Cyclic AMP

Cyclic AMP provides information pertinent to cyclic adenosine 3',5'-monophosphate (AMP), a regulatory agent that controls the rate of a number of cellular processes. This book discusses the heat-stable factor mediating the action of glucagon and epinephrine on the activation of liver phosphorylase. Organized into 12 chapters, this book starts with an overview of the biological role of cyclic AMP, which is extended from a relatively simple role in liver glycogenolysis to a significant regulatory agent in most mammalian tissues. This text then discusses the development that led to the discovery of the heat-stable factor from investigations with cyclic nucleotides. Other chapters explore the chemical agents, which are released from one group of cells and travel via the bloodstream to affect one or more different groups of cells. The final chapter discusses the role of cyclic AMP to mammalian physiology, with emphasis on the many possible defects that may lead to human disease. This book is a valuable resource for graduate students and clinical investigators involved in biological and biomedical sciences.

Table of Contents:
Preface Chapter 1. An Introduction I. Glycogenolysis II. Activation of Phosphorylase III. Chemical Nature of Phosphorylase Activation IV. The Identification of Cyclic AMP Chapter 2. Cyclic AMP and Hormone Action I. Introduction II. Hormones III. Receptors and Second Messengers IV. The Intracellular Level of Cyclic AMP V. Experimental Approaches Used in the Study of Hormones which Stimulate Adenyl Cyclase VI. Two Major Problems VII. Addendum Chapter 3. Chemistry of Cyclic Nucleoside Phosphates and Synthesis of Analogs I. Chemistry of Cyclic Nucleoside Phosphates II. Derivatives of Cyclic AMP III. Recent Progress Chapter 4. Formation and Metabolism of Cyclic AMP I. Adenyl Cyclase II. Phosphodiesterase III. Addendum Chapter 5. Some Actions of Cyclic AMP I. Introduction II. Effects of Exogenously Administered Cyclic AMP III. Effects on Enzymes IV. Effects on Protein Synthesis V. Other Effects of Cyclic AMP VI. Addendum Chapter 6. The Catecholamines I. Introduction II. Adrenergic Receptors III. Effects on Carbohydrate Metabolism IV. The Calorigenic Effect V. Some Other Metabolic Effects VI. Some Functional Effects of Adrenergic Stimulation VII. Other Factors Influencing Adrenergic Responses Involving Cyclic AMP VIII. General Considerations and Summary IX. Addendum Chapter 7. Glucagon and Insulin I. Introduction II. Glucagon III. Insulin IV. Addendum Chapter 8. Lipolysis in Adipose Tissue I. Introduction II. The Role of Cyclic AMP in the Actions of Lipolytic Hormones III. Agents which Decrease Cyclic AMP Levels and Lipolysis in Adipose Tissue IV. Phosphodiesterase Inhibitors V. Other Factors Controlling Lipolysis which May Involve Cyclic AMP Directly or Indirectly VI. Summary VII. Addendum Chapter 9. Cyclic AMP and Steroidogenesis I. Introduction II. The Adrenal Cortex III. Cyclic AMP and Steroidogenesis in the Gonads IV. Summary V. Addendum Chapter 10. Other Hormones I. Vasopressin II. Thyroid Stimulating Hormone III. MSH and Melatonin IV. Hormones Regulating Calcium Homeostasis V. Gastrointestinal Hormones VI. Histamine VII. Serotonin VIII. Acetylcholine IX. The Prostaglandins X. Hypothalamic Releasing Hormones XI. Thyroid Hormone XII. Steroid Hormones XIII. Growth Hormone XIV. Some Bacterial and Plant Products XV. Summary Chapter 11. Other Cyclic Nucleotides I. Introduction 11. Methods of Detection III. Cyclic GMP in Tissues IV. Guanyl Cyclase V. Hydrolysis of Cyclic GMP by Cyclic Nucleotide Phosphodiesterase(s) VI. Effects of Cyclic GMP VII. Cyclic GMP and Cyclic AMP in Urine VIII. Summary IX. Addendum Chapter 12. Cyclic AMP in Lower Organisms I. Introduction II. Bacteria III. Cellular Slime Molds IV. Cancer V. Other Organisms VI. Concluding Remarks Appendix References Subject Index