Translational Gastroenterology
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Translational Gastroenterology: (Handbook for Designing and Conducting Clinical and Translational Research)

Translational Gastroenterology: (Handbook for Designing and Conducting Clinical and Translational Research)

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About the Book

Translational Gastroenterology covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. Readers will learn important concepts, including case-control study, prospective cohort study, randomized trials, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in gastroenterology, and know what is needed in collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in gastroenterology, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every medical researcher or gastroenterologist who has ever had a good clinical idea but not the knowledge of how to test it.

Table of Contents:
PART I: CONCEPT 1. Introduction to clinical research 2. The question 3. Study population 4. Outcome measurements PART II: STUDY TYPES 5. Design principles 6. Case series 7. Case-control study 8. Cohort study 9. Cross-section study 10. Clinical trials 11. Meta-analysis 12. Cost-effectiveness study 13. Diagnostic test evaluation 14. Reliability study 15. Database studies 16. Surveys and questionnaires 17. Qualitative methods and mixed methods Definition of the study type PART III: CLINICAL TRIALS 17. Randomized control 18. Nonrandomized control 19. Historical control 20. Cross-over 21. Withdrawal studies 22. Factorial design 23. Group allocation 24. Hybrid design 25. Large, pragmatic 26. Equivalence and noninferiority 27. Adaptive 28. Randomization 30. Multicenter considerations Study design and practical considerations PART IV: PLANNING 31. Optimizing the question 32. Meaningful outcome measurements  33. Sample size Power analysis 34. Budgeting Funding, timeline, personnel, materials 35. Ethics and review boards  36. Regulatory considerations for new drugs and devices  37. Funding approaches  38. Research team  39. Subject recruitment  40. Data management  41. Quality control  42. Report forms 43. Subject adherence  44. Survival analysis  45. Monitoring committee in clinical trials PART V: STATISTICAL PRINCIPLES 46. Presenting data  47. Common issues in analysis  48. Basic statistical principles  49. Distributions Description, examples, implications in analysis. 50. Hypotheses and error types  51. Power Detecting effects 52. Regression Explanation 53. t-test Explanation 54. Chi-square Explanation 55. Analysis of variance Explanation 56. Correlation Explanation 57. Biases 


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Product Details
  • ISBN-13: 9780128214268
  • Publisher: Elsevier Science Publishing Co Inc
  • Publisher Imprint: Academic Press Inc
  • Height: 276 mm
  • No of Pages: 516
  • Weight: 450 gr
  • ISBN-10: 0128214260
  • Publisher Date: 30 May 2025
  • Binding: Paperback
  • Language: English
  • Series Title: Handbook for Designing and Conducting Clinical and Translational Research
  • Width: 216 mm


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Translational Gastroenterology: (Handbook for Designing and Conducting Clinical and Translational Research)
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Translational Gastroenterology: (Handbook for Designing and Conducting Clinical and Translational Research)
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