Handbook of Vascular Motion

Handbook of Vascular Motion provides a comprehensive review of the strategies and methods to quantify vascular motion and deformations relevant for cardiovascular device design and mechanical durability evaluation. It also explains the current state of knowledge of vascular beds that are particularly important for the medical device industry. Finally, it explores the application of vascular motion to computational simulations, benchtop testing and fatigue analysis, as well as further implications on clinical outcomes, product development and business.

Table of Contents:
1. Introduction Part I Methods for Quantifying Vascular Deformations2. Deciding What You Need and How to Get It3. Medical Imaging Modalities and Protocols4. Geometric Modeling5. Centerline Deformation Metrics6. Surface Deformation Metrics Part II Deformations of Vascular Beds Relevant for Medical Devices7. Coronary Blood Vessels8. Neurovascular Blood Vessels9. Thoracic Aorta and Arch Branches10. Abdominal Aorta and Visceral Arteries11. Lower Extremity Arteries12. Inferior Vena Cava and Lower Extremity Veins13. Upper Extremity Blood Vessels Part III Developing and Utilizing Boundary Conditions14. Developing Boundary Conditions for Durability Evaluation15. Summary of Durability Evaluation Methods16. How to Improve Durability in a Pinch17. Areas of Future Research18. Conclusions

About the Author :
Dr. Christopher Cheng has over 20 years of experience in academic research and the medical device industry. His academic research has focused on hemodynamics and vascular structure mechanics, with an emphasis on disease research and medical device interactions with the body. He has authored over 80 journal, conference, and book chapter publications. In his industry experience, Dr. Cheng has worked at small and large medical device companies, with experience spanning design, manufacturing, preclinical testing, clinical trials, and marketing. Currently, Dr. Cheng is CEO of Koli, Inc., an early-stage medical device company developing a catheter-based solution for gallstone disease. Dr. Cheng is also an Adjunct Professor in the Division of Vascular Surgery at Stanford, where he runs the Vascular Intervention Biomechanics & Engineering (VIBE) lab. Dr. Cheng earned his undergraduate degree in Biomedical Engineering and Electrical & Computer Engineering at Duke University. He then earned Master’s and Ph.D. degrees in Biomechanics at Stanford University.

Review :
"It’s exciting when a new field opens up -- and that’s where we are with vascular motion. Dr. Cheng has provided a clear and highly readable overview of the medical and engineering science surrounding the motion of vessels and the consequences for treatments and technologies. As a bonus, the book is sprinkled with some intriguing hints of new things to come as clinicians, investigators, and inventors pursue this rapidly evolving area." --Paul G. Yock – Interventional Cardiologist, Martha Meier Weiland Professor of Medicine, Professor of Bioengineering and Mechanical Engineering (by courtesy), & Director of Byers Center for Biodesign, Stanford University, Stanford, CA "This first of its kind textbook deals with topics that will gain increasing importance as endovascular grafts are increasingly used to treat vascular lesions. These endografts have to dwell and function in a hostile vascular environment governed by some of the forces described in this unique text. Overcoming these forces is a key challenge for the future. This book will help meet that challenge." --Frank J. Veith – Vascular Surgeon, Professor of Surgery, New York University, New York, NY and Director of VEITHsymposium "Handbook of Vascular Motion is destined to be a ‘must-read’ for all those interested in the human vascular system. From anatomists to physiologists, vascular clinicians to sports medicine practitioners, biomedical engineers to medical device entrepreneurs, all will find that this special volume provides enlightening evidence of how data-driven insights have dramatically enhanced our understanding of vascular motion and its impact on normal function, development of vascular disease, and design of durable vascular implants. Indeed, Professor Cheng's superb text tackles a previously unaddressed need in an increasingly relevant field of study by focusing on how motion in a wide range of vascular beds impacts the design and performance of medical devices. It is the first comprehensive source to provide a well-organized presentation of the important considerations, including previously unpublished scientific and computational data that underpin the influential effects of vascular motion in humans." --Michael D. Dake – Interventional Radiologist, Senior Vice President of University of Arizona Health Sciences & Professor of Medical Imaging, Surgery, and Medicine, University of Arizona, Tuscon, AZ "I very much enjoyed reading this book which provides a wealth of information on the complex and dynamic movement of blood vessels and how this motion can affect the effectiveness and durability of intravascular devices used to treat cardiovascular disease. We have witnessed remarkable advances in the sophistication and effectiveness of implanted medical devices used to treat cardiovascular disease, which is the number one cause of death and disability in the world. However, our understanding of the biomechanical forces acting on these devices as a result of the complex, dynamic movement of blood vessels in everyday life is limited. This is the first book to bring together the large body of scientific information on the movement of blood vessels to show how this motion can impact the durability and function of implanted devices. This book is a must read and reference source for physicians, scientists, biomedical engineers, medical device developers, safety engineers, and regulators who have an interest in improving the treatment of cardiovascular disease." --Christopher K. Zarins – Vascular Surgeon, Emeritus Professor of Surgery, Stanford University, Stanford, CA & Co-Founder and Senior VP of Medical Affairs, HeartFlow, Inc., Redwood City, CA