Proteolysis and Physiological Regulation

Miami Winter Symposia, Volume 11: Proteolysis and Physiological Regulation contains the proceedings of the University of Miami's Biochemistry Department Symposium on "Proteolysis and Physiological Regulation", which is published simultaneously with the proceedings of the Papanicolaou Cancer Research Institute's Symposium on "Cancer Enzymology" (Volume 12). This volume is composed of 35 chapters and begins with surveys of the structural properties and role of various enzymes in biological regulation. The subsequent chapters describe the structure-activity relationship, cellular production, selectivity, mechanisms, and substrate specificity of the enzymes. Other chapters explore the activation, regulation, biosynthesis, and other biological activities of other enzymes. The remaining chapters discuss property modification, metabolism, binding, and other biological aspects of enzymes. This book will prove useful to enzyme scientists, cell biologists, biochemists, and researchers.

Table of Contents:
Speakers, Chairmen, and Discussants Preface The Seventh Feodor Lynen Lecture My Life with Proteins and Their Prosthetic Groups The Role of Proteases in Biological Regulation Structural Studies on the Pancreatic Trypsin Inhibitor-Trypsin Complex and Its Free Components: Structure and Function Relationship in Serine Protease Inhibition and Catalysis The Proteolytic Enzymes of the K-1 Strain of Streptomyces Griseus Obtained from a Commercial Preparation (Pronase). XI. Evolutionary Implications Relationships Between the Structures and Activities of Some Microbial Serine Proteases. I. Purification, Enzymic Properties, and Primary Structures of Streptomyces Griseus Proteases A, B, and Trypsin Relationship Between the Structures and Activities of Some Microbial Serine Proteases. II. Comparison of the Tertiary Structures of Microbial and Pancreatic Serine Proteases Biological Functions of Activated Complement Proteins in Normal and Disease States The Nature and Reactions of Complement Enzymes Serine Proteases of Coagulation and Their Inhibitors Homologous "Kringle" Structures Common to Plasminogen and Prothrombin. Substrate Specificity of Enzymes Activating Pro-Thrombin and Plasminogen Fibrin Formation and Dissolution Proteases Produced by Normal and Malignant Cells in Culture The Role of Lysosomes in Protein Turnover Studies of the Selectivity and Mechanisms of Intracellular Protein Degradation The Role of Neutral and Acid Proteinases in Connective Tissue Turnover Proteolytic Control of Collagen Breakdown Substrate Specificity in Pinocytosis and Intralysosomal Protein Digestion Poster Session: Communications Activation of Cuticle Chitinase: A Probable New Instance of Activation by Partial Proteolysis Effects of Added Nucleophiles on the Cathepsin B1 Catalyzed Hydrolysis of CBZ-L-Lysine p-Nitrophenyl Ester. Evidence for an Acyl Enzyme Intermediate and Leaving Group Specificity Regulation of the Leukocyte Proteinases by the Human Plasma Proteinase Inhibitors An Estimation of the Distance from the Active Site to the Calcium Binding Site in Trypsin Natural and Synthetic Peptide Inhibitors of Pepsin Further Evidence for a Proton Pump in Phagolysosomes and the Involvement of Lysosomes in Protein Turnover Intracellular Cysteine Proteases from Bovine Liver Charge Relay of Serine Proteinases: NMR Studies of Free and Inhibited Forms of Trypsin and Chymotrypsin Modification of the Properties of Trypsin by Covalent Attachment of Polysaccharide Autocatalytic Activation of Cls Vitamin ? - Dependent Synthesis and Modification of Precursor Prothrombin in Cultured Liver Cells On the Specificities of Proteases in the Healing Human Burn Wound Protein Metabolism in Fetal Rat Liver from Chronic Alcoholic Mothers Neutral and Acid Metalloproteinases in Human Articular Cartilage Which Degrade Proteoglycan Proteinases and Proteinase Inhibitors in Fertilization Characterisation of Elastase and Chymotrypsin from Human Granulocyte Lysosomes Thermodynamics of Substrate Analog Binding to Native and Modified Forms of a-Chymotrypsin; A Study in "Productive" and Non-Productive Binding Inhibition of Lethality in Endotoxin Challenged Mice Treated with Zinc Chloride Relationship Between Zinc Content and Trypsin Binding Activity of Alpha2 -Macroglobulin Measurement of Rat Protein Metabolism In Vivo