Regulation of matrix Accumulation

Regulation of Matrix Accumulation discusses the development of research and studies on connective tissue. This book emphasizes biochemical characterization of individual connective tissue components and interactions between cells and extracellular macromolecules. Other topics include the intracellular turnover of collagen; biological regulation of collagenase activity; feedback regulation of collagen synthesis; steroid hormone regulation of extracellular matrix proteins; and control of elastin synthesis, including its molecular and cellular aspects. The catalytic and biological properties of elastases; characterization and regulation of lysyl oxidase; and matrix accumulation and the development of form, considering proteoglycans and branching morphogenesis, are explained as well. Included in this text is an autobiography and personal retrospective by Miles Partridge, one of the contributors that greatly influenced the progress in understanding extracellular matrix biology. This publication is a good reference for students and researchers conducting work on biology, specifically on connective tissue.

Table of Contents:
Contributors Preface Reflections on a Career in Connective Tissue Research Text References Intracellular Turnover of Collagen Introduction II. Biosynthesis III. Proteolytic Processing of Secretory Proteins IV. Role of Intracellular Proteinases in Maintaining Collagen Synthesis V. Degradation of Secretory Proteins: Collagen VI. Regulation of Collagen Production by Changes in Intracellular Degradation References The Biological Regulation of Collagenase Activity I Introduction II. Regulatory Aspects of Molecules Intrinsic to the Collagenolytic System III. Extrinsic Regulation of Collagenase Activity: A Selective Survey of Collagenolytic Systems and Their Regulation IV. Summary and Future Perspective References Feedback Regulation of Collagen Synthesis I. Introduction II. The Aminopropeptides III. Experiments on Feedback Inhibition of Aminopropeptides on Collagen Biosynthesis IV. Clinical Importance of Collagen Feedback Regulation References Steroid Hormone Regulation of Extracellular Matrix Proteins Introduction II. Glucocorticoid Regulation of Collagen Metabolism in Tissues III. Glucocorticoid Regulation of Collagen Metabolism in Cells IV. Sex Hormone Regulation of Collagen Metabolism in Tissues V. Sex Hormone Regulation of Collagen Metabolism in Cells VI. Glucocorticoid Regulation of Elastin Metabolism in Tissues VII. Glucocorticoid Regulation of Elastin Metabolism in Cells VIII. Sex Hormone Regulation of Elastin Metabolism in Vascular Tissue IX. Steroid Hormone Regulation of Fibronectin Metabolism in Liver and Cells X. Future Prospectives of Steroid Hormone Regulation of the Synthesis of the Proteinaceous Components of the Extracellular Matrix References Control of Elastin Synthesis: Molecular and Cellular Aspects I. Introduction II. Molecular Biology III. Biosynthesis and Secretion IV. Assembly of Elastic Fibers V. Regulation of Production VI. Evolution of Elastin VII. Summary and Perspectives References Elastases: Catalytic and Biological Properties I. Introduction II. Definition and Occurrence III. Pancreatic Elastases: Occurrence and Molecular Properties IV. Leukocyte Elastases: Occurrence and Molecular Properties V. Catalytic Properties of Pancreatic and Leukocyte Elastases VI. Pancreatic and Leukocyte Elastase Inhibitors VII. Other Mammalian Elastases VIII. Nonmammalian Elastases IX. Assay of Elastases: A Critical Minireview X. Pathological Role of Elastases XI. Elastase Inhibitors as Potential Drugs XII. Concluding Remarks References Characterization and Regulation of Lysyl Oxidase I. Introduction II. Posttranslational Modifications of Connective Tissue Proteins III. Assay and Purification of Lysyl Oxidase IV. Physical Properties V. Catalytic Properties VI. Pathology VII. Physiological Control of Lysyl Oxidase VIII. Summary and Prospects References Matrix Accumulation and the Development of Form: Proteoglycans and Branching Morphogenesis Introduction II. Branching Morphogenesis III. Proteoglycans and Hyaluronic Acid IV. Proteoglycans and Hyaluronate in Branching Organs V. Effects of ß-D-Xyloside VI. Basal Lamina in Branching Morphogenesis VII. Possible Functions of Proteoglycans in Branching Morphogenesis References Index