Neuroimaging Genetics: Principles and Practices

The field of neuroimaging genetics has grown exponentially over the past decade. To date there are more than 10,000 published papers involving MRI, PET, MEG and genetics. Neuroimaging Genetics: Principles and Practices is the comprehensive volume edited by Drs. Bigos, Hariri, and Weinberger and co-authored by the preeminent scholars in the field. This text reviews the basic principles of neuroimaging techniques and their application to neuroimaging genetics. The work presented in this volume elaborates on the explosive interest from diverse research areas in psychiatry and neurology in the use of imaging genetics as a unique tool to establish and identify mechanisms of risk, establish biological significance, and extend statistical evidence of genetic associations. Examples throughout highlight the application of imaging genetics to understand neurochemical systems and pathways, explore relationships between genetics and the structural and functional connectivity in human brain, and provide insight into mechanisms of risk for psychiatric and neurologic illness.

Table of Contents:
1. Neuroimaging genetics Kristin L. Bigos, Ahmad R. Hariri, Daniel R. Weinberger Imaging Genetics and Neurochemistry 2.Molecular Neuroimaging Genetics Patrick M. Fisher, Gitte Moos Knudsen 3. Neuroreceptor Imaging of Genetic Variation Impacting the Serotonin Transporter Greg Perlman, Christine DeLorenzo, J. John Mann, Ramin Parsey 4. Imaging of Genetic Variation Impacting Dopamine Transmission Parameters Elsmarieke van de Giessen, Rassil Ghazzaoui, Raj Narendran, Anissa Abi-Dargham 5. Imaging Genetics of Dopamine Synaptic Terminal Activity Giuseppe Blasi, Alessandro Bertolino Imaging Genetics and Drug Discovery 6. Variability of Antidepressant Drug Response: Contribution of Imaging Genetics studies Ulrich Rabl, Bernhard M. Meyer, Lukas Pezawas 7. Imaging Genetics of Pharmacological Response in Psychiatric Disorders Philip R. Szeszko, Anil K. Malhotra Imaging Genetics and Genetic Discovery 8. Imaging Genetics of Williams Syndrome Daniel P. Eisenberg, Ranjani Prabhakaran, Karen F. Berman 9. Identifying Unanticipated Genes and Mechanisms in Serious Mental Illness: GWAS Based Imaging Genetics Strategies Steven G. Potkin, Theo G. M. van Erp, Shichun Ling, Fabio Macciardi, Xiaohui Xie 10. Imaging Genetics of Brain Structure Jason L. Stein, Derrek P. Hibar, Paul M. Thompson 11. Imaging Genetics of the Reward System Caroline F. Zink Imaging Genetics and Disease 12. Imaging Genetics of Schizophrenia Thomas M. Lancaster, Joanne L. Doherty, David E. Linden, Jeremy Hall 13. Imaging Genetics of Depression Matthew D. Sacchet, Lara C. Foland-Ross, Ian H. Gotlib 14. Imaging Genetics of Anxiety Disorders Mats Fredrikson 15. Imaging Genetics of Bipolar Disorder Martin Tesli, Ole A. Andreassen 16. Genetic-neuroimaging Studies of Basal Ganglia Disorders Trevor W. Robbins, James B. Rowe, Roger A. Barker 17. Imaging Genetics of Antisocial Behavior and Psychopathy Hayley M. Dorfman, Joshua W. Buckholtz Imaging Genetics and the Environment 18. Incorporating the Environment into Neurogenetics Research: An Imaging Gene by Environment Interactions (IG x E) Approach Luke W. Hyde, Ryan Bogdan, Ahmad R. Hariri Imaging Genetics and Cognition 19. Imaging Genetics of Episodic Memory Björn Rasch, Susanne Erk, Andreas Papassotiropoulos, Dominique J.-F. de Quervain 20. Imaging Genetics of Working Memory Tristram A. Lett, Eva J. Brandl, Daniel J. Müller, Andreas Heinz, Henrik Walter Imaging Genetics of Advancing Age 21. Neurobiology and Genetics of Cognitive Aging: Insights from Neuroimaging Studies John C. Muse, Milap A. Nowrangi, Daniel R. Weinberger, Venkata S. Mattay 22. Neuroimaging Genetics of Alzheimer's Disease Theresa M. Harrison, Alison C. Burggren, Susan Y. Bookheimer Imaging Genetics and Multi-Locus Models 23. Imaging Genetics of the Hypothalamic Pituitary Adrenal Axis: Implications for Psychopathology Nadia S. Corral-Frias, Lindsay J. Michalski, Christina R. Di Iorio, Ryan Bogdan Index

About the Author :
Kristin L. Bigos is Investigator at the Lieber Institute for Brain Development and Assistant Professor of Medicine in the Division of Clinical Pharmacology at Johns Hopkins School of Medicine. Ahmad R. Hariri is a Professor in the Department of Psychology and Neuroscience at Duke University. Daniel R. Weinberger is Director and CEO at the Lieber Institute for Brain Development and Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine.

Review :
"Neuroimaging Genetics: Principles and Practice edited by Bigos, Hariri and Weinberger is the first volume in the field devoted to this burgeoning area of research. It brings together many of the pioneering investigators in the field who collectively summarize the history and current state of the art... [and] includes both chapters on specific neurochemically defined circuits including serotonin and dopamine, as well as those that are more disease specific, e.g schizophrenia, Williams syndrome, anxiety disorders and bipolar disorder. ... For the interdisciplinary investigator/student at the interface of genetics, neuroradiology, psychiatry, and neurology, this will be an enjoyable, informative read." --Charles B. Nemeroff, MD, PhD, Leonard M. Miller Professor and Chairman, Department of Psychiatry and Behavioral Sciences, Director, Center on Aging, Leonard M. Miller School of Medicine, University of Miami, FL "In the few years since this method was initially conceived, imaging genetics has emerged as a valuable tool to understand mechanisms of psychiatric disease, understanding how genes work on the level of brain, and to guide the search for new treatments. ... Scholarly and practical at the same time, this book will be an asset to the library of researchers in psychiatry, neuroscience, and genetics, as well as for practitioners curious where the research frontier now lies." --Andreas Meyer-Lindenberg, MD, Director and CEO, Central Institute of Mental Health, Mannheim; and Chair of Psychiatry and Psychotherapy, University of Heidelberg / Medical Faculty Mannheim, Germany