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Home > Mathematics and Science Textbooks > Biology, life sciences > Biochemistry > Nitric Oxide: Biology and Pathobiology
Nitric Oxide: Biology and Pathobiology

Nitric Oxide: Biology and Pathobiology


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About the Book

Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications.

Table of Contents:
Contributors Preface Section I Overview of Basic Principles Chapter 1 Introduction and Overview Section II Principles of Biology A. Chemical Biology Chapter 2 The Chemical Properties of Nitric Oxide and Related Nitrogen Oxides Chapter 3 The Chemical Biology of Nitric Oxide Chapter 4 The Biological Chemistry of Peroxynitrite Chapter 5 A Comparison of the Biological Reactivity of Nitric Oxide and Peroxynitrite B. Nitric Oxide Synthases Chapter 6 Structural Variations to Accommodate Functional Themes of the Isoforms of NO Synthases Chapter 7 Regulation of the Expression of Nitric Oxide Synthase Isoforms Chapter 8 Molecular Regulation of Inducible Nitric Oxide Synthase Chapter 9 Molecular Control of Endothelial Derived Nitric Oxide: A New Paradigm for Endothelial NOS Regulation by Posttranslational Modification C. Regulation of Nitric Oxide Production Chapter 10 Tetrahydrobiopterin: An Essential Cofactor of Nitric Oxide Synthase with an Elusive Role Chapter 11 Regulation of Arginine Availability and Its Impact on NO Synthesis Chapter 12 Relationship between Arginase Activity and Nitric Oxide Production D. Transport, Membrane Interactions, and Oxygen Transport Chapter 13 The Physical Properties of Nitric Oxide: Determinants of the Dynamics of NO in Tissue Chapter 14 Membrane Transport of Arginine and Cationic Amino Acid Analogs Chapter 15 The Respiratory Cycle: A Three-Gas System E. Nitric Oxide and Oxidative Stress Chapter 16 Role for Nitric Oxide and Other Radicals in Signal Transduction Chapter 17 Antioxidant Actions of Nitric Oxide Chapter 18 Mechanisms through Which Reactive Nitrogen and Oxygen Species Interact with Physiological Signaling Systems Chapter 19 Nitric Oxide, Oxygen Radicals, and Iron Metabolism Chapter 20 Redox Modulation of Iron Regulatory Proteins by Nitric Oxide and Peroxynitrite Chapter 21 Nitric Oxide, Oxidative Stress, and Signal Transduction Chapter 22 Mechanisms of Antioxidant Defense against Nitric Oxide/Peroxynitrite Chapter 23 Regulation of Oxygen Metabolism by Nitric Oxide F. Signal Transduction Mechanisms Chapter 24 Structure–Function Relationships in NO-Sensitive Guanylyl Cyclase Chapter 25 Mechanism of Activation of Soluble Guanylyl Cyclase by NO: Allosteric Regulation through Changes in Heme Coordination Geometry Chapter 26 Cyclic GMP-Mediated Signaling Mechanisms in Smooth Muscle Section III Principles of Pathobiology A. NO and the Nervous System Chapter 27 Influence of Nitric Oxide on Neuroendocrine Function and Behavior Chapter 28 Nitric Oxide and Cerebral Ischemia Chapter 29 Role of Nitric Oxide in Neuronal Protection versus Apoptosis Chapter 30 Nitric Oxide and Autoimmune Disease in the Nervous System: Pathobiology of Inflammation and Demyelination B. NO and Cardiovascular Function Chapter 31 Role of Nitric Oxide in the Regulation of Blood Flow Chapter 32 Nitric Oxide Synthase Gene Transfer Chapter 33 Functional Influence of Gene Transfer of Recombinant Nitric Oxide Synthase to Cardiovascular System Chapter 34 Nitric Oxide and Vascular Endothelial Dysfunction Chapter 35 Endothelium-Derived Hyperpolarizing Factor and Its Interaction with NO Chapter 36 Role of Nitric Oxide in Myocardial Function Chapter 37 Role of Nitric Oxide in the Microcirculation Chapter 38 Activation of NOS by Ca2+-Dependent and Ca2+-Independent Mechanisms C. Pathophysiological Mechanisms of Nitric Oxide Chapter 39 Role of Nitric Oxide in Ischemia–Reperfusion Injury Chapter 40 Nitric Oxide: A Critical Determinant in Ischemia–Reperfusion Chapter 41 Role of Nitric Oxide in Myocardial Ischemia–Reperfusion Injury Chapter 42 Use of Mutant Mice to Elucidate Neuroprotective and Neurotoxic Actions of Nitric Oxide in Cerebral Ischemia Chapter 43 Neurotoxic Actions and Mechanisms of Nitric Oxide Chapter 44 Role of Macrophage-Derived Nitric Oxide in Target Cell Injury Chapter 45 Physiological and Pathophysiological Roles of Nitric Oxide in Gastrointestinal Function Chapter 46 Pathophysiological Effects of High-Output Production of Nitric Oxide Chapter 47 Nitric Oxide and Septic Shock Chapter 48 Nitric Oxide and Vascular Disease Chapter 49 Cytotoxic Role of Nitric Oxide in Diabetes Chapter 50 Role of Inducible Nitric Oxide Synthase in Autoimmune or Other Immune-Mediated Diseases Chapter 51 Nitric Oxide and Platelet Function Chapter 52 Pathophysiological Roles of Nitric Oxide in Inflammation Chapter 53 Nitric Oxide, Chronic Joint Inflammation, and Pain Chapter 54 Nitric Oxide and Cancer D. Clinical Significance of Nitric Oxide Chapter 55 Vascular Nitric Oxide in Health and Disease Chapter 56 Clinical Therapy with Inhaled Nitric Oxide in Respiratory Diseases Chapter 57 Airborne Nitric Oxide in Health and Disease Chapter 58 Nitric Oxide and Persistent Pulmonary Hypertension in the Newborn Index

About the Author :
Louis J. Ignarro, PhD, is Distinguished Professor Emeritus of the Department of Molecular and Medical Pharmacology at the UCLA School of Medicine. He has broad and extensive experience in the molecular and chemical biology of the nitric oxide-cyclic GMP signaling systems. He and his basic research teams have discovered and expanded the production and actions of nitric oxide in mammalian tissues, including the protective roles of nitric oxide in preventing hypertension, stroke and myocardial infarction, and its neurotransmitter role as the mediator of erectile function in humans. For these discoveries, he was awarded the Nobel Prize in Physiology or Medicine.

Review :
"... for those researchers interested in the detailed biochemistry of nitric oxide and its synthesis, the book will be a very valuable reference" --TODAY'S LIFE SCIENCE "Louis J. Ignarro, pharmacologist in Los Angeles, participated in the quest for EDRF's chemical nature. He performed a brilliant series of analyses and concluded in 1986, together with and independently of Robert Furchgott, that EDRF was identical to NO. The problem was solved and Furchgott's endothelial factor identified. When Furchgott and Ignarro presented their conclusions at a conference in July 1986, it elicited an avalanche of research activities in many different laboratories around the world. This was the first discovery that a gas can act as a signal molecule in an organism." --THE NOBEL ASSEMBLY, KAROLINSKA INSTITUTE, 1998


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Product Details
  • ISBN-13: 9780123704207
  • Publisher: Elsevier Science Publishing Co Inc
  • Publisher Imprint: Academic Press Inc
  • Height: 279 mm
  • No of Pages: 1017
  • Weight: 2670 gr
  • ISBN-10: 0123704200
  • Publisher Date: 13 Sep 2000
  • Binding: Hardback
  • Language: English
  • Sub Title: Biology and Pathobiology
  • Width: 216 mm


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