Foods.- Iron Status of Very Low Birthweight Pre-Term Infants Receiving a Zinc Supplement.- Production of Mg Deficiency Anemia by Zn and Phytate in Young Japanese Quail.- Hepatic and Splenic Content of Iron, Copper, Zinc, and Manganese in Anemic Mink.- Copper Status and Cadmium Administration: Effects on Zinc Distribution, Metallothionein, and Superoxide Dismutase Activity in Liver.- Boron and Methionine Status of the Rat Affects the Plasma and Bone Mineral Response to High Dietary Aluminum.- Effect of Molybdenum on Hepatic Enzymes and Minerals of Female Rats.- An Interaction Between Dietary Vanadium and Riboflavin in Chicks.- Demonstration of Ruminai Synthesis of Thiomolybdates and Their Subsequent Absorption in Sheep.- High Resolution Gamma-Ray Spectroscopy as an in vivo Tool for Following the Zinc-Selenium Interaction.- Effect of Fe Supplementation on Zn Status and the Outcome of Pregnancy.- Human Metabolic Study of Milk Simultaneously Fortified with Zinc, Iron and Copper.- Trace Elements and Development.- Age-Related Changes in Zinc and Copper Concentrations of Serum, Kidney, Liver, and Five Parts of the Brain of the Adult Rat.- Zinc Uptake by Brush Border Membrane Vesicles (BBMV) from Pre-Weanling Rat Small Intestine.- Maternal Glucose Homeostasis in Rats Given Marginal Zn Diets.- Pregnancy Complications, Labor Abnormalities and Zinc Status.- Is Spina Bifida in Man Linked to a Genetic Defect of Cellular Zinc Uptake in Children?.- Effects of Varying Dietary Zinc in Mice During Recovery from Undernutrition.- Altered Mineral Metabolism as a Mechanism Underlying the Expression of Fetal Alcohol Syndrome in Rats.- Action of High Dietary Copper in Promoting Growth of Pigs.- The Accumulation of Copper, Zinc, Manganese and Iron in the Foetus of Deer.- Effects of Molybdenum on Reproduction and Molybdenum/Copper Enzyme Activity in the Female Rat.- Defective Hepatic Copper Storage in the Brindled Mouse.- Zinc, Copper and Iron Metabolism by Turkey Embryo Hepatocytes.- Perinatal Development of Superoxide Dismutase in Rat Liver and Kidney.- The Amenity and Annoyance: The Circadian Rhythm, the Function of Limbic System and the Metal Metabolism in Mice.- Marginal Zn Deficiency Affects Pup Brain Microtubule Assembly in Rats.- Effects of Maternal Dietary Zinc on the Expression of Diabetes-Induced Teratogenicity in the Rat.- Trace Element Requirements of Grazing Animals.- The Effect of Monensin Sodium on Trace Element Status of Cattle at Pasture.- The Effects of Differing Compositions of Soluble Phosphate Glass Boluses on the Copper, Cobalt and Selenium Status of Swaledale Ewes.- The Effects of Soluble Glass Boluses upon the Copper and Selenium Status of Grazing Cattle.- The Effect of Different Compositions of Soluble Phosphate Glass Boluses on the Copper and Vitamin B12 Status of Growing Lambs.- A Preliminary Assessment of Controlled Release Devices for Supplementing Grazing Sheep with Trace Elements.- Efficacy of Selenium Pellets in Beef Cows.- The Development of a Long Acting Injectable Preparation for the Treatment and Prevention of Selenium Deficiency in Cattle.- Effect of Oral Copper Needles and Parenteral Copper on Hypocupraemia, Body Weight Gain and Fertility in Cattle.- Oxidized Copper Wire Particles as for Cattle an Oral Copper Supplement.- Investigations on Vanadium Deficiency in Ruminants.- Possibilities of Diagnosing Iodine Deficiency in Ruminants.- Normal Manganese, Zinc, Copper, Iron, Iodine, Molybdenum, Nickel, Arsenic, Lithium and Cadmium Supply Dependent on the Geological Origin of the Site and Its Effects on the Status of These Elements in Wild and Domestic Ruminants.- Pathology of Experimental Nutritional Degenerative Myopathy in Ruminant Cattle.- Treatment of Dairy Sheep with Soluble Glass Boluses.- Metallothionein.- Hormonal Modulation of Rat Hepatic Zinc Metallothionein Levels.- Effects of Zn-Deficiency and Valproate on Isometallothioneins in Fetal Rat Liver.- Uninduced Cu-Metallothionein and Other Cu-Binding Proteins in Mammals and Fish.- Instability at Low pH of Copper-Thionein-Proteins from Livers of Bedlington Terriers with Copper-Toxicosis.- Zinc, Copper and Metallothionein mRNA in Sheep Liver During Development.- Metallothionein Concentrations in the Blood and Urine of Streptozotocin Treated Rats.- Effects of Metallothionein Binding Capacity for Various Metals on Heme Oxygenase Activity.- Homeostasis of Trace Elements.- The Effect of Dietary Zn Before and After 65-Zn Administration on Absorption and Turnover of 65-Zn.- Effect of Long-Term Trace Element Supplementation on Blood Trace Element Levels and Absorption of 75Se, 54Mn and 65Zn.- Retention of Lead in Growing and Adult Rats Dependent on Varying Lead Supply.- Zinc Losses During Prolonged Cold Water Immersion.- Metabolic Adaptation of Gilts on Trace-Minerals in Response to Pregnancy and Low Dietary Zinc.- Trace Element Toxicity and Its Pathology.- An Episode of Zinc Toxicosis in Milk-Fed Holstein Bull Calves: Pathologic and Toxicologic Considerations.- Copper Tolerance in Rats — A Histochemical and Immunocytochemical Study.- Toxicosis of Developing Pigs Fed Selenium from Various Sources: Clinical Pathology.- Aluminum Induced Alteration in Hepatic Glucuronyl Transferase Activity.- Decrease of Serum Triglyceride and Essential Metal Changes in Normal Rats Fed with 2000 ppm Aluminum Diets.- Tissue Concentrations of Molybdenum After Chronic Dosage in Rats do not Follow Size of Dose.- Metallothionein and Copper in Human Liver — A Histopathological Study.- Analytical Techniques.- The Elemental Content of Some Trace Element Medicaments by Proton-Induced X-Ray and Gamma-Ray Emission Analyses.- The Application of a Synchrotron Radiation Microprobe to Trace Element Analysis.- Automated Determination of Blood Glutathione Peroxidase and the Effect of Storage, Cyanide and Drabkin’s Reagent.- Chemical Speciation of Metal Ions in the Ruminal and Abomasal Fluid of Sheep.
