Proteomic and Metabolomic Approaches to Biomarker Discovery
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Proteomic and Metabolomic Approaches to Biomarker Discovery

Proteomic and Metabolomic Approaches to Biomarker Discovery


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About the Book

Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research.

Table of Contents:
1. Biomarker discovery: Study design and execution 2. Proteomic and mass spectrometry technologies for biomarker discovery 3. Tissue sample preparation for proteomic analysis 4. Sample preparation in global metabolomics of biological fluids and tissues 5. Serum and plasma collection: Preanalytical variables and standard operating procedures in biomarker research 6. Sample depletion, fractionation, and enrichment for biomarker discovery 7. Current NMR strategies for biomarker 8. Gas chromatography/mass spectrometrybased metabonomics 9. Liquid chromatographic methods combined with mass spectrometry in metabolomics 10. Capillary electrophoresis-mass spectrometry for proteomic and metabolic 11. Associating 2-DE and CPLLs for low-abundance protein discovery: A winning strategy 12. Two-dimensional difference in gel electrophoresis for biomarker discovery 13. Affinity-targeting schemes for protein biomarkers 14. Protein and metabolite identification 15. Quantitative proteomics in development of disease protein biomarkers 16. Mass spectrometry and NMR spectroscopy based quantitative metabolomics 17. Top-down mass spectrometry for protein molecular diagnostics, structure analysis, and biomarker discovery 18. Using data-independent mass spectrometry to extend detectable dynamic range without prior fractionation 19. Imaging mass spectrometry of intact biomolecules in tissue section 20. Mass spectrometry-based approach for protein biomarker verification 21. Mass spectrometry metabolomic data handling for biomarker discovery 22. Analytical methods and biomarker validation 23. Multivariate analysis for metabolomics and proteomics data 24. Cell surface protein enrichment for biomarker and drug target discovery using mass spectrometry-based proteomic 25. Advances in lipidomics for cancer biomarker discovery 26. Mass spectrometry for the identification of protein biomarkers in urinary extracellular vesicles 27. Designing clinical studies for biomarker discovery: The DESIGN criteria

About the Author :
Haleem J. Issaq received his B.S. degree from the American College of Istanbul, Turkey, a M.S. degree from the Technion, Israel Institute of Technology, and a Ph.D. in analytical chemistry from Georgetown University in 1972. He was a Principal Scientist and Head of the Separation Technologies and Assay Development Group within the Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc., located within the National Cancer Institute at Frederick, Maryland. His research interests include multidimensional separation of complex protein/peptide mixtures using liquid-phase-based separations (LC/LC, IEF/LC, and LC/CE), fast separation of estrogens, and use of HPLC/MS metabolomics for disease biomarker detection. He is the author or coauthor of over 350 scientific publications and the editor of A Century of Separation Science. He is the recipient of numerous awards, including Maryland Chemist of the Year. Dr. Timothy Veenstra obtained his PhD in Biochemistry from University of Windsor (Windsor, ON) and completed a three-year post-doctoral fellowship at the Mayo Clinic under the guidance of Dr. Rajiv Kumar. He has over 20 years of research experience both in academics and as a Senior Vice President for a biotech company that focused on neurological diseases. With more than 380 published works (including 2 books), and eight patents, Dr. Timothy Veenstra brings a wealth of knowledge and experience to share with Maranatha’s science students.


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Product Details
  • ISBN-13: 9780128186077
  • Publisher: Elsevier Science Publishing Co Inc
  • Publisher Imprint: Academic Press Inc
  • Height: 235 mm
  • No of Pages: 504
  • Width: 191 mm
  • ISBN-10: 0128186070
  • Publisher Date: 29 Oct 2019
  • Binding: Paperback
  • Language: English
  • Weight: 1000 gr


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