Brain Imaging Using PET

Discussing not only PET technique and instrumentation, but new developments in a broad range of fields such as kinetics, enzyme/neurotransmitter transport, language acquisition, and neuropathology, Brain Imaging Using PET will appeal to both PET experts and non-PET users in many branches of neuroscience. The authors offer an invaluable analysis of brain imaging and techniques, providing everything from the foundations to the practical applications of the modern techniques used in PET.

Table of Contents:
Contributors Preface Acknowledgments Part I Instrumentation 1. Correction of Head Movement Using an Optical Motion Tracking System during PET Study with Rhesus Monkey I. Introduction II. Materials and Methods III Results and Discussion 2. The Effect of Activity from Outside the Field of View on Accurate Quantification of 3D PET Images I. Introduction II. Materials and Methods III. Results IV. Discussion V. Conclusion 3. Delay and Dispersion Correction for a New Coincidential Radioactivity Detector, Pico-Count, in Quantitative PET Studies I. Introduction II. Materials and Methods III. Results and Discussion Part II Kinetic Analysis 4. Neuroreceptor Imaging: Considerations for Design, Data Analysis, and Interpretation I. Introduction II. Radioligand III. Is Quantification Needed? IV. Image Fusion V. Experimental Design VI. Clinical Use of Neuroreceptor Imaging 5. Quantification of µ-Opioid Receptor Binding with [11C]Carfentanil: Evaluation of Reference-Tissue Approaches I. Introduction II. Materials and Methods III. Results IV. Discussion V. Conclusion 6. A New Linear Parametric Imaging Algorithm Derived from a Simplified Reference Tissue Model for Ligand-Receptor Dynamic PET Studies I. Introduction II. Materials and Methods III. Results and Discussion 7. PET Functional Parametric Images of Acetylcholine Esterase Activity without Blood Sampling I. Introduction II. Materials and Methods III. Results IV. Discussion 8. Reference-Tissue-Based Kinetic Analysis of [11C]MP4A PET Data without Arterial Input I. Introduction II. Materials and Methods III. Results and Discussion 9. Pixel-by-Pixel Mapping of Acetylcholinesterase Activity in Human Brain with [11C]MP4A/PET I. Introduction II. Materials and Methods III. Results and Discussion 10. Scatchard Analysis with Bolus/Infusion Administration of [11C]Raclopride: Amphetamine Effects in Anesthetized Monkeys I. Introduction II. Methods III. Results IV. Discussion 11. Comparison between Bolus and Infusion [11C]Raclopride Delivery for the Quantification of Dopamine Release I. Introduction II. Materials and Methods III. Results IV. Discussion 12. Bolus Infusion of [11C]Raclopride: Whole Body Kinetics and Tissue Uptake Error Estimates in Primate I. Introduction II. Materials and Methods III. Results IV. Discussion 13. Computationally Efficient Algorithms for Determining Weighted Average and Gray Matter Cerebral Blood Flow in Heterogeneous Tissues by Positron Emission Tomography I. Introduction II. Theory III. Simulation Studies IV. Results I. Discussion 14. Bayesian Estimation of Kinetic Rate Constants Using PET and Compartmental Models I. Introduction II. Materials and Methods III. Results and Discussion 15. Wavelet Methods for the Mathematical and Statistical Modeling of PET Images I. Introduction II. Methodology III. Results IV. Discussion 16. Use of MM Algorithm for Regularization of Parametric Images in Dynamic PET I. Introduction II. Theory III. Methods IV. Results V. Discussion VI. Conclusion 17. Tracer Kinetic Modeling via Basis Pursuit I. Introduction II. Materials and Methods III. Results and Discussion Part III Image Analysis 18. Measurement of Partial Volume Effect in the Ventral Striatum Using [11C]Raclopride I. Introduction II. Methods III. Results IV. Discussion V. Conclusion 19. Volume-of-Interest-Based Automated Partial Volume Correction for Large Numbers of PET Data Sets I. Introduction II. Subjects Methods III. Results IV. Discussion V. Conclusion VI. Appendix 20. Parametric Definition of ROIs to Recover the Caliber of Cerebral Blood Vessels Directly from PET Images I. Introduction II. Materials and Methods III. Results IV. Discussion V. Conclusion 21. A New Method of Selectively Analyzing Gray- or White-Matter Uptake in Brain PET Images I. Introduction II. Materials and Methods III. Results IV. Discussion 22. Partial Volume Correction of Simulated PET and 18F FDG PET from 14 Normal Brains I. Introduction II. Materials and Methods III. Results IV. Discussion 23. A Simple Approach to Combined Inhomogenity Correction and Tissue Segmentation of MR MPRAGE Images I. Introduction II. Materials and Methods III. Results IV. Conclusion V. Further Development 24. Improved Lesion Localization in PET Using Cluster Analysis I. Introduction II. Materials and Methods III. Results IV. Discussion V. Conclusion 25. Brain Tissue Clustering Based on Parametric Analysis I. Introduction II. Materials and Methods III. Results IV. Discussion V. Conclusion 26. Methodological Aspects of [18F]FDG Regional Metabolic Covariance Pattern Comparisons in a Longitudinal PD Clinical Study I. Introduction II. Methods III. Results IV. Discussion 27. Is a FDG Template Applicable to Standardization of CBF Images in a 3D SSP System? I. Introduction II. Materials and Methods III. Results IV. Discussion 28. Comparison of FDG Normal Brain Images among Three PET Centers I. Background and Purpose II. Methods III. Results IV. Discussion V. Conclusion 29. An MR-Based Statistical Volumetric Atlas of the Brain of Göttingen Miniature Pigs I. Introduction II. Materials and Methods III. Results IV. Discussion 30. Shortening rCBF Measurement Interval in [15O] H2O PET I. Introduction II. Materials and Methods III. Results IV. Discussion Part IV Tracers and Basic Neuroscience 31. Animal PET for Brain Research From Receptor Binding to Second Messenger System I. Introduction II. Materials and Methods III. Results 32. NK1 Receptor Occupancy in the Monkey Brain Studied by [11C]GR205171 I. Introduction II. Materials and Methods III. Results IV. Discussion 33. Restoration of [18F]Fluorodopa Uptake in Brain of MPTP-Intoxicated Pigs with Fetal Mesencephalic Neuron Grafts I. Introduction II. Materials and Methods III. Results IV. Discussion V. Conclusion 34. Mapping of Carbonic Anhydrase and Estrone Sulfatase in Rat Brain using 16a-[18F]Fluoroestradiol-3,17ß-disulfamate ([18F]FESDS) I. Introduction II. Methods III. Results IV. Discussion 35. In Vivo FWIN Uptake Correlates with In Vitro Measurements of the Dopamine Reuptake Transporter following MPTP Lesioning I. Introduction II. Materials and Methods III. Results and Discussion 36. Mapping of the Sigma1 Receptors in the Primate Brain by PET with [11C]SA4503 I. Introduction II. Materials and Methods III. Results and Discussion Part V Clinical Neuroscience and Mapping 37. Thalamic Stimulation for Parkinsonian Tremor: Correlation between Regional Cerebral Blood Flow and Biodynamic Tremor Characteristics I. Introduction II. Materials and Methods III. Results IV. Discussion 38. Brain Regions Involved in Learning Face-Name Associations and the Effects of Agem Performance, and Learning Phase I. Introduction II. Subjects and Methods III. Results IV. Discussion 39. Development of a PET System for Cognitive Activation Studies in Conscious Monkeys I. Introduction II. Materials and Methods III. Results and Discussion IV. Conclusion 40. Detection of Stage II Compromised Cerebrovascular Reserve by Xenon-CT Cerebral Blood Flow with Acetazolamide and Oxygen Extraction Fraction by Positron Emission Tomography I. Introduction II. Subjects and Methods III. Results IV. Discussion 41. Brain Mapping of Muscle-Brain Interaction during Chewing by SPM Analysis: A FDG-PET Study I. Introduction II. Methods III. Results IV. Discussion 42. Comparison of Mapping Parameters in [18F]FPCIT Imaging of Early Stage Parkinson's Disease I. Introduction II. Materials and Methods III. Results IV. Discussion V. Conclusion 43. Comparative Analysis of Striatal FDOPA Uptake in Parkinson's Disease: SOR versus K1 I. Introduction II. Materials and Methods III. Results and Discussion IV. Summary 44. Patterns of Distribution of [18F]6-Fluoro-L-rn-Tyrosine in PET Images of Patients with Movement Disorders I. Introduction II. Materials and Methods III. Results IV. Discussion V. Conclusion 45. Comparison of Regional Cerebral Blood Flow Values between Xenon-133 and O-15 H2O PET Parametric Images I. Introduction II. Methods III. Results and Discussion 46. Clinical Evaluation of a New Noninvasive Regional Cerebral Blood Flow Measurement Technique Using the Brain Uptake Ratio of 99mTc-ECD I. Introduction II. Materials and Methods III. Results and Discussion 47. Statistical Mapping of the Brain Stem Using [18F]FDOPA PET Images: A Basic Study I. Introduction II. Methods III. Results and Discussion IV. Conclusion