Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids
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Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids

Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids


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About the Book

Newcomers to the field of biopharmaceuticals require an understanding of the basic principles and underlying methodology involved in developing protein- and nucleic acid-based therapies for genetic and acquired diseases. Introducing the principles of polymer science and chemistry, this book delineates the basic biology required for understanding how biomaterials can be used as drug-deliver vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Leading experts from around the world discuss the physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The book includes coverage biological barriers to extravasation and cellular uptake of proteins and nucleic acids.

Table of Contents:
Chapter 1 Structure, Properties, and Characterization of Polymeric Biomaterials, Chapter 2 Step-Growth and Ring-Opening Polymerization,  Chapter 3 Copolymers, Block Copolymers, and Stimuli-Sensitive Polymers,  Chapter 4 Polymer Solution Properties, Micelles, Dendrimers, and Hydrogels,  Chapter 5 Protein Conjugation, Cross-Linking, and PEGylation, Chapter 6 Complement Activation by Injectable Colloidal Drug Carriers,  Chapter 7 Bio1ogica1 Membranes and Barriers,  Chapter 8 Pharmacokinetics of Protein- and Nucleotide-Based Drugs,  Chapter 9 In vivo Fate of Polymerie Gene Carriers,  Chapter 10 Subcellular Fate of Proteins and Nucleic Acids, Chapter 11 Stability of Proteins and Nucleic Acids,  Chapter 12 Formulation, Stability, and Characterization of Protein and Peptide Drugs,  Chapter 13 Micro- and Nanoparticulate Polymerie Delivery Systems for Nucleic Acid-Based Medicine,   Chapter 14 Liposomal Delivery of Protein and Peptide Drugs,  Chapter 15 Mechanisms of Cellular Drug Resistance and Strategies to Overcome it,  Chapter 16 Transporters as Molecular Targets for Drug Delivery and Disposition,  Chapter 18 Introduction to Therapeutic Nucleic Acids,  Chapter 19 Antisense and Antigene Oligonucleotides: Structure, Stability and Delivery,  Chapter 20 Artificial Nucleic Acid Chaperones,  Chapter 21 Basic Components of Plasmid-based Gene Expression Systems,  Chapter 22 Design Elements of Polymerie Gene Carriers.

About the Author :
Ram I. Mahato is an assistant professor of pharmaceutics and drug delivery at the Departments of Pharmaceutical Seiences and Biomedical Engineering, University of Tennessee, Memphis.


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Product Details
  • ISBN-13: 9780203492321
  • Publisher: Taylor & Francis Inc
  • Publisher Imprint: CRC Press Inc
  • Language: English
  • No of Pages: 712
  • ISBN-10: 0203492323
  • Publisher Date: 28 Dec 2004
  • Binding: Digital (delivered electronically)
  • No of Pages: 712


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