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The Cortical Neuron

The Cortical Neuron


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About the Book

To understand how the cerebral cortex functions requires knowledge of single cells in this region and of their organization into cortical networks. Looking beyond the classical "wiring diagram" description of the organization of cortical cells into circuits, this innovative work focuses on dynamic aspects of cerebral cortical physiology, both at the single-neuron and network levels. Recent years have seen a remarkable expansion of knowledge about the basic cellular physiology and molecular biology of cortical neurons--their membrane properties, their synaptic characteristics, their functional connectivity, their development, and the mechanisms of their response to injury. This authoritative volume includes contributions by many of the renowned neurobiologists and neurologists directly responsible for these advances. It is divided into four main sections, each of which is prefaced with an overview by a leading expert in the field. The sections cover cortical neurons and synapses, the cortical network, the developing cortical neuron, and the vulnerable cortical neuron. This final section focuses on the cortical neuron in relation to the mechanisms of epilepsy. Together, the chapters provide a balanced, up-to-date, multidisciplinary perspective on the normal and pathological function of the cells of the cerebral cortex, identifying the controversies and critical issues facing modern researchers in this exciting field.

Table of Contents:
Part I: General Overview 1: D.A. Prince: Thirty Years Among Cortical Neurons Part II: A Cellular and Synaptic Perspective of the Cortical Neuron 2: C.F. Stevens: Cortical Synaptic Transmission: An Overview 3: M.J. Gutnick and W.E. Crill: The Cortical Neuron as an Electrophysiological Unit 4: H. Schulman: Signal Transduction and Protein Phosphorylation 5: R.J. Dingledine and J.A. Bennett: Structure and Function of Ligand-Gated Channels 6: S. Thompson, D.V. Madison and I. Mody: Synaptic Actions of Amino Acid Neurotransmitters 7: R.C. Malenka: Synaptic Plasticity in Hippocampus and Neocortex: A Comparison Part III: The Cortical Neuron as Part of a Network 8: E.G. Jones: Overview: Basic Elements of the Cortical Network 9: B.W. Connors and J. Amitai: Functions of Local Circuits in Neocortex: Synchrony and Laminae 10: L.S. Benardo and R.K.S. Wong: Inhibition in the Cortical Network 11: J.R. Huguenard, D.A. McCormic and D. Coulter: Thalamocortical Interactions 12: P.C. Bush and T.J. Sejnowski: Models of Cortical Networks Part IV: The Developing Cortical Neuron 13: A.R. Kriegstein: Determination of Cellular Phenotype and the Fundamental Organization of Cortical Layering: An Overview 14: J. LoTurco and A.R. Kriegstein: Neurotransmitter Signaling Befor the Birth of Neurons 15: J. Noebels: Gene Control of Cortical Excitability 16: R.A. Deisz and H. Luhmann: Development of Cortical Excitation and Inhibition 17: P. Kellaway: Cortical Epileptogenesis in the Developing Human Brain Part V: The Vulnerable Cortical Neuron 18: D.W. Choi: Glutamate Receptors and Neuronal Death: A Beginning 19: J.E. Kraus and J.O. McNamara: Measurement of Cortical Neurotransmitter Receptors with Radioligand Binding: Insights into the Mechanisms of Kindling-Induced Epilepsy 20: P.A. Schwartzkroin: Pathophysiology of Cortical Synapses and Circuits 21: L.M. Masukawa: Pathophysiology of Cortical Areas from Human Epileptics 22: G.W. Albers: Clinical Strategies for Neuronal Protection

Review :
"A valuable "snapshot" of various aspects of neuroscience research related to cortical neurons."--Science "Well integrated and organized and has a clarity of writing style across chapters indicative of an excellent editing effort....This excellent volume...can profit laboratory scientists as well as clinicians."--Neurological Research "A valuable "snapshot" of various aspects of neuroscience research related to cortical neurons."--Science "Well integrated and organized and has a clarity of writing style across chapters indicative of an excellent editing effort....This excellent volume...can profit laboratory scientists as well as clinicians."--Neurological Research


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Product Details
  • ISBN-13: 9780195083309
  • Publisher: Oxford University Press Inc
  • Publisher Imprint: Oxford University Press Inc
  • Height: 244 mm
  • No of Pages: 424
  • Weight: 963 gr
  • ISBN-10: 019508330X
  • Publisher Date: 12 Oct 1995
  • Binding: Hardback
  • Language: English
  • Spine Width: 30 mm
  • Width: 171 mm


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