Practical Biostatistics
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Practical Biostatistics: A Friendly Step-by-Step Approach for Evidence-based Medicine

Practical Biostatistics: A Friendly Step-by-Step Approach for Evidence-based Medicine


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About the Book

Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision making. It is a practice that uses statistical analysis of scientific methods and outcomes to drive further experimentation and diagnosis. The profusion of evidence-based medicine in medical practice and clinical research has produced a need for life scientists and clinical researchers to assimilate biostatistics into their work to meet efficacy and practical standards. Practical Biostatistics provides researchers, medical professionals, and students with a friendly, practical guide to biostatistics. With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or a hands-on guide to effectively incorporate biostatistics in clinical trials.

Table of Contents:
PART 1 - STUDY TYPE DETERMINATION1. Epidemiological studies 2. Analytical studies 3. Summary PART 2 - OBSERVATIONAL STUDIES 4. Determination of association strength between an exposure factor and an event in observational studies5. Increasing accuracy in observational studies PART 3 - STEP-BY-STEP BIOSTATISTICS OF A CLINICAL TRIAL6. STEP 1: Investigator's hypothesis and expression of its corresponding outcome7. STEP 2: n estimation and n assessment of a published trial8. STEP 3: Organization of variables and endpoints9. STEP 4: Measures for results expression of a clinical trial10. STEP 5: Determination of normality or non-normality of data distribution 11. STEP 6: Hypothesis testing12. STEP 7: Correlating sample data with the general population - 95% confidence Interval PART 4 - ADDITIONAL CONCEPTS IN BIOSTATISTICS13. Individual and collective benefit and risk indexes inferable from intervention cohort studies14. Statistical assessment of diagnostic tests for the clinic15. Systematic reviews and meta-analyses16. Correlation and regression17. Per protocol analysis and intention to treat analysis

About the Author :
* Board Certification in Internal Medicine and Hematology-Hemotherapy * Post-graduation in Pharmaceutical Medicine (Universidade Federal do Estado de Sao Paulo) * Clinical Research Dpt. (Gross Pharmaceuticals) * Member of the American College of Physicians * Professor of Clinical Immunology - Carlos Chagas Institute of Medical Post-graduation (Rio de Janeiro) - Brazil * Professor of Microbiology and Immunology at Teresopolis University Medical School (Rio de Janeiro State) * Research Fellow - Fundacao Educacional Serra dos Orgaos (Rio de Janeiro) * Professor & Chairman of Immunology & Microbiology - Teresopolis Medical School (Centro Universitario Serra dos Orgaos - UNIFESO. Rio de Janeiro, Brazil) * Professor & Coordinator of the Genodermatoses Sector of the Clinical Genetics Service (Instituto de Puericultura e Pediatria Martagao Gesteira - UFRJ. Rio de Janeiro, Brazil) * Professor and Chairman of Clinical Immunology (Instituto de Pos-Graduacao Medica Carlos Chagas. Rio de Janeiro, Brazil) * Member of the clinical staff of Hospital Israelita Albert Einstein (HIAE - Sao Paulo, Brasil) Mauro Geller MD, PhD holds an MD degree from Teresopolis University Medical School, a PhD in Clinical Medicine from Universidade Federal do Rio de Janeiro, and a Post-PhD in Immunogentics from Harvard University. He has extensive experience in the area of clinical immunology, especially in the areas of clinical medicine, tumoral immunology, genetics and immunodiagnostics. Dr. Geller is a founding member of the Brazilian National Neurofibromatosis Center (Centro Nacional de Neurofibromatose - CNNF), where he also serves as Scientific Director. He is a two-time recipient of the Mocao de Louvor of the Assembleia Legislativa do Estado do Rio de Janeiro; in 1994 he received the Titulo de Benmerito do Estado do Rio de Janeiro, and he has received several awards of recognition from UNIFESO, from both the faculty and students. In 1996, he was awarded the Public Service Award from the National Neurofibromatosis Foundation and in 1997 he was named Honorary Chairperson of the same institution. IN 2006, he received the Premio de Incentivo Cientifico Hilton souchois from the Brazilian Society of Odontology. He also has extensive experience with research in the areas of immunology, microbiology and genetics, as well as with clinical research, and has published 137 papers, 8 book chapters, and 4 books. He also serves as an ad hoc advisor to the Brazilian National Institute of Health (ANVISA).

Review :
"With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or a hands-on guide to effectively incorporate biostatistics in clinical trials."--Doody.com, April 24, 2013 "Practical Biostatistics is destined to be a companion book for health professionals and graduation students who face the challenge of assimilating concepts on statistics." Mauri Carakushansky, MD Pediatric Endocrinologist - Nemours Children's Clinic Orlando, Assistant Professor of Pediatrics - Florida State University, Assistant Professor of Pediatrics - University of Central Florida "This work by Dr. Suchmacher and Dr. Geller is bound to become a classic and should be readily available on the desk, shelf and on line." Salin Dahlben, Harvard University, Clinical Assistant Professor in Psychiatry, Tufts University "Dr. Suchmacher and Dr. Geller are experienced researchers and writers in the clinical research field, who were able to fathom the often confusing realm of Statistics applied to biological sciences, and to come back with a pragmatic study proposal for interested medical students and healthcare professionals [.] In my opinion, 'Practical Biostatistics' will undoubtedly be welcomed as one of the books designed to bring medical students and healthcare professionals alike, closer to a better understanding of this inescapable issue." Spyros G.E. Mezitis, Assistant Professor of Clinical Medicine, The New York Presbyterian Hospital Weill, Cornell Medical Center "I believe the result of [Drs. Suchmacher and Geller's] efforts will prove useful for many medical students and researchers, who must thrive in an era when Biostatistics is destined to be an ever present matter." Allan E. Rubenstein, Clinical Professor of Neurology, The Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, Langone Medical Center, School of Medicine, New York University Practical Biostatistics is destined to be a companion book for health professionals and graduation students who face the challenge of assimilating concepts on statistics." Mauri Carakushansky, MD, Pediatric Endocrinologist - Nemours Children's Clinic Orlando, Assistant Professor of Pediatrics - Florida State University, Assistant Professor of Pediatrics - University of Central Florida


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Product Details
  • ISBN-13: 9780124157941
  • Publisher: Elsevier Science Publishing Co Inc
  • Publisher Imprint: Academic Press Inc
  • Height: 229 mm
  • No of Pages: 248
  • Weight: 340 gr
  • ISBN-10: 0124157947
  • Publisher Date: 14 Sep 2012
  • Binding: Paperback
  • Language: English
  • Sub Title: A Friendly Step-by-Step Approach for Evidence-based Medicine
  • Width: 152 mm


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