Mind, Brain, and Schizophrenia

Over the last two decades, molecular genetics and brain imaging have guided efforts to find the causes of schizophrenia. It is becoming increasingly clear that many genes are involved in schizophrenia and that they interact with other factors in very complex ways, which have not yet been elucidated. Neuroimaging techniques have allowed scientists and physicians to examine brain structure, function, and chemistry in living patients with schizophrenia but results so far have been disappointing. No two patients seem to share exactly the same combination of clinical symptoms or physical findings. Yet all have the syndrome recognized as schizophrenia. The author of this accessible, well-written book argues that it is time to set aside the search for a single cause of schizophrenia and focus on the disease's final common pathway. He highlights clues from a wide range of research, including neurotransmitter, psychophysiological, and brain imaging studies. He then describes possibilities for the final common pathway at an understandable level in the context of what is already known about schizophrenia. While there are no preferred models of schizophrenia, a pattern is emerging which implicates those structures in the brain known to be important in integrating perception, cognition, and affect. A better understanding of these processes will be critical for developing more effective treatments. This book will help advance that effort. It will be of great value to psychiatrists, psychologists, neurologists, neuroimagers, and basic scientists working in the field of schizophrenia research, and to their students and trainees. It will also be of interest to clinicians and scientists concerned with other neuropsychiatric disorders, and to the families of those diagnosed with schizophrenia.

Table of Contents:
1: The Evolving Concept of Schizophrenia 2: Candidate Neuronal Circuits 3: When Does Schizophrenia Begin? 4: Clues from Drugs Which Affect Dopamine, Glutamate, and Other Neurotransmitters 5: Clues from Psychophysiology 6: Neuropsychological Studies 7: Imaging Brain Structure in Living Patients 8: Imaging Brain Function in Living Patients 9: Imaging Brain Chemistry and the Question of Neuronal Degeneration 10: Likely Components of the Final Common Pathway 11: Early Models of the Final Common Pathway 1. Disconnection and Coordination 12: Early Models of the Final Common Pathway 2. Basal Ganglia-Thalamocortical Circuits 13: Do the Models Fit With What We Know About Schizophrenia? 14: Implications for Treatment 15: The Way Forward

Review :
"This is an excellent and comprehensive new book summarizing and synthesizing current findings from multiple disciplines on research in schizophrenia. Any clinician involved in research or the care of patients with this devastating disorder should have the knowledge contained in this book." --Doody's "We would, in fact, go as far as to state that this book should be compulsory reading for clinicians...The book provides very solid basic knowledge about this strange, disabling, and common syndrome. We recommend it to all psychiatrists, trainees in psychiatry, and other professionals who would like a better understanding of the brain, the mind, and schizophrenia."--New England Journal of Medicine "This book is a must-read for all students of psychiatry. It is written in limpid style that draws pictures with words, obviating the need for illustrations."--Canadian Journal of Psychiatry "This book is an excellent review of a wide spectrum of studies in schizophrenia and is intended for researchers working on the field of schizophrenia, for clinical psychiatrists, but also for all medical doctors with interest on a clinical syndrome with a high prevalence, a long-term morbidity and a marked deterioration in social and occupational functioning."--Journal of Chemical Neuroanatomy "This is a dense, logical, knowledgeable synthesis of the available data from neurotransmitter, psychophysiological, and brain imaging studies which bear on the etiology of schizophrenia."--Journal of Nervous and Mental Disease "This is an excellent and comprehensive new book summarizing and synthesizing current findings from multiple disciplines on research in schizophrenia. Any clinician involved in research or the care of patients with this devastating disorder should have the knowledge contained in this book." --Doody's "We would, in fact, go as far as to state that this book should be compulsory reading for clinicians...The book provides very solid basic knowledge about this strange, disabling, and common syndrome. We recommend it to all psychiatrists, trainees in psychiatry, and other professionals who would like a better understanding of the brain, the mind, and schizophrenia."--New England Journal of Medicine "This book is a must-read for all students of psychiatry. It is written in limpid style that draws pictures with words, obviating the need for illustrations."--Canadian Journal of Psychiatry "This book is an excellent review of a wide spectrum of studies in schizophrenia and is intended for researchers working on the field of schizophrenia, for clinical psychiatrists, but also for all medical doctors with interest on a clinical syndrome with a high prevalence, a long-term morbidity and a marked deterioration in social and occupational functioning."--Journal of Chemical Neuroanatomy "This is a dense, logical, knowledgeable synthesis of the available data from neurotransmitter, psychophysiological, and brain imaging studies which bear on the etiology of schizophrenia."--Journal of Nervous and Mental Disease "...concise and well organized. The style of writing is clear and devoid of jargon."--Journal of Clinical Psychiatry "...[C]oncise and well-organized...The pedagogy of the book is successful in reviewing a large body of primary data."--Psychiatrist.com