Presynaptic Inhibition and Neural Control

This is a timely review of the mechanisms underlying the presynaptic control of synaptic transmission and the role they play in sensory and motor behavior. Early chapters offer a detailed account of the anatomy, biophysics, and physiology of synaptic transmission at the peripheral and central synapses, focusing on the presynaptic control of transmitter release. Later chapters explore the organization of neural pathways leading to the presynaptic inhibition of transmitter release in segmental reflex pathways. A final section provides examples of the operation of presynaptic control mechanisms during specific sensory and motor functions in mammals, including humans. Integrating synaptic transmission and CNS functions at the systems level, this volume will be of particular interest to researchers studying both areas.

Table of Contents:
I. Basic Mechanisms of Presynaptic Control 1: F.J. Alvarez (Wright State University): Anatomical Basis for Presynaptic Inhibition on Primary Sensory Fibers 2: F.J. Alvarez-Leefmans and Andrés Nani (Instituto Mexicano de Psiquiatría, México), Sergio Márquez (University of Texas Medical Branch): Chloride Transport, Osmotic Balance and Presynaptic Inhibition 3: K. Dunlap (Tufts University School of Medicine): Mechanisms and Physiological Implications of Receptor-Mediated Inhibition of Voltage-Dependent Ca2+ Channels 4: S.M. Thompson (University of Zurich, Switzerland), M. Capogna and M. Scanziani (University of California, San Francisco): Presynaptic Inhibition and Facilitation of Transmitter Release 5: L. Vyklicky and H. Urbancová (Academy of Science of Czech Republic): Primary Afferent Depolarization and Presynaptic Inhibition 6: H.R. Lüscher (University of Bern, Switzerland): Control of Action Potential Invasion into Terminal Arborizations 7: B. Walmsley and M.J. Nicol (University of Newcastle, Australia): Action Potential Propagation Along Primary Afferents and Presynaptic Inhibition in Clarkes's Column of the Spinal Cord 8: D.R. Curtis (John Curtin School of Medical Research, Australia): Two Types of Inhibition in the Spinal Cord 9: S.J. Redman (John Curtain School of Medical Research, Australia): The Relative Contributions of GABAA and GABAB Receptors to Presynaptic Inhibition of Group Ia EPSPs 10: H. Hultborn (University of Copenhagen, Denmark) and J. Nielsen (Christian-Albrechts-Universitat zu Kiel, Germany): Modulation of Transmitter Release From Ia Afferents by Their Preceding Activity- A 'Post-activation Depression' 11: D. Cattaert and F. Clarac (Laboratoire Neurobiologie et Mouvement, Marseille): Presynaptic Inhibition of Neuromuscular Transmission in Crayfish 12: D.S. Faber and A. Pereda (Medical College of Pennsylvania and Hahnemann University): Regulation of Primary Eighth Nerve Synapses on the Mauthner Cell 13: P.D. Wall (UMDS, St. Thomas' Campus, London): Some Unanswered Questions About the Mechanisms and Function of Presynaptic Inhibition II. Presynaptic Control of Segmental Inputs 14: R.E. Burke (National Institutes of Health, Bethesda): Presynaptic Inhibition and the Anatomy of Group Ia Afferents 15: L.M. Mendell (SUNY, Stony Brook): Ia Fiber Architecture: Implications for the Functional Role of Presynaptic Inhibition 16: A. Lev-Tov (The Hebrew University Medical School, Jerusalem): Dynamic Aspects of Presynaptic Function in the Developing Mammalian Spinal Cord 17: P. Rudomin , I. Jiménez. and J. Quevedo (Centro de Investigación y de Estudios Avazados del Institito Politécnico Nacional, México): Selectivity of the Presynaptic Control of Synaptic Effectiveness of Group I Afferents in the Mammalian Spinal Cord 18: D. Zynicki and L. Jami (Univesité René Descartes, Paris): Presynaptic Inhibition Can Act as a Filter of Input from Tendon Organs during Muscle Contraction 19: E. Jankowska (Goteborg University, Sweden) and J.S. Riddell (University of Glasgow): Neuronal Systems Involved in Modulation Synaptic Transmission from Group II Muscle Afferents 20: A. El Manira, D. Parker et al. (Karolinska Institute, Sweden): Presynaptic Inhibition of Synaptic Transmission from Sensory, Interneuronal and Supraspinal Neurons to Spinal Target Cells in Lamprey III. Contribution of Presynaptic Control Mechanisms to Sensory and Motor function 21: E. Pierrot-Deseilligny and S. Meunier (Hôpital de la Salpétière, Paris): Differential Control of Presynaptic Inhibition of Ia Terminals during Voluntary Movement in Humans 22: D. McCrea and M.C. Perrault (University of Manitoba, Canada): PAD and Modulation of Evoked Group II Flexion Reflexes during MLR-Evoked Fictive Locomotion 23: S. Rossignol, I. Beloozerova, J.P. Gossard, and R. Dubuc (Université de Montréal, Canada): Presynaptic Mechanisms during Locomotion 24: S.J. Shefchyk (University of Manitoba, Canada): Modulation of Excitatory Perineal Reflexes and Sacral Striated Sphincter Motoneuron during Micturition in the Cat 25: W.D. Willis, K.A. Sluka, H. Rees, and K.N. Westlund (University of Texas): A Contribution of Dorsal Root Reflexes to Peripheral Inflammation 26: R.F. Schmidt and H.G. Schaible (Physiologisches Institut der Universitat, Würzberg): Modulation of Nociceptive Information at the Presynaptic Terminals of Primary Afferent Fibers Bibliography Index

Review :
"...this scholarly and rigorous treatise of presynaptic inhibition will prove valuable to anyone exploring the depths of synaptic integration."--The Quarterly Review of Biology "Overall, this book is well-written and nicely produced. The list of authors is impressive and certainly represents leaders in the field. The editors have also done a good job in achieving a relatively uniform style among the different chapters and the cross-references between the different chapters are quite helpful." - Dr. Robert Chen, The Canadian Journal of Neurological Sciences