Essential Concepts in Molecular Pathology

This streamlined "essential" version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.

Table of Contents:
PART I Essential Pathology - Mechanisms of Disease 1 Cell Injury, Cell Death, and Cellular Adaptation John J. Lemasters, M.D., Ph.D. 2 Acute and Chronic Inflammation Vladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D. 3 Infection and Host Response Sheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D. 4 Neoplasia William B. Coleman, Ph.D., and Tara Rubinas, M.D. PART II Concepts in Molecular Biology and Genetics 5 Basic Concepts in Human Molecular Genetics W. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C. 6 The Human Genome: Implications for the Understanding of Human Disease William B. Coleman, Ph.D, Gregory J. Tsongalis, Ph.D. and Ashley Rivenbark, M.D. 7 The Human Transcriptome: Implications for the Understanding of Human Disease Reinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D. 8 The Human Epigenome: Implications for the Understanding of Human Disease Manel Esteller, Ph.D. and Maria Berdasco, Ph.D. 9 The Human Proteome: Implications for the Understanding of Human Disease Lance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin 10 Integrative Systems Biology: Implications for the Understanding of Human Disease M. Michael Barmada, Ph.D. and David C. Whitcomb PART III Principles and Practice of Molecular Pathology 11 Pathology: The Clinical Description of Human Disease William K. Funkhouser, M.D., Ph.D. 12 Molecular Pathogenesis: The Biological Basis of Human Disease William B. Coleman, Ph.D, and Gregory J. Tsongalis, Ph.D. 13 Integration of Molecular and Cellular Pathogenesis Jason H. Moore, Ph.D., and C. Harker Rhodes, M.D. PART IV Molecular Pathology of Human Disease 14 Molecular Basis of Cardiovascular Disease Avrum I. Gotlieb, M.D.C.M. and Amber Chang Liu 15 Molecular Basis of Hemostatic and Thrombotic Diseases Nigel S. Key, M.D., and Alice Ma, M.D. 16 Molecular Basis of Lymphoid and Myeloid Diseases Dong-Er Zhang, Ph.D. and Joseph Biggs, Ph.D. 17 Molecular Basis of Diseases of Immunity David O. Beenhouwer, Ph.D. 18 Molecular Basis of Pulmonary Disease Dani S. Zander, M.D., and Carol Farver, M.D. 19 Molecular Basis of Diseases of the Gastrointestinal Tract Antonio Sepulveda, M.D., Ph.D. and Dara L. Aisner, M.D., Ph.D. 20 Molecular Basis of Liver Disease Satdarshan P. Singh Monga, M.D. and Jaideep Behari, M.D. 21 Molecular Basis of Diseases of the Exocrine Pancreas Markus M. Lerch, M.D. 22 Molecular Basis of Diseases of the Endocrine System Malcolm M. Martin, M.D., Arlene L. Martin, M.D., Alan L.Y. Pang, Ph.D., and Wai-Yee Chan, Ph.D. 23 Molecular Basis of Gynecologic Diseases Samuel Chi-ho Mok, Ph.D., Kwong-Kwok Wong, Ph.D., Karen Lu, M.D., Karl Munger, Ph.D., and Zoltan Nagymanyoki, Ph.D. 24 Molecular Pathogenesis of Diseases of the Kidney Amy K. Mottl, M.D., M.P.H., and Carla Nester, M.D., M.S.A. 25 Molecular Basis of Prostate Disease William G. Nelson, M.D., Ph.D., Angelo M. De Marzo, M.D., Ph.D., and Carlise R. Bethel, M.D., Ph.D. 26 Molecular Basis of Breast Disease Christos Sotiriou, M.D., Ph.D., Natasha Snoj, Phuong Dinh, and Philippe Bedard Translational Research Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, Belgium 27 Molecular Basis of Skin Disease John A. McGrath, Ph.D., and Vesarat Wessagowit, M.D., Ph.D. 28 Molecular Basis of Diseases of the Nervous System Joshua A. Sonnen, M.D., C. Dirk Keene, M.D., Robert F. Hevner, M.D., and Thomas J. Montine, M.D., Ph.D.   PART V Practice of Molecular Medicine 29 Molecular Diagnosis of Human Disease Grant Bullock, M.D., Ph.D., and Lawrence M. Silverman, Ph.D. 30 Molecular Assessment of Human Disease in the Clinical Laboratory Gregory J. Tsongalis, Ph.D. and Joel A. Lefferts, M.D. 31 Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease Gregory J. Tsongalis, Ph.D. and Hong Kee Lee, Ph.D.

About the Author :
William B. Coleman, PhD is Professor of Pathology and Laboratory Medicine and Director of Graduate Studies for the Molecular and Cellular Pathology Graduate Program at the University of North Carolina School of Medicine (Chapel Hill, NC). Dr. Coleman is co-director of the UNC Program in Translational Medicine, and co-director of the Environmental Pathology Predoctoral and Postdoctoral Training Program. In addition, he is affiliated with the Curriculum in Toxicology and is a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is actively involved in teaching biomedical graduate students and is a three-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at UNC-Chapel Hill. Dr. Coleman is active in the leadership of the American Society for Investigative Pathology, and is a member of the American Association for Cancer Research. He serves on the editorial boards of Clinica Chimica Acta, The American Journal of Pathology, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, and Laboratory Investigation, and has served as an ad hoc reviewer for 48 other journals. Dr. Coleman's major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research has been funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 100 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored six books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer. Gregory J. Tsongalis, Ph.D., H.C.L.D., C.C. is Professor of Pathology, Director, Molecular Pathology, and Co-Director Translational Research Program, Department of Pathology, Dartmouth Hitchcock Medical Center and The Audrey and Theodor Geisel School of Medicine at Dartmouth, Lebanon, NH, USA

Review :
"Essential Concepts in Molecular Pathology provides the reader with what is missing from most targeted introductions to pathology; the cell biology behind pathophysiology. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ; the text provides the student with the background necessary for the understanding of today’s advances in pathology and medicine. The book is compact, easy to follow, filled with useful tables and figures and deserves reading by students and professionals interested in the molecular basis of disease."--Howard Reisner PhD, Professor of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, North Carolina, USA "Finally, a book that captures the real world environment of molecular diagnosis and pathology of a comprehensive range of diseases while establishing a foundation in the basics of molecular biology is available in Essential Concepts in Molecular Pathology! The clinical hospital laboratory has become a critical link in the rapidly changing way in which we diagnose disease with respect to molecular diagnostics. It has been challenging to embed the fundamentals of molecular diagnosis to students of clinical laboratory science (CLS) programs without a resource of the most current, state-of-the-art molecular foundations. Essential Concepts has not only offered an outstanding textbook to build future CLS practitioners, but it also represents an outstanding "working" resource for the established molecular pathologist and others involved biomedical research.  As the title states, the individual chapters relate the most important points about specific topics with excellent figures and examples while directing the user to Suggested Readings for more in-depth coverage. The editors have put together a wonderful resource for allied health programs and similar professionals to use as a textbook or as a companion to a more comprehensive molecular pathology offering."--Rodney E. Rohde, MS, SV, SM, MP (ASCP), Associate Professor, Texas State University-San Marcos, Clinical Laboratory Science, San Marcos, TX, USA