The Antibody Molecule
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The Antibody Molecule: From antitoxins to therapeutic antibodies(Oxford Medical Histories)

The Antibody Molecule: From antitoxins to therapeutic antibodies(Oxford Medical Histories)


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About the Book

The Antibody Molecule follows the extraordinary journey of the medics and scientists who shaped the course of medical advances in the field of immunology. One of the oldest of the medical sciences, immunology has a history that has seen chemists, physicists and biologists alike seeking to unravel the most complex system in the human body outside the brain. This book charts its intriguing history, from the genetic basis of antibody diversity, through the understanding of the mechanism by which the immune system's first line of defence works, to breakthroughs in crystallography and the exploitation of immunoglobulins as therapeutic platforms to treat cancer, inflammation and allergy. Tracing the developments in immunology in chronological order, Professor Anthony R. Rees presents the historical contexts of the periods in rich detail, bringing them to life with quotes and illustrations. This fascinating book examines the literature of the time, turning points, and controversies. A must read for immunologists and life scientists, as well as historians of science and medicine.

Table of Contents:
1: Antibody pre-history: The emergence of empirical immunology 2: Pre-molecular immunology: The dawn of mechanism 3: Structural chemistry: Locks, keys and colloids 4: The foundations of antibody-antigen recognition emerge 5: The cellular reformation 6: The molecular path unfolds 7: Uncovering the origins of antibody diversity 8: Immunoglobulin constant regions 9: Effector functions of constant regions 10: Transmission and catabolism of IgG 11: The structural context of antibody diversity 12: Monoclonal antibodies and the mechanisms of hypermutation 13: Antibody structure prediction and development of humanization strategies 14: Antibody engineering: Improving on natural immunity 15: Therapeutic antibodies: Case study 1: Prevention of respiratory syncytial virus illness 16: Therapeutic antibodies: Case study 2: Targeting breast cancer 17: Antibodies: The therapeutic future

About the Author :
Anthony Rees is currently Principle at Rees Consulting AB, Uppsala, Sweden. He was lecturer in Molecular Biophysics and Student of Christ Church from 1980 to 1990 at the University of Oxford. From 1990-1997 he was Professor and Head of the School of Biology and Biochemistry, University of Bath where he is an Emeritus Professor and holds an Honorary Doctor of Science. In 1989 he was a scientific cofounder with Graham Richards of Oxford Molecular, which became one of the earliest UK biotechnology companies to be listed on the London Stock Exchange. He has been visiting Professor at the Universities of Montpellier and Lund, scientific director of the French company Synt:em, CEO of the Swedish company MIP Technologies and Chairman of the Board of the antibody technology company, F-star. He is a member of the American Association for the History of Science and has published more than 120 scientific papers, a number of books and is an inventor on more than 30 patents.

Review :
The Antibody Molecule is a marvelous synthesis of pertinent scientific literature from the late nineteenth century to the modern day, by someone who has an intimate firsthand knowledge of what it is like to have worked in this field. An enjoyable read and I would thoroughly recommend it to anyone who wants to learn about the stories that lie behind the modern textbook understanding of the antibody molecule and its therapeutic applications.


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Product Details
  • ISBN-13: 9780199646579
  • Publisher: Oxford University Press
  • Binding: Hardback
  • Language: English
  • Returnable: Y
  • Spine Width: 26 mm
  • Weight: 718 gr
  • ISBN-10: 0199646570
  • Publisher Date: 30 Oct 2014
  • Height: 242 mm
  • No of Pages: 384
  • Series Title: Oxford Medical Histories
  • Sub Title: From antitoxins to therapeutic antibodies
  • Width: 167 mm


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