The Genetic Basis of Common Diseases: (44 Oxford Monographs on Medical Genetics)

Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult disease, and we now have a better understanding of the molecular processes involved in genetic susceptibility and disease mechanisms. The Second Edition fully incorporates these advances. The entire book has been updated and twelve new chapters have been added. Most of these chapters deal with diseases such as gallstones, osteoporosis, osteoarthrits, skin cancer, other common skin diseases, prostate cancer and migraine headaches that are seen by all physicians. Others address the genetic and molecular basis of spondyloarthropathies, lupus, hemochromatosis, IgA deficiency, mental retardation, hearing loss, and the role of mitochondrial variation in adult diseases. Chapters on the evolution of human genetic disease and on animal models add important background on the complexities of these diseases. Unique clinical applications of genetics to common diseases are covered in additional new chapters on genetic counselling, pharmacogenetics, and the genetic consequences of modern therapeutics.

Table of Contents:
Part I Approaches 1: Richard A. King, Jerome I. Rotter, and Arno G. Motulsky: Approach to Common Bases of Common Diseases 2: Jeffrey R. Smith, Thomas D. Gelehrter, Francis S. Collins (JS: Vanderbilt; TG: University of Michigan; FC: National Human Genome Research Institute): Molecular Genetics of Common Diseases 3: Stephen S. Rich and Thomas A. Sellers (SR:Wake Forest University School of Medicine; TS: Mayo Clinic and Mayo Foundation): Genetic Epidemiologic Methods 4: Jared Diamond and Jerome I. Rotter (University of California, Los Angeles, both): The Evolution of Human Genetic Diseases 5: Aldons J. Lusis, David West, and Richard C. Davis (AL, DW: University of California, Los Angeles; RD: Parke-Davis Pharmaceuticals): Animal Models of Complex Genetic Disease 6: Bonnie S. LeRoy and Ann P. Walker (BL: University of Minnesota; AW: University of California, Irvine): Genetic Counseling: History, Risk Assessment, Strategies, and Ethical Considerations Part II Cardiopulmonary Diseases 7: Arno G. Motulsky and John D. Brunzell (University of Washington, both): Genetics of COronary Atherosclerosis 8: Steven C. Hunt, Paul N. Hopkins, Jean-Marc Lalouel (University of Utah, all): Hypertension 9: Francine Kauffmann and Florence Demenais (INSERM, both): Chronic Obstructive Pulmonary Disease Part III Immunologic and Infectious Diseases 10: Ellen Buschman, Emil Skamene, and Erwin Schurr (EB, EmilS: McGill University Health Centre; ErwinS: Mc Gill Centre for the Study of Host Resistance): Genetics of Human Susceptibility to Infectious Diseases: Progress and Prospects 11: Deborah A. Meyers, Denise G. Wiesch, and Eugene R. Bleecker (DM, EB: Wake Forest University School of Medicine; DW: National Institute of Allergy and Infectious Disease): Genetics of Asthma and Bronchial Hyperresponsiveness 12: Harry W. Schroeder, Jr. (University of Alabama at Birmingham): IgA Deficiency and Common Variable Immunodeficiency Part IV Gastrointestinal Disorders 13: A.S. Pena (Vrije Universiteit Medical Center): Peptic Ulcer and Gastritis 14: Edward J. Hollox and Dallas M. Swallow (EH: University Nottingham; Ds: University College London): Lactase Deficiiency: Biological and Medical Aspects of the Adult Human Lactase Polymorphism 15: Inflammatory Bowel Disease.Huiying Yang and Krent D. Taylor (UCLA School of Medicine, both) 16: Beverly Paigen and Martin C. Carey (BP: The Jackson Laboratory; MC: Harvard Medical School): Gallstones 17: Albert J. Czaja (Mayo Clinic and Mayo Foundation): Chronic Liver Disease 18: Frances Busifield, G.J. Anderson, and L.W. Powell (The University of Queensland, Australia, all): Hereditary Hemochromatosis 19: Susan L. Neuhausen and John J. Zone (University of Utah, both): Gluten-Sensitive Enteropathy Part V Endocrine Disorders 20: Stefan K.G. Grebe (University of Outago, New Zealand): Thyroid Disease 21: Steven C. Elbein, Ken C. Chui, and M. Alan Permutt: Type 1 Diabetes Mellitus 22: Steven C. Elbein, Ken C. Chin, and M. Alan Permutt (SE: Univerity of Arkansas for Medical Sciencs; KC: UCLA School of Medicin; MP: Washington University School of Medicine): Type 2 Diabetes Mellitus 23: George Bray and Claude Bouchard (Louisiana State University, both): Obesity 24: Tatiana Foroud, Michael J. Econs, and C. Conrad Johston, Jr. (Indiana University School of Medicine, all): Genetics of Osteoporosis 25: Michael A. Becker (The University of Chicago Pritzker School of Medicine): Hyperuricemia and Gout Part VI Genitourinary Disorders 26: Joe Leigh Simpson (Baylor College of Medicine): Genetics of Gynecologic Disorders 27: Carole Ober, Marion S. Verp, Kenneth P. Roberts, and Jon L. Pryor (CO, MS: University of Chicago; KR, JP: University of Minnesota): Genetics of Infertility and Pregnancy Loss Part VII Rheumatologic Diseases 28: Gerald T. Nepom and Henry A. Erlich (GN: University of Washington School of Medicine; HE: Roche Molecular Systems): Immunology and Immunogenetics 29: Barbara Nepom and Richard A. King (BN: Virginia Mason Research Center, RK: University of Minnesota): Rheumatoid Arthritis 30: R. Hal Scofield (University of Oklahoma): Seronegative Spondyloarthropathies 31: Patrick M. Gafney, Richard A. King, and Timothy W. Behrens (University of Minnesota, all): The Genetics of Systemic Lupus Erythematosus 32: John Loughlin and Kay Chapman (University of Oxford, both): Genetic Basis of Primary Osteoarthritis 33: Reed E. Pyeritz (University of Pennsylvania School of Medicine): Common Disorders of Connective Tissue Part VIII Cancer 34: Randall W. Burt (University of Utah Health Sciences Center): Gastrointestinal Cancer 35: Katherine L. Nathanson and Barbara L. Weber (University of Pennsylvania, both): Breast Cancer 36: Thomas A. Sellers and Ping Yang (Mayo Clinic, both): Familial and Genetic Influences on Risk of Lung Cancer 37: Maren T. Scheuner and Beth Y. Karlan (UCLA School of Medicine, both): Reproductive Organ Cancers 38: Allen E. Bale, Suzanne J. Brown, and William D. Posten (Yale University School of Meidicine, all): Skin Cancer 39: William B. Isaacs and Jianfeng Xu (WI: Johns Hopkins University; JX: Wake Forest University School of Medicine): Prostate Cancer 40: Marshall Horwitz (University of Washington School of Medicine): Hematologic Cancer Part IX Neuropsychiatric Disorders 41: Magali Fernandez and Thomas D. Bird (MF: Ohio State University; TB University of Washington School of Medicine): Epilepsy 42: Leena Peltonen, Janna Saarela, and Satu Kuokkanen (LP: UCLA School of Medicine; JS: University of Helsinki; SK: Columbia University): Genetic Basis of Multiple Sclerosis 43: Margaret A. Pericak-Vance and Jonathan L. Haines (MP-V: Duke University Medical Center; JH: Vanderbilt University Medical Center): The Genetics of Alzheimer Disease 44: Servilla D. Detera-Wadleigh and Lynn R. Goldin (SD-W: National Institute of Mental Health; LG: National Cancer Institute): Genetics of Affective Disorders 45: Ann E. Pulver, Godfrey Pearlson, John McGrath, Virginia Keyes Lasseter, Karen Swarts, and George Papadimitriou (GP: Athens University Medical School: All others: Johns Hopkins University): Schizophrenia 46: Dharam P. Agarwal (University of Hamburg): Alcoholism 47: W. Ted Brown (SUNY Downstate Medical Center): Mental Retardation 48: Rena Ellen Falk and Nathan Fischel-Ghodsian (UCLA School of Medicine, both): Hereditary Hearing Loss 49: Aarno Palotie, Robert Baloh, and Maija Wessman (AP, RB: UCLA School of Medicine; MW: University of Helsinki): Genetics of Migraine Part X Other Common Problems 50: Virginia P. Sybert (University of Washington School of Medicine): Common Skin Disease 51: George M. Martin (University of Washington School of Medicine): Genetic Modulation of Aging and Longevity 52: Douglas C. Wallace and Marie T. Lott (Emory University, both): Mitochondrial Defects in Commons Diseases 53: Georgia L. Wiesner, David B. Everman, and Suzanne B. Cassidy (GW: Case Western Reserve University; DE: Greenwood Genetic Center; SC: University of California, Irvine): Constitutional Chromosome Disorders in Adults Part XI Therapy 54: John J. Mulvihill, Sarah F. Whitton, and Patrick H. Horn (University of Oklahoma College of Medicine, all): Genetic Consequences of Modern Therapeutics: Iatrogenic Mutagensis 55: Werner Kallow (University of Toronto): Pharmacogenetics, Ecogenetics, and Pharmacogenomics

Review :
From reviews of the first edition: "The Genetic Basis of Common Diseases is an excellent compilation of current knowledge....I use this fine book daily and look forward to subsequent editions."--Journal of the American Medical Association "Future generations of physicians may look back at the first edition of this book much the way we now percieve Osler's Principles and Practice of Medicine, initially published in 1892, as the first in a long line of episodic revisions that acquired many competitors along the way...this new work stands alone and is a worthy addition to the literature of internal medicine."--Annals of Internal Medicine "The organizational aspects of the text make the information readily retrievable...This useful reference text is not only relevant to the student seeking a basic understanding of a particular disease, it is relevant to the physician through its discussion of treatments and to the genetic couselor through its presentation of genetic risk information for families."--International Journal of Experimental and Clinical Investigation "This text follows the tradition of excellence of the Oxford Monographs in Medical Genetics."--Neuromuscular Disorders From reviews of the first edition: "The Genetic Basis of Common Diseases is an excellent compilation of current knowledge....I use this fine book daily and look forward to subsequent editions."--Journal of the American Medical Association "Future generations of physicians may look back at the first edition of this book much the way we now percieve Osler's Principles and Practice of Medicine, initially published in 1892, as the first in a long line of episodic revisions that acquired many competitors along the way...this new work stands alone and is a worthy addition to the literature of internal medicine."--Annals of Internal Medicine "The organizational aspects of the text make the information readily retrievable...This useful reference text is not only relevant to the student seeking a basic understanding of a particular disease, it is relevant to the physician through its discussion of treatments and to the genetic couselor through its presentation of genetic risk information for families."--International Journal of Experimental and Clinical Investigation "This text follows the tradition of excellence of the Oxford Monographs in Medical Genetics."--Neuromuscular Disorders "the most authoritative genetics book yet published on multifactorial disease...The unique nature of this book, besides being one of a kind, lies in its concise summarizing of often a huge body of prior work from very diverse sources, and in its attempt to facilitate research by providing an overview. This book has no peer and this second edition will deservedly become a classic."--Doody's "This book will be useful for physicians with a particular interest in medical genetics, genetic counseling, and epidemiology, and it will be a helpful tool for those who wish to learn more about the genetic components of multifactoral diseases."--New England Journal of Medicine