About the Book
What are the boundary zones between normal aging and Alzheimer's disease (AD)? Are many elderly people whom we regard as normal actually in the early stages of AD? Alzheimer's disease does not develop overnight; the early phases may last for years or even decades. Recently, clinical investigators have identified a transitional condition between normal aging and and very early Alzheimer's disease that they have called mild cognitive impairment, or MCI. This term typically refers to memory impairment beyond what one would expect in individuals of a given age whose other abilities to function in daily life are well preserved. Persons who meet the criteria for mild cognitive impairment have an increased risk of progressing to Alzheimer's disease in the near future. Though many questions about this condition and its underlying neuropathology remain open, full clinical trials are currently underway worldwide aimed at preventing the progression from MCI to Alzheimer's disease. This book addresses the spectrum of issues involved in mild cognitive impairment, and includes chapters on clinical studies, neuropsychology, neuroimaging, neuropathology, biological markers, diagnostic approaches, and treatment. It is intended for clinicians, researchers, and students interested in aging and cognition, among them neurologists, psychiatrists, geriatricians, clinical psychologists, and neuropsychologists.
Table of Contents:
1: Introduction, Ronald C. Petersen
2: Clinical Features, Ronald C. Petersen, John C. Morris
3: Neuropsychiatric Symptoms, Jeffrey L. Cummings
4: Normative Neuropsychology in Aging and Mild Cognitive Impairment, Glenn E. Smith, Robert J. Ivnik
5: Optimizing Cognitive Test Norms for Detecting Mild Cognitive Impairment, Martin Sliwinski, Richard Lipton, Herman Buschke, Christina Wasylyshyn
6: Magnetic Resonance Imaging, Clifford R. Jack, Jr.
7: Functional Imaging, Marilyn S. Albert, Keith A. Johnson
8: Spectrum of Pathology from Normal Function to Mild Cognitive Impairment, Heiko Braak, Eva Braak
9: Role of Entorhinal Cortext and Superior Temporal Sulcus, Bradley T. Hyman, Teresa Gomez-Isla
10: Biological Markers, Neill R. Graff-Radford, Steven G. Younkin
11: Clinical Evaluation, Ronald C. Petersen
12: Treatment of Mild Cognitive Impairment and Prevention of Alzheimer's Disease, David S. Knopman
Review :
"Mild Cognitive Impairment should be of considerable interest to both community and academic neurologists as well as geriatricians and geriatric psychiatrists. Petersen has assembled a strong set of writers to cover all aspects of the MCI question." -Howard Chertkow, M.D., Canada.
". . . a broad and encompassing resource . . . the chapters are stellar in their readability and informative nature . . . well written, well organized, and well referenced." --JINS
"The chapters in this very interesting book address the range of issues that identify this area of inquiry: clinical studies, cognitive tests, magnetic resonance imaging (MRI), neuropathological changes, biological markers, and clinical evaluation...For those who work with geriatric patients, this is a very interesting volume. As a clinician, I found it very instructive."--American Journal of Psychiatry
"This is a well-written, authoritative, multiauthored book on the emerging concept of minimal cognitive impairment. Not only is it readable, but it reflects current state-of-the-art thinking about this concept that is in transition. Experts on dementia will want to have a copy of this book."--Doody's
". . . an excellent introductory and/or review book for clinicians and researchers . . . a 'must have' book for your library." --The Clinical Neuropsychologist
"...I highly recommend this book for anyone involved in clinical or research activities in AD and MCI. Petersen has put together the most comprehensive review of this topic available. Given the predicted future growth in prevalence of MCI and AD, the topics covered in this book will become increasingly salient..." --Archives of Neurology
"an interesting, thought-provoking, sometimes controversial and eminently readable book...a comprehensive and highly accessible account of current thinking about MCI, which will be useful for clinicians and researchers who are interested in ageing and dementia...a valuable resource."--J.S. Snowden in BRAIN
"...this book offers a useful summary of the relevant research across topics and issues pertaining to the concept of MCI."--Applied Neuropsychology
"Mild Cognitive Impairment should be of considerable interest to both community and academic neurologists as well as geriatricians and geriatric psychiatrists. Petersen has assembled a strong set of writers to cover all aspects of the MCI question." -Howard Chertkow, M.D., Canada.
"The chapters in this very interesting book address the range of issues that identify this area of inquiry: clinical studies, cognitive tests, magnetic resonance imaging (MRI), neuropathological changes, biological markers, and clinical evaluation...For those who work with geriatric patients, this is a very interesting volume. As a clinician, I found it very instructive."--American Journal of Psychiatry
". . . a broad and encompassing resource . . . the chapters are stellar in their readability and informative nature . . . well written, well organized, and well referenced." --JINS
"This is a well-written, authoritative, multiauthored book on the emerging concept of minimal cognitive impairment. Not only is it readable, but it reflects current state-of-the-art thinking about this concept that is in transition. Experts on dementia will want to have a copy of this book."--Doody's
"an interesting, thought-provoking, sometimes controversial and eminently readable book...a comprehensive and highly accessible account of current thinking about MCI, which will be useful for clinicians and researchers who are interested in ageing and dementia...a valuable resource."--J.S. Snowden in BRAIN
"...this book offers a useful summary of the relevant research across topics and issues pertaining to the concept of MCI."--Applied Neuropsychology
