About the Book
Opioids have played a prominent role in society for centuries and have been lauded for both their analgesic and euphoric qualities by cultures throughout the world. The advent of medical and pharmaceutical sciences in the 20th century ushered in a wide variety of different commercial opioid products that were designed to maximize their therapeutic potential. As the use of opioids increased, a corresponding need emerged to understand more about how opioids exert their effects in the body and brain; the consequences of opioid use regarding physical dependence, withdrawal, and craving; how we might best treat opioid use disorder (OUD) and address risk for opioid-related overdose; and how opioids may intersect with other clinical conditions to produce unique challenges.
Edited by Kelly E. Dunn, The Oxford Handbook of Opioids and Opioid Use Disorder synthesizes research across the spectrum, and establishes a foundational knowledge regarding historical and current epidemiological trends, neurobiological and genetic contributors to opioid effects and OUD, and core elements of opioid use such as withdrawal and craving. It provides specific information and guidance regarding opioid treatment paradigms, including chapters on specific pharmacotherapies as well as treatment approaches, and discusses considerations for special clinical populations. An overview of these respective issues is provided across 38 chapters, which outline the history and science of these topics alongside clinical considerations and case examples.
Written by expert bench scientists, epidemiologists, clinical trial interventionists, medical practitioners, and harm reduction specialists, this handbook will serve as a comprehensive guide for practitioners, policymakers, students, and researchers who wish to achieve a better understanding of the complex world of opioid and OUD practice and science.
Table of Contents:
Chapter 1: Historical Events that Shaped Contemporary Opioid Trends
Kelly E. Dunn
Chapter 2: Epidemiology of Opioid Use and Smoking, Alcohol, and Polysubstance Use Among Persons Using Opioids
Maria A. Parker and Whitney S. Cordoba-Grueso
Chapter 3 Opioid Use Disorder: Diagnostic History and Current Understanding
Orrin D. Ware and Kelly E. Dunn
Chapter 4: Access to Treatment for Opioid Use Disorder
Brendan Saloner and Jason Gibbons
Chapter 5: The Current Status of Medical Student Education on Opioids
Oluwole Jegede, Peter J. Na, Ismene Petrakis, and Srinivas B. Muvvala
Chapter 6: The Neurobiology of Opioid Use
Shailesh N. Khatri, Erin E. Maher, Emma O. Bondy, and Cassandra D. Gipson
Chapter 7: Genetic Influences in Opioid Use Disorder
Jill Rabinowitz and Brion Maher
Chapter 8: The Opioid Withdrawal Syndrome: Presentation, Measurement, and Management
Kelly E. Dunn, Cecilia Bergeria, Orrin D. Ware, Eric C. Strain
Chapter 9: Neonatal Abstinence Syndrome
Sarah H. Heil, Heidi S. Melbostad, and Leigh-Anne Cioffredi
Chapter 10: Opioid Craving: Understanding Its Measurement, Mechanisms, and Treatment
Cecilia Bergeria and Brandon Park
Chapter 11: Opioids and Cognition
Bethea A. Kleykamp, Shannon B. Clarke, and Shauna P. Acquavita
Chapter 12: Opioid Effects on Sleep: Review of the Literature and Consideration of the Hypothalamic-Pituitary-Adrenal Axis as a Relevant Mechanism
Jennifer D. Ellis, Chung Jung Mun, and Patrick H. Finan
Chapter 13: Fentanyl
Kelly E. Dunn, H. Elizabeth Bird, and Caitlyn J. Durgin
Chapter 14: Tramadol
Kelly E. Dunn, Judy Ashworth, and Eric C. Strain
Chapter 15: Kratom (Mitragyna speciosa): Pharmacology and Use of a Naturally Occurring Atypical Opioid
Kirsten E. Smith, Oliver Grundmann, Marc T. Swogger, and Albert Garcia-Romeu
Chapter 16: Ibogaine and Noribogaine
Deborah C. Mash and Michael Karukin
Chapter 17: Abuse Deterrent and Sustained Release Opioid Formulations
Rachel R. Luba, Sandra D. Comer, and Edward V. Nunes
Chapter 18: Methadone
Jonathan R. Buchholz, Molly Kalmoe, Justin Stamschror, and Andrew J. Saxon
Chapter 19: Buprenorphine
Eric C. Strain and Andrew Gaddis
Chapter 20: Naltrexone
Marina Tsoy-Podosenin and Evgeny Krupitsky
Chapter 21: Clonidine
Mark S. Gold and Kenneth Blum
Chapter 22: Lofexidine
Charles W. Gorodetzky, Kristen L. Gullo, and Marc Fishman
Chapter 23: Injectable Opioid Treatment
Eugenia Oviedo-Joekes
Chapter 24: Long-Term Treatment of Opioid Use Disorder With Medications
Aaron S. Wolfgang, Melissa B. Weimer, Peter J. Na, David A. Fiellin, and Srinivas B. Muvvala
Chapter 25: Supervised Withdrawal Opioid Use Disorder Treatments
Kelly E. Dunn and Andrew S. Huhn
Chapter 26: Psychosocial Treatment Methods
Jessica M. Peirce, Denis G. Antoine, Alexis S. Hammond, and Michael S. Kidorf
Chapter 27: Behavioral and Self-directed Treatments for Opioid Use Disorder
Wendy Insalaco and J. Gregory Hobelmann
Chapter 28: Contingency Management Treatment of Opioid Use Disorder
August F. Holtyn, Forrest Toegel, and Matthew D. Novak
Chapter 29: Treating Opioid Use During Pregnancy and Postpartum Life Phases
Hendrée E. Jones
Chapter 30: Pharmacy-Based Treatment Options for Opioid Use Disorder
Ali Cheetham and Suzanne Nielsen
Chapter 31: Opioid Overdose: Mechanisms and Naloxone
Jermaine D. Jones, Rachel R. Luba, Mudassir Mumtaz, and Felipe Castillo
Chapter 32: Opioid Overdose: Intervention Strategies
Laura Brandt
Chapter 33: Supervised Consumption Services
Jeanette Bowles, Meaghan Thumath, Gillian Kolla, Zoe Dodd, Jaime Arredondo Sanchez Lira, Frank Crichlow, and Leo Beletsky
Chapter 34: Psychiatric Comorbidities Among Persons Who Are Using Opioids
R. Kathryn McHugh
Chapter 35: Sex as a Biological Variable and Gender as a Social Construct in the Treatment of Opioid Use Disorder
Andrew S. Huhn
Chapter 36: Challenges of Opioid Use Disorder in Rural Settings
Stacey C. Sigmon and Jennifer R. Havens
Chapter 37: Differences Between Those Engaged in Heroin Use and Non-Prescribed Opioid Use
Ty S. Schepis, Bowie Duncan, and Katherine Vrotsos
Chapter 38: The Impact of Opioid Use Disorder on Families and Children
Erin L. Winstanley, Amanda Newhouse, and Kari-Beth Law
About the Author :
Kelly E. Dunn, PhD, MBA, is Professor of Psychiatry and Behavioral Sciences at Johns Hopkins University. Dunn has been working in the field of opioid use disorder since 2005, motivated by witnessing her community be ravaged with nonmedical use of prescription opioids as a teenager. This led to a passion for understanding motivations for opioid use, identifying methods to prevent the onset of opioid use disorder, improving treatments for opioid use
disorder, and exploring new methods for managing pain and reducing opioid reliance. She has built a robust portfolio of laboratory and clinical trial research investigating these questions and is an author of more than
100 peer-reviewed publications in the area of substance use and opioid use disorder.
